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5-HT Receptor

5-hydroxytryptamine receptors or 5-HT receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2116 Pteropodine 5629-60-7 98%
Pteropodine
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
T10996 Deramciclane 120444-71-5 98%
Deramciclane
Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C ...
T17253 WAY 163909 428868-32-0 98%
WAY 163909
WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM).
T15552 Iferanserin 58754-46-4 98%
Iferanserin
Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential fo...
T22921 LE 300 274694-98-3 98%
LE 300
dopamine D1 receptor antagonist
TN1755 Hyperforin 11079-53-1 98%
Hyperforin
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
T22340 Granisetron 109889-09-0 98%
Granisetron
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
T10192 7-Desmethyl-3-hydroxyagomelatine 166527-00-0 98%
7-Desmethyl-3-hydroxyagomelatine
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5...
T26622 Ampreloxetine 1227056-84-9 98%
Ampreloxetine
Ampreloxetine (TD-9855) is a norepinephrine reuptake inhibitor used to study neurological diseases.
T16399 Opiranserin 1441000-45-8 98%
Opiranserin
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T10294 AM9405 T10294 98%
AM9405
AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. AM9405 inhibits twitch contraction of the ileum and the col...
T12843 SB-399885 hydrochloride 402713-81-9 98%
SB-399885 hydrochloride
SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
T16556 PNU-142633 187665-65-2 98%
PNU-142633
PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor...
T10611 Brexpiprazole S-oxide D8 2748605-29-8 98%
Brexpiprazole S-oxide D8
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is...
T10344 AP521 151227-08-6 98%
AP521
AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).
TN1790 Isopteropodine 5171-37-9 98%
Isopteropodine
Isopteropodine (Uncarine E) is an isoyohimbine-type octindole alkaloid isolated from Hamelia patens micropropagated and has antimicrobial activity and stimulates...
T21360 Asenapine 65576-45-6 98%
Asenapine
Asenapine (Org 5222) is a 5-HT receptor, adrenergic receptor, dopamine receptor, and histamine receptor antagonist with antipsychotic effects that is used to tre...
T12631 (R)-Mirtazapine D3 T12631 98%
(R)-Mirtazapine D3
(R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor.
T10267 Agomelatine (L(+)-Tartaric acid) 824393-18-2 98%
Agomelatine (L(+)-Tartaric acid)
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and ...
T10498 5-HT2A antagonist 1 204643-75-4 98%
5-HT2A antagonist 1
5-HT2A antagonist 1 is a 5-HT2A antagonist. It may be useful in the treatment of gastrointestinal disorders circulatory disorders.
Pteropodine
TN2116
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
Deramciclane
T10996
Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. It acts as an antagonist in both receptor subtypes and has inverse agonist properties for 5-HT2C ...
WAY 163909
T17253
WAY 163909 is an effective and selective agonist of the 5-HT(2C) receptor (Ki: 10.5±1.1 nM).
Iferanserin
T15552
Iferanserin (S-MPEC) is a selective antagonist of the 5-HT receptor (serotonin receptor) with an affinity for 5-HT2A receptors. Iferanserin has the potential fo...
LE 300
T22921
dopamine D1 receptor antagonist
Hyperforin
TN1755
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
Granisetron
T22340
Granisetron, a serotonin receptor (5HT-3 selective) antagonist, is used as an antinauseant and antiemetic for cancer chemotherapy.
7-Desmethyl-3-hydroxyagomelatine
T10192
7-Desmethyl-3-hydroxyagomelatine is a metabolite of Agomelatine and has less activity than Agomelatine. Agomelatine is a melatonergic (MT1 and MT2) agonist and 5...
Ampreloxetine
T26622
Ampreloxetine (TD-9855) is a norepinephrine reuptake inhibitor used to study neurological diseases.
Opiranserin
T16399
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
AM9405
T10294
AM9405 is a novel peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist. AM9405 inhibits twitch contraction of the ileum and the col...
SB-399885 hydrochloride
T12843
SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.
PNU-142633
T16556
PNU-142633 has anti-migraine efficacy. PNU-142633 is a high affinity and selective 5-HT1D receptor agonist (Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor...
Brexpiprazole S-oxide D8
T10611
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is...
AP521
T10344
AP521 is an agonist of the human 5-HT1A receptor (IC50: 94 nM).
Isopteropodine
TN1790
Isopteropodine (Uncarine E) is an isoyohimbine-type octindole alkaloid isolated from Hamelia patens micropropagated and has antimicrobial activity and stimulates...
Asenapine
T21360
Asenapine (Org 5222) is a 5-HT receptor, adrenergic receptor, dopamine receptor, and histamine receptor antagonist with antipsychotic effects that is used to tre...
(R)-Mirtazapine D3
T12631
(R)-Mirtazapine D3 is a deuterium labeled (R)-Mirtazapine.(R)-Mirtazapine is a antagonist of 5-HT3 receptor.
Agomelatine (L(+)-Tartaric acid)
T10267
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and ...
5-HT2A antagonist 1
T10498
5-HT2A antagonist 1 is a 5-HT2A antagonist. It may be useful in the treatment of gastrointestinal disorders circulatory disorders.
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TargetMol