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Cat No. | Product Name | Synonyms | Targets |
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T9696 | β-catenin-IN-2 | Wnt/beta-catenin | |
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research. | |||
T67884 | β-catenin modulator IIa-661 | Wnt/beta-catenin | |
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity. | |||
T9988 | Wnt/β-catenin agonist 3 | Wnt/beta-catenin | |
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist. | |||
TP1730L | β-catenin peptide acetate(265669-37-2 free base) | Others | |
β-catenin peptide(βCATp) acetate is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes. | |||
T41094 | Wnt/β-catenin agonist 2 | GSK-3 , Wnt/beta-catenin | |
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva... | |||
T39200 | β-catenin-IN-37 | ||
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of... | |||
T60803 | Wnt/β-catenin agonist 4 | Wnt/beta-catenin | |
Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling. | |||
T6868 | KYA1797K | Wnt/beta-catenin | |
KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay. | |||
TP1730 | β-catenin peptide | ||
β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes. | |||
T6989 | SKL2001 | Wnt/beta-catenin | |
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction. | |||
T15137 | DK419 | Wnt/beta-catenin , AMPK | |
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK. | |||
T8400 | Pamidronic acid | Wnt/beta-catenin | |
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells | |||
T6113 | ICG-001 | Apoptosis , Epigenetic Reader Domain , Wnt/beta-catenin | |
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. | |||
T8710 | MSAB | Wnt/beta-catenin | |
MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. | |||
T12537 | β-catenin/CBP-IN-1 | Wnt/beta-catenin | |
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin | |||
T21685 | CCT 031374 hydrobromide | Wnt/beta-catenin | |
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities. | |||
T2413 | FH535 | Wnt/beta-catenin , PPAR | |
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities. | |||
T13344 | Wnt/β-catenin agonist 1 | Others | |
Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM). | |||
T9182 | NRX-252262 | Others , Wnt/beta-catenin | |
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM) | |||
T1971 | WAY-262611 | Wnt/beta-catenin | |
WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay. | |||
T15677 | KY1220 | Wnt/beta-catenin | |
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells. | |||
T7399 | LF3 | Wnt/beta-catenin | |
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM) | |||
T9151 | Teplinovivint | Wnt/beta-catenin | |
Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. It has anti-inflammatory activity and has the potential for tendinopathy research. | |||
T7204 | PNU-74654 | Apoptosis , Wnt/beta-catenin | |
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. | |||
T5642 | Tegatrabetan | BC2059 | Wnt/beta-catenin |
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity. | |||
T2161 | Cardiogenol C | Wnt/beta-catenin | |
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells. | |||
T3062 | WIKI4 | PARP , Wnt/beta-catenin | |
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). | |||
T10904 | CWP232228 | Wnt/beta-catenin | |
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t... | |||
T3635 | IQ 1 | IQ1,IQ-1 | Wnt/beta-catenin |
IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on. | |||
T17142 | Toxoflavin | Xanthothricin,PKF-118-310,Toxoflavine | Wnt/beta-catenin , Antibacterial , Antibiotic |
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A. | |||
T0470 | Nefopam hydrochloride | Fenazoxine hydrochloride,Nefopam HCl | Wnt/beta-catenin , Sodium Channel |
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity. | |||
T1878 | XAV-939 | XAV939,NVP-XAV939 | PARP , Wnt/beta-catenin |
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription. | |||
T22884 | JW 67 | Wnt/beta-catenin | |
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. | |||
T72829 | β-catenin-IN-4 | ||
β-catenin-IN-4 is a β-catenin inhibitor with a K i of 0.64 μM. β-catenin-IN-4 reduces the protein expression levels of cyclin D1 and c-Myc . | |||
T78919 | β-catenin-IN-7 | ||
β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, and exhibits anticancer activity [1]. | |||
T79102 | β-Catenin modulator-3 | ||
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole-based chemical entity, serves as a potent and selective modulator of β-Catenin [1]. | |||
T16079 | Mirodenafil | SK3530 | PDE |
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. | |||
T2310 | CHIR-99021 | Laduviglusib,CT99021,CHIR-99021 | GSK-3 , Wnt/beta-catenin , Autophagy |
