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Cat No. | Product Name | Synonyms | Targets |
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T10503 | ACAT-IN-1 cis isomer | Acyltransferase | |
ACAT-IN-1 cis isomer is a potent ACAT inhibitor (IC50: 100 nM) for the study of immune system-related diseases. | |||
T39412 | ACAT-IN-5 | ||
ACAT-IN-5 (example 19) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By inhibiting ACAT, this compound effectively suppresses the transcription mediated by NF-κB. | |||
T40551 | ACAT-IN-3 | ||
ACAT-IN-3, a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), effectively suppresses NF-κB dependent transcription. | |||
T40552 | ACAT-IN-10 | ||
ACAT-IN-10 is an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. It inhibits NF-κB mediated transcription with a weak activity. | |||
T40553 | ACAT-IN-6 | ||
ACAT-IN-6, an acyl-Coenzyme A: cholesterol acyltransferase (ACAT) inhibitor, displays potent inhibition of NF-κB mediated transcription. | |||
T39415 | ACAT-IN-9 | ||
ACAT-IN-9, acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). By doing so, it effectively suppresses NF-κB mediated transcription. | |||
T39414 | ACAT-IN-7 | ||
ACAT-IN-7 is a compound that acts as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT) enzyme. It effectively suppresses the transcription process mediated by NF-κB. | |||
T40554 | ACAT-IN-4 | ||
ACAT-IN-4 (Example 208) is a chemical compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). Additionally, ACAT-IN-4 effectively inhibits the transcription process mediated by NF-... | |||
T39417 | ACAT-IN-2 | ||
ACAT-IN-2 is a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively blocks NF-κB mediated transcription. | |||
T39413 | ACAT-IN-8 | ||
ACAT-IN-8 (example 206) is a compound that functions as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT), an enzyme involved in cholesterol modulation. This compound also possesses the ability to inhib... | |||
T39411 | ACAT-IN-10 dihydrochloride | ||
ACAT-IN-10 dihydrochloride is a compound that serves as an inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT).ACAT-IN-10 dihydrochloride effectively hampers NF-κB mediated transcription, albeit to a lesser ... | |||
T39416 | ACAT-IN-4 hydrochloride | ||
ACAT-IN-4 hydrochloride (Example 208) is a hydrochloride salt of a potent inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT). This compound effectively hinders NF-κB mediated transcription. | |||
T22665 | PD 128042 | CI 976 | Acyltransferase |
PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multi... | |||
T2753 | Avasimibe | PD-148515,CI-1011 | P450 , Acyltransferase |
Avasimibe (PD-148515) is an orally bioavailable inhibitor of acyl-Coenzyme A: cholesterol acyltransferase (ACAT, IC50: 3.3 μM) that prevents cholesterol deposition in the arterial wall. It also inhibits human P450 isoenz... | |||
T1239 | Indacaterol maleate | QAB149 | Adrenergic Receptor |
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist. | |||
T2320 | Indacaterol | Adrenergic Receptor | |
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist. | |||
T6035 | Odanacatib | MK-0822 | Cysteine Protease |
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity. | |||
T6078 | Saracatinib | AZD0530 | EGFR , Src , BTK , Autophagy |
Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes. | |||
T26548 | Acaterin | ||
Acaterin, an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), inhibits synthesis of cholesteryl ester in macrophage J774. | |||
T71658 | Indacaterol xinafoate | ||
Indacaterol xinafoate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T71659 | Indacaterol acetate | ||
Indacaterol acetate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T69475 | Dinalbuphine sebacate | ||
Dinalbuphine sebacate is a long-lasting prodrug of nalbuphine, acting as a moderate-efficacy partial agonist or antagonist of the μ-opioid receptor and as a high-efficacy partial agonist of the κ-opioid receptor. | |||
T31461 | Dihexyldecyl sebacate | (+/-)-Dihexyldecyl sebacate,Decanedioic acid, bis(2-hexyldecyl) ester | |
Dihexyldecyl sebacate is a biochemical. | |||
T21160 | Dibenzyl sebacate | Sebacic Acid Dibenzyl Ester,Decanedioic Acid Dibenzyl Ester | |
Dibenzyl sebacate is a biochemical. | |||
T68425 | Saracatinib difumarate | ||
Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. | |||
T71340 | Mizagliflozin sebacate | ||
Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from... | |||
T31528 | Disodium sebacate | Sebacic Acid Disodium Salt,Decanedioic Acid Disodium Salt,Disodium Decanedioate | |
Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. It has low toxicity. | |||
T31515 | Dipentyl sebacate | Sebacinsaeurediphenylester,Diphenyl-sebacinat,Decandisaeure-diphenylester,Sebacinsaeure-diphenylester | |
Dipentyl sebacate is a biochemical. | |||
T34069 | Piperazine sebacate | Nematorazine | |
Piperazine sebacate has anthelminthic activity. it be studie for therapy of trichocephalosis. | |||
T30464 | Bis(2-butoxyethyl) sebacate | ecanedioic acid, bis(2-butoxyethyl) ester,Dibutyoxyethyl sebacate,Decanedioic acid, 1,10-bis(2-butoxyethyl) ester | |
Bis(2-butoxyethyl) sebacate is a biochemical. | |||
T131567 | Epicatechin (Epicatechol; Acacatechin; Kakaol) | ||
Epicatechin (Epicatechol; Acacatechin; Kakaol) is a useful organic compound for research related to life sciences and the catalog number is T131567. | |||
T21162 | Diisooctyl sebacate | Decanedioic acid,diisooctyl ester | |
Diisooctyl sebacate is a biochemical. | |||
T21236 | Monomethyl sebacate | Decanoic acid, monomethyl ester,Methyl hydrogen sebacate | |
Monomethyl sebacate is a biochemical. | |||
T31111 | Cupric sebacate | ||
Cupric sebacate is a biochemical. | |||
T71660 | Indacaterol fumarate | ||
