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AChR

An acetylcholine receptor (abbreviated AChR) is an integral membrane protein that responds to the binding of acetylcholine, a neurotransmitter.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T27579 ICL-CCIC-0019 936498-64-5 97.62%
ICL-CCIC-0019
ICL-CCIC-0019 is an inhibitor of choline kinase alpha (ChoKα). ICL-CCIC-0019 induces G1 arrest, endoplasmic reticulum stress, and apoptosis of cancer cell lines....
T12085 MN58b 203192-01-2 97.46%
MN58b
MN58b is a selective inhibitor of choline kinase α (CHKα).
T12653 (Rac)-ABT-202 dihydrochloride 1258641-38-1 97.4%
(Rac)-ABT-202 dihydrochloride
(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an nicotinic acetylcholine receptors (nAChRs) agonist and can be used as an analgesic.
T3503 MC-Val-Cit-PABC-PNP 159857-81-5 97.2%
MC-Val-Cit-PABC-PNP
MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts ...
T12165 NAChR agonist 1 1394371-75-5 97.17%
nAChR agonist 1
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
T27417L Glutathione arsenoxide hydrochloride T27417L 97.10%
Glutathione arsenoxide hydrochloride
Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) is a potentially active anti-cancer molecule and inhibitor of...
T9419 Fesoterodine 286930-02-7 97.1%
Fesoterodine
Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, re...
T3196 GNF-7 839706-07-9 97.05%
GNF-7
GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
T7392 Revefenacin 864750-70-9 96.66%
Revefenacin
Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
T27636 Ispronicline 252870-53-4 96.54%
Ispronicline
Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effect...
TQ0117 A-867744 1000279-69-5 95.66%
A-867744
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
T3865 Beta-Eudesmol 473-15-4 95.62%
beta-Eudesmol
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
T23524 W-84 dibromide 21093-51-6 95.56%
W-84 dibromide
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.
T14345 Atropine methyl bromide 2870-71-5 95.00%
Atropine methyl bromide
Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functio...
T3126 Bethanechol chloride 590-63-6 95%
Bethanechol chloride
Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to i...
T27624 Iptakalim Hydrochloride 642407-63-4 95%
Iptakalim Hydrochloride
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine rece...
T1006 Propantheline bromide 50-34-0 95%
Propantheline bromide
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle an...
T0185 Escitalopram 128196-01-0 94.62%
Escitalopram
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing e...
T8224 VU0119498 79183-37-2 100%
VU0119498
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
T8304 Anisodamine Hydrobromide 55449-49-5 100%
Anisodamine Hydrobromide
Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
ICL-CCIC-0019
T27579
ICL-CCIC-0019 is an inhibitor of choline kinase alpha (ChoKα). ICL-CCIC-0019 induces G1 arrest, endoplasmic reticulum stress, and apoptosis of cancer cell lines....
MN58b
T12085
MN58b is a selective inhibitor of choline kinase α (CHKα).
(Rac)-ABT-202 dihydrochloride
T12653
(Rac)-ABT-202 dihydrochloride is a racemate of ABT-202. ABT-202 is an nicotinic acetylcholine receptors (nAChRs) agonist and can be used as an analgesic.
MC-Val-Cit-PABC-PNP
T3503
MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts ...
nAChR agonist 1
T12165
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.
Glutathione arsenoxide hydrochloride
T27417L
Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) is a potentially active anti-cancer molecule and inhibitor of...
Fesoterodine
T9419
Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, re...
GNF-7
T3196
GNF-7 is Bcr-Abl WT and Bcr-Abl T315I inhibitor with IC50 of 133 nM and 61 nM, respectively.
Revefenacin
T7392
Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
Ispronicline
T27636
Ispronicline (TC-1734) An orally active, selective, and potent α4β2 nAChR partial agonist with antidepressant, neuroprotective, and long-lasting cognitive effect...
A-867744
TQ0117
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
beta-Eudesmol
T3865
beta-Eudesmol (Beta-Selinenol) is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a varie...
W-84 dibromide
T23524
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.
Atropine methyl bromide
T14345
Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functio...
Bethanechol chloride
T3126
Bethanechol chloride (Carbamyl-β-methylcholine chloride) is a slowly hydrolyzing muscarinic agonist with no nicotinic effects. Bethanechol is generally used to i...
Iptakalim Hydrochloride
T27624
Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine rece...
Propantheline bromide
T1006
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle an...
Escitalopram
T0185
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing e...
VU0119498
T8224
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.
Anisodamine Hydrobromide
T8304
Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.
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TargetMol