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Cat No. | Product Name | Synonyms | Targets |
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T11075 | Donitriptan | 5-HT Receptor | |
Donitriptan is a 5-HT receptor agonist with pKis of 9.4 and 9.3 for 5-HT1B and 5-HT1D, respectively. | |||
T37015 | Iprindole | 5-HT Receptor | |
Iprindole, a tricyclic indole antidepressant, is a dual weak inhibitor of noradrenaline and 5-HT uptake [1]. | |||
T10169 | 5-HT4 antagonist 1 | 5-HT Receptor | |
5-HT4 antagonist 1 is an antagonist of 5-HT4 (pKi = 9.6). | |||
T10075 | 2-Methyl-5-HT | 2-Methyl-5-hydroxytryptamine | 5-HT Receptor |
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects. | |||
T14490 | Talipexole dihydrochloride | Domnin,B-HT 920 dihydrochloride | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor |
Talipexole dihydrochloride (Domnin) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist, and 5-HT3 receptor antagonist in both rat cortical and intestinal membrane fractions with Ki values of 0.35 μM and 0.22 μM, ... | |||
T8666 | Naratriptan | 5-HT Receptor | |
Naratriptan is a selective agonist of 5-HT1 receptor and is is used for the treatment of migraine headaches. | |||
T8441 | Lerisetron | 5-HT Receptor | |
Lerisetron is an antagonist of serotonin type 3 (5-HT3) receptor, with antiemetic activity. | |||
T2599 | Pirenperone | 5-HT Receptor | |
Pirenperone is a putative 5-HT2 receptor antagonist with the central antiserotonergic and antidopaminergic action. | |||
T37197 | 5-HT1A modulator 2 hydrochloride | 5-HT Receptor | |
5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT , is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding[1]. [1]. Naiman, N.,et al. 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotoni... | |||
T21629 | Loxapine | Dopamine Receptor , 5-HT Receptor | |
Loxapine is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent,used primarily in the treatment of schizophrenia. The drug is a member of the dibenzoxazepine class ... | |||
T19680 | Zotepine | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor | |
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second... | |||
T5336 | Zacopride hydrochloride | Potassium Channel , 5-HT Receptor | |
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist. | |||
T6728 | VUF 10166 | 5-HT Receptor | |
VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower. | |||
T16669 | PRX-08066 | 5-HT Receptor | |
PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4 nM) antagonist that induces selective vasodilation of pulmonary arteries. | |||
T22514 | 4F 4PP oxalate | 5-HT Receptor | |
4F 4PP oxalate is a 5-HT2A antagonist. | |||
T12489 | Pimethixene | Calmixen,Pimetixene | Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor |
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... | |||
T8946 | Indophagolin | P2X Receptor , 5-HT Receptor , Autophagy | |
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. | |||
TQ0311 | GSK163090 | Dopamine Receptor , 5-HT Receptor | |
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). | |||
T0280 | Spiperone | Spiroperidol,Spiropitan | Dopamine Receptor |
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. | |||
T21946 | BIMU 8 | 5-HT Receptor | |
BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4. | |||
T12847 | SB-616234-A | SB-616234A | 5-HT Receptor |
SB-616234A is a selective and orally bioavailable antagonist of 5-HT1B receptor, with anxiolytic and antidepressant activity. | |||
T17033 | Temanogrel | APD791 | 5-HT Receptor |
Temanogrel (APD791) is a highly selective antagonist of the 5-HT2A receptor (Ki: 4.9 nM). | |||
T8357 | SB-200646 | 5-HT Receptor | |
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor | |||
T5387 | LP-211 | Dopamine Receptor , 5-HT Receptor | |
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor. | |||
T4305 | 8-OH-Dpat | 8-Hydroxy-DPAT | 5-HT Receptor |
8-OH-Dpat (8-Hydroxy-DPAT) is a serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin. | |||
T1092 | Zolmitriptan | 311C90,BW-311C90 | 5-HT Receptor |
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and... | |||
T22987 | MK 212 hydrochloride | 5-HT Receptor | |
MK 212 hydrochloride is a 5-HT2C receptor agonist | |||
T9272 | Xaliproden hydrochloride | Dopamine Receptor , 5-HT Receptor | |
Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist. | |||
T2428 | TG6-10-1 | 5-HT Receptor , Prostaglandin Receptor | |
TG6-10-1 is an EP2 antagonist. | |||
T11720 | JNJ-18038683 | 5-HT Receptor | |
JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. | |||
