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ALK

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13138 TGFBR1-IN-1 2170830-26-7 98%
TGFBR1-IN-1
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
T61424 OD36 hydrochloride 2387510-88-3 98%
OD36 hydrochloride
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
T15262 Vactosertib Hydrochloride 1352610-25-3 98%
Vactosertib Hydrochloride
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
T10283 ALK-IN-5 2351929-66-1 98%
ALK-IN-5
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
T13781 MS4077 2230077-10-6 98%
MS4077
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
T10442 A 83-01 sodium salt 2828431-89-4 98%
A 83-01 sodium salt
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
T13421 (-)-Cevimeline hydrochloride hemihydrate T13421 98%
(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
T10426 AZ12601011 2748337-86-0 98%
AZ12601011
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
T1791L Ceritinib dihydrochloride 1380575-43-8 99.99%
Ceritinib dihydrochloride
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ...
T3061 Lorlatinib 1454846-35-5 99.93%
Lorlatinib
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1...
T2251 NVP-TAE 684 761439-42-3 99.91%
NVP-TAE 684
NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).
T1763 SB 525334 356559-20-1 99.86%
SB 525334
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
T4071 Repotrectinib 1802220-02-5 99.86%
Repotrectinib
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
T1944 LDN-214117 1627503-67-6 99.85%
LDN-214117
LDN-214117 is a potent and selective ALK2 inhibitor.
T4975 SM 16 614749-78-9 99.81%
SM 16
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
T2449 D4476 301836-43-1 99.8%
D4476
D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T35348 LDN-193189 2HCl 1435934-00-1 99.78%
LDN-193189 2HCl
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM...
T16708 R-268712 879487-87-3 99.77%
R-268712
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
T1942 DMH-1 1206711-16-1 99.7%
DMH-1
DMH-1 is a potent and selective BMP inhibitor.
T8399 Crizotinib hydrochloride 1415560-69-8 99.67%
Crizotinib hydrochloride
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
TGFBR1-IN-1
T13138
TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).
OD36 hydrochloride
T61424
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
Vactosertib Hydrochloride
T15262
Vactosertib Hydrochloride is an orally active and ATP-competitive ALK5 inhibitor (IC50: 12.9 nM). It has potently antimetastatic activity and anticancer effect. ...
ALK-IN-5
T10283
ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).
MS4077
T13781
MS4077 is an degrader of anaplastic lymphoma kinase (ALK) PROTAC(Kd of 37 nM for binding affinity to ALK).
A 83-01 sodium salt
T10442
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and...
(-)-Cevimeline hydrochloride hemihydrate
T13421
(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) is a novel muscarinic receptor agonist that is a candidate therapeutic drug for xerostomia in Sjogren's s...
AZ12601011
T10426
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively ...
Ceritinib dihydrochloride
T1791L
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ...
Lorlatinib
T3061
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1...
NVP-TAE 684
T2251
NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).
SB 525334
T1763
SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).
Repotrectinib
T4071
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respec...
LDN-214117
T1944
LDN-214117 is a potent and selective ALK2 inhibitor.
SM 16
T4975
SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).
D4476
T2449
D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
LDN-193189 2HCl
T35348
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM...
R-268712
T16708
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor ...
DMH-1
T1942
DMH-1 is a potent and selective BMP inhibitor.
Crizotinib hydrochloride
T8399
Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)
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TargetMol