T2420 |
PHT-427
|
1191951-57-1
|
98%
|
|
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
|
T5S1632 |
Barlerin
|
57420-46-9
|
98%
|
|
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced inj...
|
T2274 |
SC79
|
305834-79-1
|
98%
|
|
SC79 is an AKT agonist with specificity and blood-brain barrier permeability. SC79 specifically binds to the PH domain of AKT, activates cytoplasmic AKT, and inh...
|
T1961 |
Vistusertib
|
1009298-59-2
|
97.94%
|
|
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
|
T2974 |
Cyclovirobuxine D
|
860-79-7
|
97.78%
|
|
Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
|
TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
T0392 |
Artemisinin
|
63968-64-9
|
97%
|
|
Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of mala...
|
T6997 |
SU6656
|
330161-87-0
|
97%
|
|
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.
|
T25150 |
BI-69A11
|
1233322-09-2
|
96.97%
|
|
BI-69A11 ((E)-3-(1H-Benzo[d]imidazol-2-yl)-1-(6-chloro-2-hydroxy-4-phenylquinolin-3-yl)prop-2-en-1-one) is a dual AKT and NFkB pathway inhibitor. It enhances the...
|
TN1405 |
Arnicolide D
|
34532-68-8
|
96.66%
|
|
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
|
T76795 |
Xentuzumab
|
1417158-65-6
|
95.21%
|
|
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activ...
|
T9393 |
(E)-Akt inhibitor-IV
|
959841-49-7
|
100.00%
|
|
(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.
|
T7885 |
Afuresertib hydrochloride
|
1047645-82-8
|
100%
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
|
T7879 |
TASP0415914
|
1292300-75-4
|
100%
|
|
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
|
T6065 |
Triciribine
|
35943-35-2
|
100%
|
|
Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1/2.
|
T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
T7190 |
Actein
|
18642-44-9
|
|
|
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
|
T7315 |
BAY1125976
|
1402608-02-9
|
|
|
BAY1125976 is an allosteric inhibitor of Akt1 and Akt2 (IC50s of 5.2 and 18 nM, respectively, in a time-resolved FRET assay)
|
T3399 |
Psoralidin
|
18642-23-4
|
|
|
Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive p...
|
T14072 |
A-443654
|
552325-16-3
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|