T12855 | SB 258719 | 5-HT Receptor | |
SB 258719 is a selective antagonist of 5-HT7 receptor(pKi of 7.5). | |||
T0165 | Urapidil | Mediatensyl,Ebrantil,Eupressyl | 5-HT Receptor , Adrenergic Receptor |
Urapidil (Ebrantil), a sympatholytic antihypertensive drug, acts as a 5-HT1A receptor agonist and as an α1-adrenoceptor antagonist. | |||
T0162 | Quetiapine | ICI204636,Quetiapin | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor |
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... | |||
T2631 | WAY-100635 Maleate | Dopamine Receptor , 5-HT Receptor | |
WAY-100635 is a specific and effective 5-HT receptor antagonist (IC50=0.95 nM). | |||
T39161 | Ro60-0175 | Ro60-0175 | 5-HT Receptor |
Ro60-0175 a selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B recept... | |||
T21337 | Lurasidone | SM-13496 | Dopamine Receptor , 5-HT Receptor |
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM). | |||
T15270 | Fananserin | RP 62203 | Dopamine Receptor , 5-HT Receptor |
Fananserin is an effective, selective and oral active antagonist of 5-HT2 (Ki = 0.37 nM for the rat 5-HT2A). Fananserin is an antagonist of human D4 receptor (Ki = 2.93 nM). | |||
T4568 | Dolasetron | MDL-73147 | 5-HT Receptor |
Dolasetron (MDL-73147)(MDL-73147) is a serotonin 5-HT3 receptor antagonist. Dolasetron is used to treat nausea and vomiting following chemotherapy. | |||
T4616 | Metoclopramide | 5-Chloro-2-methoxyprocainamide | Dopamine Receptor , 5-HT Receptor |
Metoclopramide (5-Chloro-2-methoxyprocainamide) is a dopamine D2 antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In various countries, metoclopramide is ... | |||
T11217 | Eplivanserin | SR-46349 | 5-HT Receptor |
Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane. | |||
T13275 | Vabicaserin hydrochloride | SCA 136 | 5-HT Receptor |
Vabicaserin hydrochloride (SCA 136) is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM). | |||
T12172 | NAN-190 hydrobromide | 5-HT Receptor | |
NAN-190 hydrobromide is an antagonist of serotonin receptor 5-HT. | |||
T21011 | Buspirone | Buspirone free base,Ansial | 5-HT Receptor |
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. | |||
T0088 | Urapidil hydrochloride | Urapidil HCl | 5-HT Receptor , Adrenergic Receptor |
Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. | |||
T16421 | P-MPPI hydrochloride | 5-HT Receptor | |
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects. | |||
T0137 | Mirtazapine | 6-Azamianserin,Org3770 | Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor |
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h... | |||
T3179 | Eptapirone | F 11440 | 5-HT Receptor |
Eptapirone (F 11440) is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential. | |||
T22671 | CJ 033466 | 5-HT Receptor | |
CJ 033466 is a selective partial agonist of 5-HT4 receptor (EC50 = 9 nM) with gastroprokinetic effect. | |||
T1442 | Pizotifen | Pizotyline,BC-105 | 5-HT Receptor |
Pizotifen (Pizotyline) is a strong serotonin and tryptamine antagonist, with weak anticholinergic, anti-histaminic and anti-kinin effects. It also possesses sedative and appetite-stimulating properties. Pizotifen hydroch... | |||
T16759 | Ritanserin | R 55667 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor |
Ritanserin (R 55667) is a highly effective, relatively selective, long-acting antagonist of 5-HT2 receptor (IC50: 0.9 nM), less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2209 | Serotonin hydrochloride | 5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride | 5-HT Receptor , Endogenous Metabolite , Transferase |
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM). | |||
TN2437 | Serotonin | 5-hydroxytryptamine,5-HT | Others , 5-HT Receptor , Endogenous Metabolite , Transferase |
Serotonin (5-hydroxytryptamine) is a natural product from animals | |||
T2815 | Puerarin | Kakonein | 5-HT Receptor |
Puerarin (Kakonein), also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. It is a 5-HT2C receptor antagonist. | |||
T9113 | Myristicin | Myristicine | IL Receptor , Anti-infection , BCL , P450 , PARP , 5-HT Receptor , Caspase , GABA Receptor , NO Synthase |
Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with ... | |||
T0525 | Flopropione | Phloropropiophenone | 5-HT Receptor , Transferase |
Flopropione (Phloropropiophenone), a spasmolytic or antispasmodic agent, is used as a 5-HT1A receptor antagonist. | |||
T6S0654 | Isocorynoxeine | 7-Isocorynoxeine | 5-HT Receptor |
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... | |||
