5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.

Cat. No.	Product name	CAS No.	Purity
T79684	5-HT6R antagonist 1		98%
T79684	Compound 8 (5-HT6R antagonist 1), a 5-HT6R antagonist (K i : 5 nM), not only demonstrates inhibition of platelet aggregation and excellent metabolic stability bu...
T79802	5-HT2C agonist-3	2104810-18-4	98%
T79802	5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced hyperactivi...
T79803	5-HT2C agonist-3 free base	2104810-17-3	98%
T79803	5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-indu...
T79804	5-HT2 agonist-1	2708279-78-9	98%
T79804	Compound 24, a 5-HT2 agonist-1, selectively activates 5-HT2A, 5-HT2B, and 5-HT2C receptors with IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respectively. The free ...
T79805	5-HT2 agonist-1 free base	2708279-77-8	98%
T79805	Compound 24 (5-HT2 agonist-1 free base) is a potent agonist for 5-HT2A, 5-HT2B, and 5-HT2C receptors, exhibiting IC50 values of 10 nM, 8.3 nM, and 1.6 nM, respec...
T79806	5-HT2A&5-HT2C agonist-1	1640-02-4	98%
T79806	5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM. It is appl...
T79838	(S)-Bexicaserin	2035818-21-2	98%
T79838	(S)-Bexcaserin (compound 2) serves as a 5-HT2C receptor agonist, presenting research possibilities in obesity and psychiatric disorders [1].
T15026	Cyamemazine	3546-03-0	98%
T15026	Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM)...
T81335	PZ-1922		98%
T81335	PZ-1922 (Compound 16), able to cross the blood-brain barrier, is a dual antagonist for 5-HT6R and 5-HT3R with K i values of 17 nM and 0.45 nM, respectively. It a...
T12262L	NPS ALX Compound 4a dihydrochloride	1781934-44-8	98%
T12262L	NPS ALX Compound 4a dihydrochloride is a potent and selective antagonist of 5-HT6 receptor (IC50 of 7.2 nM)
T10114	3-Hydroxy agomelatine	166526-99-4	98%
T10114	3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
TN3393	Alpha-Yohimbine	131-03-3	98%
TN3393	Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.
T12716	RG-12915	136174-04-4	98%
T12716	RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
T12859	SB 243213 hydrochloride	200940-23-4	98%
T12859	SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has...
T11216	Eplivanserin (mixture)	130581-13-4	98%
T11216	Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist,
T16683	Pumosetrag Hydrochloride	194093-42-0	98%
T16683	Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux ...
T12046	Mirtazapine D3	1216678-68-0	98%
T12046	Mirtazapine D3 is a deuterium labeled Mirtazapine. Mirtazapine is an inhibitor of 5-HT receptor .
T10612	Brexpiprazole S-oxide	1191900-51-2	98%
T10612	Brexpiprazole S-oxide (DM-3411) is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM an...
T6959	PRX-08066 Maleic acid	866206-55-5	98%
T6959	PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 of 3.4 nM, prevents the severity of pulmonary arterial hypertension in the MCT rat mode...
T12806	(S)-Mirtazapine D3	T12806	98%
T12806	(S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by C...