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in... | |||
T8005 | Cardiogenol C hydrochloride | Cardiogenol C HCl,Cardiogenol C | Wnt/beta-catenin |
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). | |||
T79100 | β-Catenin modulator-1 | ||
β-Catenin modulator-1 (IIa-650) is a useful agent in cancer research for modulating β-Catenin [1]. | |||
T79101 | β-Catenin modulator-2 | ||
β-Catenin Modulator-2 (Compound IIa-130), which is an oxazole-thiazole derivative, serves as a potent and selective modulator of β-Catenin [1]. | |||
T79104 | β-Catenin modulator-5 | ||
β-Catenin Modulator-5 (Compound IIa-84), an oxazole and thiazole-based compound, serves as a potent and selective modulator of β-Catenin [1]. | |||
T63212 | β-catenin-IN-3 | ||
β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces the viability of β-catenin-driven cancer cells. | |||
T78120 | β-catenin-IN-6 | ||
β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2]. | |||
T79103 | β-Catenin modulator-4 | ||
β-Catenin modulator-4 (compound IIa-92), encompassing oxazole and thiazole moieties, acts as a potent and selective modulator of β-Catenin [1]. | |||
T11571 | HLY78 | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine | Wnt/beta-catenin |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. | |||
T11284 | FIDAS-3 | Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT) | |
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S... | |||
T39341 | FCPR03 | PDE | |
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr... | |||
T82235 | HCA/Wnt/β-catenin-IN-1 | ||
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-g... | |||
TQ0126 | Mirodenafil dihydrochloride | SK-3530 dihydrochloride | PDE |
Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5729 | L-quebrachitol | Wnt/beta-catenin | |
L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway. | |||
T3925 | Astragaloside I | Cyclosieversioside B,Astrasieversianin IV | Wnt/beta-catenin |
Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus. | |||
TN1079 | Deoxyelephantopin | NF-κB | |
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling | |||
T5679 | (E)-Ferulic acid | trans-Ferulic acid,(E)-Coniferic acid | BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite |
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr... | |||
T5S1058 | Triptonide | PG 492,NSC 165677 | Apoptosis , Wnt/beta-catenin , Autophagy |
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, an... | |||
TN1413 | Atranorin | Endogenous Metabolite , NO Synthase , Ras | |
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv... | |||
TN7036 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 | Wnt/beta-catenin |
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa... | |||
TQ0215 | Salinomycin sodium salt | Sodium salinomycin,Salinomycin sodium | Apoptosis , Wnt/beta-catenin , Antibacterial , Antibiotic , Autophagy |
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling. | |||
TN6508 | Trachelogenin | (-)-Trachelogenin | Virus Protease , c-Myc , HCV Protease , Wnt/beta-catenin |
Trachelogenin ((-)-Trachelogenin), an HCV entry inhibitor, has antiproliferative effects, and its mechanism is related to affecting the phosphorylation of key proteins in the β-Catenin signaling pathway, such as β-Cateni... | |||
T3330 | Trans-Trimethoxyresveratrol | trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene | Reactive Oxygen Species |
trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy... | |||
TL0008 | Gigantol | Wnt/beta-catenin , Glucosidase | |
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a... | |||
T0906 | Salinomycin | Procoxacin | Wnt/beta-catenin , Antibacterial |
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph... | |||
T8229 | 5,7,3',4'-Tetramethoxyflavone | Antibacterial , Parasite , Antifungal | |
5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflamm... | |||
T4S1796 | Heterophyllin B | PI3K | |
Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa... | |||
T2818 | Methyl Vanillate | Reactive Oxygen Species , Wnt/beta-catenin , Endogenous Metabolite | |
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methyl vanillate is considered to be a slightl... | |||
TL0007 | Bisdemethoxycurcumin | Curcumin III,Didemethoxycurcumin | Epigenetic Reader Domain , Wnt/beta-catenin |
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac... | |||
T3391 | Corosolic acid | Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid | FAK , Autophagy |
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci... | |||
TN1103 | Diphyllin | ATPase , Proton pump , Influenza Virus , HIV Protease | |
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. | |||
T4S1943 | Kirenol | Kirel | Wnt/beta-catenin |
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid... | |||
