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Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4496 LM22B-10 342777-54-2 98.19%
LM22B-10
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
T8427 Borussertib 1800070-77-2 98.18%
Borussertib
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)
TN1215 (2S)-2'-Methoxykurarinone 270249-38-2 98.17%
(2S)-2'-Methoxykurarinone
(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antin...
TN1490 Chrysoeriol 491-71-4 98.16%
Chrysoeriol
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
T72968 ZINC00640089 667880-11-7 98.13%
ZINC00640089
ZINC00640089 is a selective lipid carrier protein-2 (LCN2) inhibitor. ZINC00640089 inhibited cell proliferation and cell viability, and reduced AKT phosphorylati...
TN1461 (-)-Butin 492-14-8 98.07%
(-)-Butin
(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it at...
T4489 AKT-IN-1 1357158-81-6 98.02%
AKT-IN-1
AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).
T3467 Miransertib 1313881-70-7 98%
Miransertib
Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.
T5574 Guggulsterone 95975-55-6 98%
Guggulsterone
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
T6251 PF-04691502 1013101-36-4 98%
PF-04691502
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
T2420 PHT-427 1191951-57-1 98%
PHT-427
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
T5S1632 Barlerin 57420-46-9 98%
Barlerin
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
T2274 SC79 305834-79-1 98%
SC79
SC79, a selective Akt activator, may be used to enhance Akt activity in various pathological and physiological conditions.
T1961 Vistusertib 1009298-59-2 97.94%
Vistusertib
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T2974 Cyclovirobuxine D 860-79-7 97.78%
Cyclovirobuxine D
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
T1920 Capivasertib 1143532-39-1 97.59%
Capivasertib
Capivasertib (AZD5363) (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3).
TMA2474 δ-Tocotrienol 25612-59-3 97.38%
δ-Tocotrienol
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
T0392 Artemisinin 63968-64-9 97%
Artemisinin
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
T6997 SU6656 330161-87-0 97%
SU6656
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
T25150 BI-69A11 1233322-09-2 96.97%
BI-69A11
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
LM22B-10
T4496
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
Borussertib
T8427
Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt(IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt)
(2S)-2'-Methoxykurarinone
TN1215
(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antin...
Chrysoeriol
TN1490
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
ZINC00640089
T72968
ZINC00640089 is a selective lipid carrier protein-2 (LCN2) inhibitor. ZINC00640089 inhibited cell proliferation and cell viability, and reduced AKT phosphorylati...
(-)-Butin
TN1461
(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it at...
AKT-IN-1
T4489
AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).
Miransertib
T3467
Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.
Guggulsterone
T5574
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
PF-04691502
T6251
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
PHT-427
T2420
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
Barlerin
T5S1632
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
SC79
T2274
SC79, a selective Akt activator, may be used to enhance Akt activity in various pathological and physiological conditions.
Vistusertib
T1961
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
Cyclovirobuxine D
T2974
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
Capivasertib
T1920
Capivasertib (AZD5363) (AZD5363) is a new-type orally available inhibitor of the serine/threonine protein kinase AKT (IC50s: 3/7/7 nM for Akt1/2/3).
δ-Tocotrienol
TMA2474
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
Artemisinin
T0392
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
SU6656
T6997
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
BI-69A11
T25150
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
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