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Search Results for " acat "

Targets

68

Compounds

18

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10503 ACAT-IN-1 cis isomer Acyltransferase
ACAT-IN-1 cis isomer is a potent ACAT inhibitor (IC50: 100 nM) for the study of immune system-related diseases.
T39412 ACAT-IN-5
ACAT-IN-5 (example 19) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By inhibiting ACAT, this compound effectively suppresses the transcription mediated by NF-κB.
T40551 ACAT-IN-3
ACAT-IN-3, a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), effectively suppresses NF-κB dependent transcription.
T40552 ACAT-IN-10
ACAT-IN-10 is an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. It inhibits NF-κB mediated transcription with a weak activity.
T40553 ACAT-IN-6
ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription.
T39415 ACAT-IN-9
ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription.
T39414 ACAT-IN-7
ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB.
T40554 ACAT-IN-4
ACAT-IN-4 (Example 208) is a chemical compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). Additionally, ACAT-IN-4 effectively inhibits the transcription process mediated by NF-...
T39417 ACAT-IN-2
ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription.
T39413 ACAT-IN-8
ACAT-IN-8 (example 206) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation. This compound also possesses the ability to inhib...
T39411 ACAT-IN-10 dihydrochloride
ACAT-IN-10 dihydrochloride is a compound that serves as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT).ACAT-IN-10 dihydrochloride effectively hampers NF-κB mediated transcription, albeit to a lesser ...
T39416 ACAT-IN-4 hydrochloride
ACAT-IN-4 hydrochloride (Example 208) is a hydrochloride salt of a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively hinders NF-κB mediated transcription.
T22665 PD 128042 CI 976 Acyltransferase
PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multi...
T2753 Avasimibe PD-148515,CI-1011 P450 , Acyltransferase
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz...
T1239 Indacaterol maleate QAB149 Adrenergic Receptor
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
T2320 Indacaterol Adrenergic Receptor
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.
T6035 Odanacatib MK-0822 Cysteine Protease
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
T6078 Saracatinib AZD0530 EGFR , Src , BTK , Autophagy
Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.
T26548 Acaterin
Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774.
T71658 Indacaterol xinafoate
Indacaterol xinafoate is an ultra-long-acting beta-adrenoceptor agonist.
T71659 Indacaterol acetate
Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist.
T69475 Dinalbuphine sebacate
Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor.
T31461 Dihexyldecyl sebacate (+/-)-Dihexyldecyl sebacate,Decanedioic acid, bis(2-hexyldecyl) ester
Dihexyldecyl sebacate is a biochemical.
T21160 Dibenzyl sebacate Sebacic Acid Dibenzyl Ester,Decanedioic Acid Dibenzyl Ester
Dibenzyl sebacate is a biochemical.
T68425 Saracatinib difumarate
Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.
T71340 Mizagliflozin sebacate
Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from...
T31528 Disodium sebacate Sebacic Acid Disodium Salt,Decanedioic Acid Disodium Salt,Disodium Decanedioate
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. It has low toxicity.
T31515 Dipentyl sebacate Sebacinsaeurediphenylester,Diphenyl-sebacinat,Decandisaeure-diphenylester,Sebacinsaeure-diphenylester
Dipentyl sebacate is a biochemical.
T34069 Piperazine sebacate Nematorazine
Piperazine sebacate has anthelminthic activity. it be studie for therapy of trichocephalosis.
T30464 Bis(2-butoxyethyl) sebacate ecanedioic acid, bis(2-butoxyethyl) ester,Dibutyoxyethyl sebacate,Decanedioic acid, 1,10-bis(2-butoxyethyl) ester
Bis(2-butoxyethyl) sebacate is a biochemical.
T131567 Epicatechin (Epicatechol; Acacatechin; Kakaol)
Epicatechin (Epicatechol; Acacatechin; Kakaol) is a useful organic compound for research related to life sciences and the catalog number is T131567.
T21162 Diisooctyl sebacate Decanedioic acid,diisooctyl ester
Diisooctyl sebacate is a biochemical.
T21236 Monomethyl sebacate Decanoic acid, monomethyl ester,Methyl hydrogen sebacate
Monomethyl sebacate is a biochemical.
T31111 Cupric sebacate
Cupric sebacate is a biochemical.
T71660 Indacaterol fumarate
Indacaterol fumarate is an ultra-long-acting beta-adrenoceptor agonist.
T31506 Dioctyldodecyl sebacate (+/-)-Dioctyldodecyl sebacate,Bis(2-octyldodecyl) sebacate
Dioctyldodecyl sebacate is a biochemical.
T40463 Relacatib SB-462795
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac...
T12767 RP 70676 Acyltransferase
RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ).
T14523 Beauvericin Others , Acyltransferase
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM.
T13373 YM17E Acyltransferase , AChR
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro.
T23550 YM-750 YM 750 Acyltransferase
YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A.
T8314 RP-64477 RP64477 Acyltransferase
RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor.
T16928 SR144528 Cannabinoid Receptor
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).
T25651 Lecimibide DuP128,DuP-128,DuP 128 Acyltransferase
Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids.
T25635 Lateritin Bassiatin Acyltransferase
Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer.
T23521 VULM 1457 Acyltransferase
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of...
T15187 E-5324 Others
E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM).
T28290 Pactimibe CS 505,CS-505,CS505,Pactimibe free base
Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity.
T70575 AS 183
AS 183 is an inhibitor of cholesterol acyltransferase (ACAT).
T27376 FR-186054 FR186054,FR 186054
FR-186054 is a new, potent inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) and has oral activity. Compared to other ACAT inhibitors, this compound displayed excellent in vitro efficacy, irrespective of dosing ...