T5S1982 | Periplocin | Periplocoside | Apoptosis , Others |
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. 2. Periplocin is used for treatment of rheumato... | |||
T5S0896 | Loureirin A | Akt , PI3K | |
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced platelet aggregation such as collagen, collagen-related pept... | |||
T2771 | Orcinol glucoside | Sakakin | Antioxidant |
Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects. | |||
T3803 | Specnuezhenide | Nuzhenide,Nuezhenide | Others , NF-κB , Wnt/beta-catenin |
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t... | |||
T3S0153 | Xanthatin | Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial | |
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr... | |||
T1716 | Echinacoside | Reactive Oxygen Species , Wnt/beta-catenin | |
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilat... | |||
T5S0754 | Isoquercetin | 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside | NF-κB , Wnt/beta-catenin , NO Synthase |
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ... | |||
T23645 | Aeroplysinin 1 | NSC170364,Aeroplysinin I,NSC 170364,NSC-170364 | |
Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation. | |||
TN2371 | Isoliquiritin | Neoisoliquiritin | Others |
Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway | |||
T40643 | Prodigiosin hydrochloride | Prodigiosine hydrochloride | |
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this ... | |||
T1033L | Monensin | Elancoban,Rumensin | |
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with d... | |||
TN3468 | Atractylochromene | Wnt/beta-catenin | |
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. | |||
T75621 | Secalonic acid D | ||
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus . Secalonic acid D activates GSK3-β , and degrades β-catenin . Thus, Secalonic acid... | |||
TN2775 | 2-Methoxystypandrone | MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT | |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02205 | Beta-Catenin Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p... | |||
TMPY-02985 | Beta-Catenin Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p... | |||
TMPY-01121 | DKK3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 p... | |||
TMPY-06418 | R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene... | |||
TMPY-03626 | R-Spondin 1/RSPO1 Protein, Human, Recombinant | Human | CHO |
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r... | |||
TMPY-01147 | R-Spondin 1/RSPO1 Protein, Human, Recombinant (His) | Human | HEK293 |
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r... | |||
TMPY-04153 | RNF43 Protein, Human, Recombinant (His) | Human | HEK293 |
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr... | |||
TMPY-03722 | EpCAM/TROP1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d... | |||
TMPY-02030 | CD82 Protein, Human, Recombinant (His) | Human | HEK293 |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras... | |||
TMPY-01300 | EpCAM/TROP1 Protein, Human, Recombinant (His) | Human | HEK293 |
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d... | |||
TMPY-02115 | R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His) | Human | HEK293 |
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in devel... | |||
TMPY-05587 | EpCAM/TROP1 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane d... | |||
TMPY-02118 | IGFBP-6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-bind... | |||
TMPY-04356 | GSK3B Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ... | |||
TMPJ-01332 | Frizzled-8 Protein, Human, Recombinant (His) | Human | Human Cells |
Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-coupled. Wnt engagement, with low density lipoprotein recep... | |||
TMPH-02193 | Tetraspanin-7/TSPAN7 Protein, Human, Recombinant (His) | Human | Yeast |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. | |||
TMPJ-01331 | Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | Human Cells |
Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-coupled. Wnt engagement, with low density lipoprotein recep... | |||
TMPH-03059 | Newcastle disease virus (NDV) (strain Her/33) Hemagglutinin-neuraminidase Protein (His) | NDV | E. coli |
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. | |||
TMPK-00156 | DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPK-00158 | DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPY-00223 | R-Spondin 2/RSPO2 Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 |
R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene... | |||
TMPK-01001 | RNF43 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i... | |||
TMPH-03756 | Wint7b Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d... | |||
TMPH-01603 | Lanosterol synthase/LSS Protein, Human, Recombinant (His) | Human | E. coli |