TN1217 | 2'-O-Methylisoliquiritigenin | Dopamine Receptor , 5-HT Receptor , GABA Receptor | |
2'-O-Methylisoliquiritigenin, a compound synthesized by enzymes specifically induced in NR.2'-O-Methylisoliquiritigenin, isolated from the Arachis species, up-regulates 5-HT, NE, DA and GABA pathways, but does not put a ... | |||
TN1465 | Cannabigerol | NOS , 5-HT Receptor , ROS | |
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur... | |||
TN1032 | Geissoschizine methyl ether | 5-HT Receptor | |
Geissoschizine methyl ether, a major indole alkaloid found in Uncaria hook, is a major active component of Yokukansan with psychotropic effects. Geissoschizine methyl ether is a potent serotonin A receptor agonist and ca... | |||
T4S1637 | Gamma-Mangostin | Normangostin | Others , 5-HT Receptor |
1. gamma-Mangostin (Normangostin) as a preventive agent of the metabolic syndrome. 2. Gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells. 3. Gamma-Mangostin ... | |||
T1045 | Trimipramine maleate | Surmontil maleate | Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Norepinephrine , Histamine Receptor |
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal... | |||
T6648 | Rotundine | Gindarine,L-Tetrahydropalmatine,Caseanine,(-)-Tetrahydropalmatine | Dopamine Receptor , 5-HT Receptor |
Rotundine (Gindarine) (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. | |||
T4S1659 | Xanthotoxol | 8-Hydroxypsoralen,8-Hydroxyfuranocoumarin,Psoralen,8-Hydroxypsoralene | Reactive Oxygen Species , 5-HT Receptor , Endogenous Metabolite |
Xanthotoxol (Psoralen) is a biologically active linear furocoumarin, shows strong pharmacological activities as anti-inflammatory, antioxidant, 5-HT antagonistic, and neuroprotective effects. | |||
T3369 | Nuciferine | (-)-Nuciferine,VLT 049,Sanjoinine E | Dopamine Receptor , 5-HT Receptor |
Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. | |||
T0076 | Paliperidone | 9-hydroxyrisperidone | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor |
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older... | |||
T19931 | Gentisein | NSC 329491,NSC329491,NSC-329491 | Serotonin Transporter |
Gentisein (NSC-329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2] | |||
T1711 | Harmine | Telepathine | MAO , 5-HT Receptor , DYRK |
Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala. | |||
T2811 | Harmine hydrochloride | telepathine hydrochloride | 5-HT Receptor , DYRK , GluR |
Harmine hydrochloride (telepathine hydrochloride) is extracted from Peganum Harmala Genus. | |||
T3933 | Jatrorrhizine | Yatrorizine,neprotin | MAO , 5-HT Receptor , Antibacterial , AChE |
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo... | |||
T4912 | Jatrorrhizine chloride | Yatrorhizine chloride,Neprotine chloride | Others , 5-HT Receptor , OCT , Antibacterial , AChE |
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h... | |||
TN2865 | (E)-3,4,5-Trimethoxycinnamic acid | O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid | Others |
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05308 | CD45 Protein, Human, Recombinant (aa 1-529, His) | Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu... | |||
TMPY-05387 | SLAMF7 Protein, Human, Recombinant (hFc) | Human | HEK293 |
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ... | |||
TMPY-05498 | SR-BI/SCARB1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Scavenger receptor class B, member 1 (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. SCARB1 is expressed primarily in liver and non placental steroidogenic tissues, and predominantly localiz... | |||
TMPJ-00854 | ETS1 Protein, Human, Recombinant (His) | Human | E. coli |
ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or ... | |||
TMPY-05547 | SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated | Human | HEK293 |
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 ... | |||
TMPY-04318 | GRIK2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar... | |||
TMPK-01363 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl... | |||
TMPK-01357 | SIRP alpha V5 Protein, Human, Recombinant (His & Avi) | Human | HEK293 |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadl... |
Cat No. | Product Name | ||
---|---|---|---|
L2800 | Serotonin Receptor-Targeted Compound Library | 275 compounds | |
A unique collection of 275 compounds targeting serotonin receptors for high throughput screening and high content screening; | |||
L2610 | Neurotransmitter Receptor Compound Library | 1513 compounds | |
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening; |