Compounds

ACAT-IN-1 cis isomer
T10503
Synonym:
Target: Acyltransferase
ACAT-IN-5
T39412
Synonym:
Target:
ACAT-IN-3
T40551
Synonym:
Target:
ACAT-IN-10
T40552
Synonym:
Target:
ACAT-IN-6
T40553
Synonym:
Target:
ACAT-IN-9
T39415
Synonym:
Target:
ACAT-IN-7
T39414
Synonym:
Target:
ACAT-IN-4
T40554
Synonym:
Target:
ACAT-IN-2
T39417
Synonym:
Target:
ACAT-IN-8
T39413
Synonym:
Target:
ACAT-IN-10 dihydrochloride
T39411
Synonym:
Target:
ACAT-IN-4 hydrochloride
T39416
Synonym:
Target:
PD 128042
T22665
Synonym: CI 976
Target: Acyltransferase
Avasimibe
T2753
Synonym: PD-148515,CI-1011
Target: P450, Acyltransferase
Indacaterol maleate
T1239
Synonym: QAB149
Target: Adrenergic Receptor
Indacaterol
T2320
Synonym:
Target: Adrenergic Receptor
Odanacatib
T6035
Synonym: MK-0822
Target: Cysteine Protease
Saracatinib
T6078
Synonym: AZD0530
Target: EGFR, Src, BTK, Autophagy
Acaterin
T26548
Synonym:
Target:
Indacaterol xinafoate
T71658
Synonym:
Target:
Indacaterol acetate
T71659
Synonym:
Target:
Dinalbuphine sebacate
T69475
Synonym:
Target:
Dihexyldecyl sebacate
T31461
Synonym: (+/-)-Dihexyldecyl sebacate,Decanedioic acid, bis(2-hexyldecyl) ester
Target:
Dibenzyl sebacate
T21160
Synonym: Sebacic Acid Dibenzyl Ester,Decanedioic Acid Dibenzyl Ester
Target:
Saracatinib difumarate
T68425
Synonym:
Target:
Mizagliflozin sebacate
T71340
Synonym:
Target:
Disodium sebacate
T31528
Synonym: Sebacic Acid Disodium Salt,Decanedioic Acid Disodium Salt,Disodium Decanedioate
Target:
Dipentyl sebacate
T31515
Synonym: Sebacinsaeurediphenylester,Diphenyl-sebacinat,Decandisaeure-diphenylester,Sebacinsaeure-diphenylester
Target:
Piperazine sebacate
T34069
Synonym: Nematorazine
Target:
Bis(2-butoxyethyl) sebacate
T30464
Synonym: ecanedioic acid, bis(2-butoxyethyl) ester,Dibutyoxyethyl sebacate,Decanedioic acid, 1,10-bis(2-butoxyethyl) ester
Target:
Epicatechin (Epicatechol; Acacatechin; Kakaol)
T131567
Synonym:
Target:
Diisooctyl sebacate
T21162
Synonym: Decanedioic acid,diisooctyl ester
Target:
Monomethyl sebacate
T21236
Synonym: Decanoic acid, monomethyl ester,Methyl hydrogen sebacate
Target:
Cupric sebacate
T31111
Synonym:
Target:
Indacaterol fumarate
T71660
Synonym:
Target:
Dioctyldodecyl sebacate
T31506
Synonym: (+/-)-Dioctyldodecyl sebacate,Bis(2-octyldodecyl) sebacate
Target:
Relacatib
T40463
Synonym: SB-462795
Target:
RP 70676
T12767
Synonym:
Target: Acyltransferase
Beauvericin
T14523
Synonym:
Target: Others, Acyltransferase
YM17E
T13373
Synonym:
Target: Acyltransferase, AChR
YM-750
T23550
Synonym: YM 750
Target: Acyltransferase
RP-64477
T8314
Synonym: RP64477
Target: Acyltransferase
SR144528
T16928
Synonym:
Target: Cannabinoid Receptor
Lecimibide
T25651
Synonym: DuP128,DuP-128,DuP 128
Target: Acyltransferase
Lateritin
T25635
Synonym: Bassiatin
Target: Acyltransferase
VULM 1457
T23521
Synonym:
Target: Acyltransferase
E-5324
T15187
Synonym:
Target: Others
Pactimibe
T28290
Synonym: CS 505,CS-505,CS505,Pactimibe free base
Target:
AS 183