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activa... | |||
TMPY-06377 | DKK3 Protein, Human, Recombinant | Human | HEK293 |
DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 p... | |||
TMPY-03046 | APCDD1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, res... | |||
TMPY-04143 | Chemerin/RARRES2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Ret... | |||
TMPK-00744 | LRP-6 Protein, Human, Recombinant (mFc) | Human | HEK293 |
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ... | |||
TMPY-01456 | BAMBI Protein, Human, Recombinant (His) | Human | HEK293 |
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellu... | |||
TMPY-04334 | BAMBI Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellu... | |||
TMPK-00155 | DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi) | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPK-00157 | DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 |
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. | |||
TMPY-04149 | RNF43 Protein, Human, Recombinant (hFc) | Human | HEK293 |
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expr... | |||
TMPY-01798 | Frizzled 10 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Frizzled-1, also known as Fz-1, CD35 and FZD1, is a multi-pass membrane protein which belongs to theG-protein coupled receptor Fz/Smo family. Frizzled-1 / FZD1 is abundantly expressed in the cerebellum, followed by ce... | |||
TMPY-04140 | Frizzled 10 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Frizzled-1, also known as Fz-1, CD35 and FZD1, is a multi-pass membrane protein which belongs to theG-protein coupled receptor Fz/Smo family. Frizzled-1 / FZD1 is abundantly expressed in the cerebellum, followed by ce... | |||
TMPY-02094 | R-Spondin 1/RSPO1 Protein, Human, Recombinant (aa 1-146, His) | Human | HEK293 |
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r... | |||
TMPY-03197 | R-Spondin 1/RSPO1 Protein, Mouse, Recombinant (His) | Mouse | CHO |
RSPO1 gene is a member of the R-spondin family. It encodes RSPO1 which is known as a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, RSPO1 induces the r... | |||
TMPH-02573 | WISP3/CCN6 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d... | |||
TMPH-02571 | CD9 Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in e... | |||
TMPH-02576 | TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is ... | |||
TMPY-00367 | Chemerin/RARRES2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Ret... | |||
TMPK-01106 | Kremen-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-01304 | Kremen-2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPK-01093 | Kremen-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi... | |||
TMPJ-00268 | 5T4/TPBG Protein, Human, Recombinant (Avi & His), Biotinylated | Human | Human Cells |
Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG m... | |||
TMPJ-01153 | 5T4/TPBG Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Human Cells |
Trophoblast glycoprotein, also known as TPBG and 5T4, it belongs to the LRR family of proteins. The C-terminus of LRR N-terminal cap (LRRNT) and LRR 1 are essential for the inhibition of the Wnt signaling pathway. TPBG m... | |||
TMPY-01797 | Frizzled 10 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Frizzled-1, also known as Fz-1, CD35 and FZD1, is a multi-pass membrane protein which belongs to theG-protein coupled receptor Fz/Smo family. Frizzled-1 / FZD1 is abundantly expressed in the cerebellum, followed by ce... | |||
TMPY-03127 | BAMBI Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
BMP and activin membrane-bound inhibitor (BAMBI) is a transmembrane glycoprotein that is a pseudoreceptor of type 1 receptors. BAMBI structurally lacks intracellular serine/ threonine kinase domain but with an extracellu... | |||
TMPK-01179 | CDH19 Protein, Human, Recombinant (MBP & Flag) | Human | E. coli |
Cadherins play an important role in tissue homeostasis, as they are responsible for cell-cell adhesion during embryogenesis, tissue morphogenesis, differentiation and carcinogenesis. Cadherins are inseparably connected w... | |||
TMPK-00743 | LGR-5 Protein, Human, Recombinant (hFc) | Human | HEK293 |
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker... | |||
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Cat No. | Product Name | ||
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L7700 | Neural Regeneration Compound Library | 529 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; | |||
L7900 | Osteogenesis Compound Library | 320 compounds | |
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening; | |||
L2194 | Anti-Colorectal Cancer Compound Library | 1565 compounds | |
1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening. |