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AChE

Acetylcholinesterase, also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acetylcholine and some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. It belongs to the carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5S2343 Acetylshikonin 24502-78-1 92.45%
Acetylshikonin
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
T1635 Fenchlorphos 299-84-3 100%
Fenchlorphos
Fenchlorphos (Dermafos) is a cholinesterase inhibitor, used as an insecticide.
T34399 Rovatirelin 204386-76-5 100%
Rovatirelin
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat m...
T2759 Loganin 18524-94-2 100%
Loganin
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has disp...
TN1528 Cotoin 479-21-0 100%
Cotoin
Cotoin is a natural product isolated from the stem bark of Garcinia virgate.Cotoin has antispasmodic activity and reduces the tone and contraction of isolated ra...
T3S1612 Kuwanon G 75629-19-5
kuwanon G
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective ...
T2319 Acotiamide monohydrochloride trihydrate 773092-05-0
Acotiamide monohydrochloride trihydrate
Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancin...
T5S2254 Swertianolin 23445-00-3
Swertianolin
1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic mar...
T0269 Dichlorisone Acetate 79-61-8
Dichlorisone Acetate
Dichlorisone Acetate (Diloderm) is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
TN2130 Manghaslin 55696-57-6
Manghaslin
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenoli...
TN2298 Vincosamide 23141-27-7
Vincosamide
Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can ...
T19084 1-Naphthyl acetate 830-81-9
1-Naphthyl acetate
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the det...
T0731 Diethyltoluamide 134-62-3
Diethyltoluamide
Diethyltoluamide (DEET) is the most general active composition in insect repellents.
Fr16605 Lupinine 486-70-4
Lupinine
Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Lora...
T0338 Minaprine 25905-77-5 98%
Minaprine
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
TN1403 Arjunolic acid 465-00-9 98%
Arjunolic acid
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
TC0022 Desoxypeganine 495-59-0 98%
Desoxypeganine
Desoxypeganine (Deoxypeganine) is an inhibitor of cholinesterase. It acting preferentially on butyrylcholinesterase, and as a selective inhibitor of monoamine ox...
T14194 β-NETA 31059-54-8 98%
β-NETA
β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like rec...
T72112 Clozapine N-oxide dihydrochloride 2250025-93-3 98%
Clozapine N-oxide dihydrochloride
Clozapine N-oxide dihydrochloride is a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs) that crosses the blood-brain barrier...
T8585 TA-03 5778-80-3 98%
TA-03
TA-03 (7-Meota) is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
Acetylshikonin
T5S2343
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and a...
Fenchlorphos
T1635
Fenchlorphos (Dermafos) is a cholinesterase inhibitor, used as an insecticide.
Rovatirelin
T34399
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat m...
Loganin
T2759
Loganin (Loganoside), an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also noted to suppress TNF-α formation. This compound also has disp...
Cotoin
TN1528
Cotoin is a natural product isolated from the stem bark of Garcinia virgate.Cotoin has antispasmodic activity and reduces the tone and contraction of isolated ra...
kuwanon G
T3S1612
1. Kuwanon G (Moracenin B) as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective ...
Acotiamide monohydrochloride trihydrate
T2319
Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancin...
Swertianolin
T5S2254
1. Swertianolin (Bellidifolin-8-O-Glucoside), mangiferin, rhodenthoside A-C, isoorientin, isovitexin, and amarogentin would serve as potential chemotaxonomic mar...
Dichlorisone Acetate
T0269
Dichlorisone Acetate (Diloderm) is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
Manghaslin
TN2130
Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenoli...
Vincosamide
TN2298
Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can ...
1-Naphthyl acetate
T19084
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages. 1-Naphthyl acetate is a potent chromogenic substrate for the det...
Diethyltoluamide
T0731
Diethyltoluamide (DEET) is the most general active composition in insect repellents.
Lupinine
Fr16605
Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Lora...
Minaprine
T0338
Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.
Arjunolic acid
TN1403
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
Desoxypeganine
TC0022
Desoxypeganine (Deoxypeganine) is an inhibitor of cholinesterase. It acting preferentially on butyrylcholinesterase, and as a selective inhibitor of monoamine ox...
β-NETA
T14194
β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like rec...
Clozapine N-oxide dihydrochloride
T72112
Clozapine N-oxide dihydrochloride is a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs) that crosses the blood-brain barrier...
TA-03
T8585
TA-03 (7-Meota) is a potent inhibitor of AChE in treatment of cognitive manifestation of AD.
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TargetMol