5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.

Cat. No.	Product name	CAS No.	Purity
T0039	Dapoxetine	119356-77-3	99.76%
T0039	Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
T62269	F 14679	208109-38-0	99.09%
T62269	F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.
T28414	Piclozotan	182415-09-4	99%
T28414	Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) mod...
T4348	Syk Inhibitor II	726695-51-8	97.63%
T4348	Syk inhibitor II, a cell-permeable, ATP-competitive, pyrimidine-carboxamide compound, selectively and reversibly inhibits Syk (IC50 = 41 nM).
T11217	Eplivanserin	130579-75-8	97.04%
T11217	Eplivanserin (SR-46349) is an effective and selective antagonist of 5-HT2A receptor with a Kd of 1.14 nM and an IC50 value of 5.8 nM in rat cortical membrane.
T1769	Pardoprunox	269718-84-5
T1769	Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials st...
TN1415	Auraptenol	1221-43-8	98%
TN1415	Auraptenol possesses robust antidepressant-like efficacy in mice.
T15100	Desmethyl cariprazine	839712-15-1	98%
T15100	Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (K...
T17095	TIK-301	118702-11-7	98%
T17095	TIK-301 is a chlorinated melatonin derivative and a potent, high-affinity, and orally active melatonin MT1 and MT2 receptors agonist (Kis: 0.081 nM and 0.042 nM,...
T19381	Isobutyryl-L-carnitine	25518-49-4	98%
T19381	Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
T13339	Wf-516	310392-94-0	98%
T13339	Wf-516 is a 5-HT reuptake inhibitor (Kis: 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively), and with potent antidepressant activit...
TN4713	Onitisin	53823-03-3	98%
TN4713	Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
T10380	AS19	1000578-26-6	98%
T10380	AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Ki...
T78228	4-Chloro-L-phenylalanine	14173-39-8	98%
T78228	4-Chloro-L-phenylalanine (L-PCPA) is an inhibitor of 5-HT biosynthesis.4-Chloro-L-phenylalanine is also a non-specific antagonist of tryptophan hydroxylase (TPH1...
T78684	FFN246	2210244-83-8	98%
T78684	FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emiss...
T79155	5-HT2A receptor agonist-3	1391499-52-7	98%
T79155	5-HT2A receptor agonist-3 represents the highest selectivity for the human 5-HT2A receptor currently identified, exhibiting a K i of 2.5 nM. It also demonstrates...
T79325	5-HT6 agonist 1		98%
T79325	Compound 19, a 5-HT6 agonist with an affinity (K i : 5 nM), exhibits antidepressant-like effects and enhances cognitive function while also inhibiting platelet a...
T79326	MRS7925		98%
T79326	MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosis [...
T79524	JPC0323		98%
T79524	JPC0323 is a dual positive allosteric modulator of the 5-HT2C and 5-HT2A receptors, featuring on-target properties, acceptable plasma exposure, and adequate brai...
T79684	5-HT6R antagonist 1		98%
T79684	Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability bu...