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DNA Damage/DNA Repair ATM/ATR

ATM/ATR

ATM serine/threonine kinase, symbol ATM, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. It phosphorylates several key proteins that initiate activation of the DNA damage checkpoint, leading to cell cycle arrest, DNA repair or apoptosis. Several of these targets, including p53, CHK2, BRCA1, NBS1 and H2AX are tumor suppressors.Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand breaks.
Cat No. product name
T0194 Chloroquine diphosphateHOT Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T1821 CGK 733 CGK 733 is a potent and selective inhibitor of ATM/ATR.
T1958 AZ20 AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
T2084 ETP46464 ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T2235 DactolisibHOT Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
T2433 NU7026 NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR...
T2474 KU-60019HOT Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.
T2616 PIK-93 PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T2669 Berzosertib VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid...
T2685 KU55933 KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T2925 Schizandrin B Schisandrin B has an antioxidant effect on rodent liver and heart.
T3032 VE-821HOT VE-821 is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).
T3134 Mirin Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. 
T3338 AZD6738 AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
T6100 Torin 2 Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic proper...
T6261 CP-466722 CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
T6612 NU6027 NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-amino...
T6770 AZD0156 AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
T4251 GJ103 sodium salt GJ103 sodium salt is an active analog of the read-through compound GJ072.
T4443 AZ32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM i...
T5175 azd1390 AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of en...
T6283 Wortmannin Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and pot...
T10396 ATM Inhibitor-1
T10407 ATR inhibitor 2 ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-dr...
T10468 BAY-1895344 hydrochloride BAY-1895344 hydrochloride is an orally available and selective ATR inhibitor (IC50: 7 nM) with anti-tumor activity.
T15673 KU 59403 KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
T16773 Ro 90-7501 Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. Ro 90-7501 also inhibits PP5 in a...
T8660 AZ-32 AZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell)
Chloroquine diphosphate HOT
T0194CAS 50-63-5
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
CGK 733
T1821CAS 905973-89-9
CGK 733 is a potent and selective inhibitor of ATM/ATR.
AZ20
T1958CAS 1233339-22-4
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
ETP46464
T2084CAS 1345675-02-6
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
Dactolisib HOT
T2235CAS 915019-65-7
Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
NU7026
T2433CAS 154447-35-5
NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR...
KU-60019 HOT
T2474CAS 925701-49-1
Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50: 6.3 nM). It is much less effective or without effect against a panel of 229 other kinases.
PIK-93
T2616CAS 593960-11-3
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
Berzosertib
T2669CAS 1232416-25-9
VE-822 has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid...
KU55933
T2685CAS 587871-26-9
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
Schizandrin B
T2925CAS 61281-37-6
Schisandrin B has an antioxidant effect on rodent liver and heart.
VE-821 HOT
T3032CAS 1232410-49-9
VE-821 is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).
Mirin
T3134CAS 1198097-97-0
Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. 
AZD6738
T3338CAS 1352226-88-0
AZD6738 is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.
Torin 2
T6100CAS 1223001-51-1
Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic proper...
CP-466722
T6261CAS 1080622-86-1
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells.
NU6027
T6612CAS 220036-08-8
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-amino...
AZD0156
T6770CAS 1821428-35-6
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.
GJ103 sodium salt
T4251CAS 1459687-96-7
GJ103 sodium salt is an active analog of the read-through compound GJ072.
AZ32
T4443CAS T4443
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM i...
azd1390
T5175CAS 2089288-03-7
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of en...
Wortmannin
T6283CAS 19545-26-7
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and pot...
ATM Inhibitor-1
T10396CAS 2135639-94-8
ATR inhibitor 2
T10407CAS 1613191-99-3
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-dr...
BAY-1895344 hydrochloride
T10468CAS
BAY-1895344 hydrochloride is an orally available and selective ATR inhibitor (IC50: 7 nM) with anti-tumor activity.
KU 59403
T15673CAS 845932-30-1
KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).
Ro 90-7501
T16773CAS 293762-45-5
Ro 90-7501 is an amyloid β42 fibril assembly inhibitor (EC50: 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. Ro 90-7501 also inhibits PP5 in a...
AZ-32
T8660CAS T8660
AZ32 is an orally bioavailable and blood-brain barrier-penetrating inhibitor of ATM(IC50 of <6.2 nM and 0.31 μM for ATM enzyme and in cell)