T70575
Synonym:
Target:
FR-186054
T27376
Synonym: FR186054,FR 186054
Target:
1 2
Cat No. Product Name Synonyms Targets
T8010 Dibutyl sebacate Dibutyl decanedioate Others
Dibutyl sebacate (Dibutyl decanedioate) is an organic chemical which is mainly used as a plasticizer in the production of plastics.
T21159 Bis(2-ethylhexyl) sebacate Di(2-ethylhexyl) Sebacate,Dioctyl Sebacate
Bis(2-ethylhexyl) sebacate is used as a plasticizer in preparing ion-selective electrodes. It is an important raw material and intermediate used in organic synthesis, agrochemicals, pharmaceuticals and dyestuff fields.
T30683 Cadmium sebacate
Cadmium sebacate is a biochemical.
TN1691 Glabrol P450 , NF-κB , NO Synthase , Acyltransferase
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM.
T36776 Terpendole C
Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It ...
T29329 24-Methylenecholesterol 24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,Ostreasterol Acyltransferase
24-Methylenecholesterol (24 Methylenecholesterol) is a natural marine sterol, which stimulates cholesterol acyl transferase (ACAT) in human macrophages.
T13678 Enniatin A
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes.
T75552 Pomonic acid
Pomonic acid is a triterpenoid that significantly inhibits cholesterol ester accumulation and suppresses the acyl coenzyme A:cholesterol acyltransferase ( ACAT ) activity [1] .
T36931 Penicillide
Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (A...
T13679 Enniatin B ERK
Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liv...
T75696 Ilexoside XLVIII
Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase ( ACAT ) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha [1] .
TN2834 27-p-Coumaroyloxyursolic acid Others
27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay.
T13680 Enniatin B1 ERK
Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits ...
T11201 Enniatin A1 ERK
Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes. Enniatin A1 isolated from Fus...
T36329 Terpendole I
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and ...
T36227 Beauveriolide III
Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cho...
T36226 Beauveriolide I
Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits chole...
T37690 Phenylpyropene A
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM)....

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-06754 CES1 Protein, Human, Recombinant (His) Human HEK293
CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Variants generated by the exchange of segments with CES1P1 complicate the genotyping of CES1. CES1 is involved in ...
TMPJ-01302 ACAT2 Protein, Human, Recombinant (His) Human E. coli
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesi...
TMPY-04813 ACAT2 Protein, Rat, Recombinant (His) Rat E. coli
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e...
TMPH-00875 ACAT1 Protein, Human, Recombinant (His) Human E. coli
TargetMol