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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13681 Epi-galantamine 1668-85-5 99.07%
Epi-galantamine
Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as a...
T62360 AChE-IN-26 99.04%
AChE-IN-26
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).
T3852 Rhodiosin 86831-54-1 98.96%
Rhodiosin
Rhodiosin is a compound with antioxidant activity.
T5S2361 Epiberberine 6873-09-2 98.95%
Epiberberine
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
T21556 Hydroxytacrine maleate 118909-22-1 98.84%
Hydroxytacrine maleate
Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase (cholinesterase) inhibitor that enhances memory in rodents and may be used in the study of Alzhei...
T32535 Ladostigil 209394-27-4 98.79%
Ladostigil
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO...
T20847 Thiobencarb 28249-77-6 98.68%
Thiobencarb
Thiobencarb (Siacarb), a thiocarbamate herbicide, is a cholinesterase inhibitor.
T3933 Jatrorrhizine 3621-38-3 98.59%
Jatrorrhizine
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and ant...
T11366 Garcinol 78824-30-3 98.59%
Garcinol
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
T40335 AChE-IN-3 2713548-95-7 98.59%
AChE-IN-3
AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.
T4439 Sn-Glycero-3-phosphocholine 28319-77-9 98.53%
sn-Glycero-3-phosphocholine
sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholi...
T22329 Ethyl (triphenylphosphoranylidene) acetate 1099-45-2 98.43%
Ethyl (triphenylphosphoranylidene) acetate
Ethyl (triphenylphosphoranylidene) acetate ((Carbethoxymethylene)triphenylphosphorane) may act as an cholinesterase inhibitor that inhibits AChE and BChE.
TN2443 Chikusetsusaponin Ib 59252-87-8 98.34%
Chikusetsusaponin Ib
Chikusetsusaponin Ib (Chikusetsu saponin Ib) is an inhibitor of AChE and can be used in studies about anti-Alzheimer's diseases.
T6S2356 Corynoline 18797-79-0 98.29%
Corynoline
1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.
T9862 Pseudocoptisine chloride 30044-78-1 98.17%
Pseudocoptisine chloride
Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride i...
T23131 PE 154 1192750-33-6 98.15%
PE 154
PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively. PE 154 is c...
T13469 (±)-Huperzine A 120786-18-7 98.14%
(±)-Huperzine A
(±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs. (±)-Huperzine A is a selective and reversible inhibitor of AChE and ca...
T3767 Polygalacic acid 22338-71-2 98.11%
Polygalacic acid
Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, inc...
T2845 Imperatorin 482-44-0 98.07%
Imperatorin
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and m...
T5S1408 Pteryxin 13161-75-6 98%
Pteryxin
(+)-Pteryxin ((+)-Pteryxin) has muscle-relaxant props. (+)-Pteryxin shows hepatoprotective and nitric oxide prodn. inhibitory activity.
Epi-galantamine
T13681
Epi-galantamine, a diastereomer of galantamine, is an alkaloid extracted from the bulbs and flowers of the Caucasian snowdrop (Galanthus woronowii). It acts as a...
AChE-IN-26
T62360
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).
Rhodiosin
T3852
Rhodiosin is a compound with antioxidant activity.
Epiberberine
T5S2361
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
Hydroxytacrine maleate
T21556
Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase (cholinesterase) inhibitor that enhances memory in rodents and may be used in the study of Alzhei...
Ladostigil
T32535
Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO...
Thiobencarb
T20847
Thiobencarb (Siacarb), a thiocarbamate herbicide, is a cholinesterase inhibitor.
Jatrorrhizine
T3933
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and ant...
Garcinol
T11366
Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-...
AChE-IN-3
T40335
AChE-IN-3 had inhibitory effect on AChE and stronger inhibitory effect on NO, with EC50 of 0.57 μM.
sn-Glycero-3-phosphocholine
T4439
sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholi...
Ethyl (triphenylphosphoranylidene) acetate
T22329
Ethyl (triphenylphosphoranylidene) acetate ((Carbethoxymethylene)triphenylphosphorane) may act as an cholinesterase inhibitor that inhibits AChE and BChE.
Chikusetsusaponin Ib
TN2443
Chikusetsusaponin Ib (Chikusetsu saponin Ib) is an inhibitor of AChE and can be used in studies about anti-Alzheimer's diseases.
Corynoline
T6S2356
1. Corynoline ((+)-Corynoline) is an acetylcholinesterase inhibitor.
Pseudocoptisine chloride
T9862
Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride i...
PE 154
T23131
PE 154 is a potent fluorescent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 280 pM and 16 nM respectively. PE 154 is c...
(±)-Huperzine A
T13469
(±)-Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbs. (±)-Huperzine A is a selective and reversible inhibitor of AChE and ca...
Polygalacic acid
T3767
Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, inc...
Imperatorin
T2845
Imperatorin (8-Isopentenyloxypsoralene) is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and m...
Pteryxin
T5S1408
(+)-Pteryxin ((+)-Pteryxin) has muscle-relaxant props. (+)-Pteryxin shows hepatoprotective and nitric oxide prodn. inhibitory activity.
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TargetMol