Indacaterol fumarate is an ultra-long-acting beta-adrenoceptor agonist. | |||
T31506 | Dioctyldodecyl sebacate | (+/-)-Dioctyldodecyl sebacate,Bis(2-octyldodecyl) sebacate | |
Dioctyldodecyl sebacate is a biochemical. | |||
T40463 | Relacatib | SB-462795 | |
Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V. It exhibits high affinity for these enzymes, with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Moreover, Relac... | |||
T12767 | RP 70676 | Acyltransferase | |
RP 70676 is a potent ACAT inhibitor(rat and rabbit ACAT with IC50 of 25 and 44 nM ). | |||
T14523 | Beauvericin | Others , Acyltransferase | |
Beauvericin, a Fusarium mycotoxin, inhibits acyl-CoA:cholesterol acyltransferase (ACAT) in rat liver microsomal enzyme assays with an IC50 value of 3 μM. | |||
T13373 | YM17E | Acyltransferase , AChR | |
YM17E is an inhibitor of ACAT with IC50 of 44 nM in rabbit liver microsomes in vitro. | |||
T23550 | YM-750 | YM 750 | Acyltransferase |
YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. | |||
T8314 | RP-64477 | RP64477 | Acyltransferase |
RP-64477 is the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT) inhibitor. | |||
T16928 | SR144528 | Cannabinoid Receptor | |
SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM). | |||
T25651 | Lecimibide | DuP128,DuP-128,DuP 128 | Acyltransferase |
Lecimibide (DuP 128) is a potent and selective inhibitor of acyl coenzyme A: cholesterol acyltransferase (ACAT), which can be used to study diseases due to high lipids. | |||
T25635 | Lateritin | Bassiatin | Acyltransferase |
Lateritin (Bassiatin) is An Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor and a platelet aggregation inhibitor from the mycelial cake of Gibberella lateritium. Bassiatin is the (3S,6R) isomer. | |||
T23521 | VULM 1457 | Acyltransferase | |
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of... | |||
T15187 | E-5324 | Others | |
E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM). | |||
T28290 | Pactimibe | CS 505,CS-505,CS505,Pactimibe free base | |
Pactimibe is a ACAT inhibitor. It has anti-atherosclerotic activity. | |||
T70575 | AS 183 | ||
AS 183 is an inhibitor of cholesterol acyltransferase (ACAT). | |||
T27376 | FR-186054 | FR186054,FR 186054 | |
FR-186054 is a new, potent inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) and has oral activity. Compared to other ACAT inhibitors, this compound displayed excellent in vitro efficacy, irrespective of dosing ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8010 | Dibutyl sebacate | Dibutyl decanedioate | Others |
Dibutyl sebacate (Dibutyl decanedioate) is an organic chemical which is mainly used as a plasticizer in the production of plastics. | |||
T21159 | Bis(2-ethylhexyl) sebacate | Di(2-ethylhexyl) Sebacate,Dioctyl Sebacate | |
Bis(2-ethylhexyl) sebacate is used as a plasticizer in preparing ion-selective electrodes. It is an important raw material and intermediate used in organic synthesis, agrochemicals, pharmaceuticals and dyestuff fields. | |||
T30683 | Cadmium sebacate | ||
Cadmium sebacate is a biochemical. | |||
TN1691 | Glabrol | P450 , NF-κB , NO Synthase , Acyltransferase | |
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15uM. | |||
T36776 | Terpendole C | ||
Terpendole C is an indole diterpene alkaloid fungal metabolite originally isolated from A. yamanashiensis and an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 2.1 μM in rat liver microsomes). It ... | |||
T29329 | 24-Methylenecholesterol | 24Methylenecholesterol,24 Methylenecholesterol,Chalinasterol,Ostreasterol | Acyltransferase |
24-Methylenecholesterol (24 Methylenecholesterol) is a natural marine sterol, which stimulates cholesterol acyl transferase (ACAT) in human macrophages. | |||
T13678 | Enniatin A | ||
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes. | |||
T75552 | Pomonic acid | ||
Pomonic acid is a triterpenoid that significantly inhibits cholesterol ester accumulation and suppresses the acyl coenzyme A:cholesterol acyltransferase ( ACAT ) activity [1] . | |||
T36931 | Penicillide | ||
Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (A... | |||
T13679 | Enniatin B | ERK | |
Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liv... | |||
T75696 | Ilexoside XLVIII | ||
Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase ( ACAT ) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha [1] . | |||
TN2834 | 27-p-Coumaroyloxyursolic acid | Others | |
27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay. | |||
T13680 | Enniatin B1 | ERK | |
Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits ... | |||
T11201 | Enniatin A1 | ERK | |
Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes. Enniatin A1 isolated from Fus... | |||
T36329 | Terpendole I | ||
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and ... | |||
T36227 | Beauveriolide III | ||
Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cho... | |||
T36226 | Beauveriolide I | ||
Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits chole... | |||
T37690 | Phenylpyropene A | ||
Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).... |
Cat No. | Product Name | Species | Expression System |
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TMPY-06754 | CES1 Protein, Human, Recombinant (His) | Human | HEK293 |
CES1 encodes carboxylesterase-1, an important drug-metabolizing enzyme with high expression in the liver. Variants generated by the exchange of segments with CES1P1 complicate the genotyping of CES1. CES1 is involved in ... | |||
TMPJ-01302 | ACAT2 Protein, Human, Recombinant (His) | Human | E. coli |
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesi... | |||
TMPY-04813 | ACAT2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e... | |||
TMPH-00875 | ACAT1 Protein, Human, Recombinant (His) | Human | E. coli |