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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2S1720 Huperzine B 103548-82-9 98%
Huperzine B
1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for Al...
T21825 TAE-1 1414469-59-2 98%
TAE-1
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
T7640 Aldicarb sulfone 1646-88-4 98%
Aldicarb sulfone
Aldicarb sulfone is a cholinesterase inhibitor .
T3392 Sinapine thiocyanate 7431-77-8 98%
Sinapine thiocyanate
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
T5721 Dehydroevodiamine hydrochloride 111664-82-5 98%
Dehydroevodiamine hydrochloride
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitri...
T7114 GALANTHAMINONE 510-77-0 98%
GALANTHAMINONE
Galanthaminone ((-)-Narwedine) is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory i...
T7213 Demecarium bromide 56-94-0 98%
Demecarium bromide
Demecarium bromide (BC-48) is a potent cholinesterase inhibitor,and is treatment glaucoma agent.
T20812 Azamethiphos 35575-96-3 97.99%
Azamethiphos
Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.
T3872 Nodakenin 495-31-8 97.99%
Nodakenin
Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.
TN6786 O-Desmethyl Galanthamine 60755-80-8 97.86%
O-Desmethyl Galanthamine
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
T60739L Y13g dihydrochloride T60739L 97.81%
Y13g dihydrochloride
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are rela...
T6S0653 Linarin 480-36-4 97.81%
Linarin
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviate...
T13301 Violanthin 40581-17-7 97.81%
Violanthin
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxid...
TN6919 Methyl tridecanoate 1731-88-0 97.63%
Methyl tridecanoate
Methyl tridecanoate is a natural product.
T5S1025 Picfeltarraenin IA 97230-47-2 97.51%
Picfeltarraenin IA
1. Picfeltarraenin IA (Picfeltarraenin A), IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
T5855 Edrophonium chloride 116-38-1 97%
Edrophonium chloride
Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specific...
TN1899 Lycoramine 21133-52-8 96.19%
Lycoramine
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
T50066 1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide 6266-40-6 95.00%
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide is the inhibitor of human erythrocyte AChE.
T20539 Pirimiphos-methyl 29232-93-7 95%
Pirimiphos-methyl
Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is ...
T5S2343 Acetylshikonin 24502-78-1 92.45%
Acetylshikonin
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
Huperzine B
T2S1720
1. Huperzine-B is a efficient inhibitor of human brain AChE. 2. Huperzine-B can enhance ognitive and protect neuro, may be potentially new drug candidates for Al...
TAE-1
T21825
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Aldicarb sulfone
T7640
Aldicarb sulfone is a cholinesterase inhibitor .
Sinapine thiocyanate
T3392
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800)....
Dehydroevodiamine hydrochloride
T5721
Dehydroevodiamine (DHE), a natural compound isolated from Evodia rutaecarpa, can inhibit AChE. It has hypotensive and neuroprotective effects and modulates nitri...
GALANTHAMINONE
T7114
Galanthaminone ((-)-Narwedine) is a cholinesterase (AChE) inhibitor, is used for the treatment of mild to moderate Alzheimer's disease and various other memory i...
Demecarium bromide
T7213
Demecarium bromide (BC-48) is a potent cholinesterase inhibitor,and is treatment glaucoma agent.
Azamethiphos
T20812
Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.
Nodakenin
T3872
Nodakenin ((+)-Marmesinin) is a compound with anti-allergic and anti-inflammatory activities.
O-Desmethyl Galanthamine
TN6786
O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
Y13g dihydrochloride
T60739L
Y13g dihydrochloride is a potent inhibitor of interleukin 6 (IL-6) and acetylcholinesterase (AChE) (both targets of Alzheimer's disease (AD) progression are rela...
Linarin
T6S0653
1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviate...
Violanthin
T13301
Violanthin is a natural product isolated from the aerial parts of Piper bavinum and inhibits acetylcholinesterase (AChE) (IC50: 79.80 μM). It has potent antioxid...
Methyl tridecanoate
TN6919
Methyl tridecanoate is a natural product.
Picfeltarraenin IA
T5S1025
1. Picfeltarraenin IA (Picfeltarraenin A), IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.
Edrophonium chloride
T5855
Edrophonium chloride is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specific...
Lycoramine
TN1899
Lycoramine is a natural product isolated from Lycoris radiate. Lycoramine is a potent acetylcholinesterase (AChE) inhibitor
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide
T50066
1-[10-(pyridin-1-ium-1-yl)decyl]pyridin-1-ium dibromide is the inhibitor of human erythrocyte AChE.
Pirimiphos-methyl
T20539
Pirimiphos-methyl (AI3-27699) is a rapid-acting organophosphorus insecticide and acaricide, causing inhibition of AChE in target organisms. Pirimiphos-methyl is ...
Acetylshikonin
T5S2343
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
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TargetMol