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Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T39899 Hu7691 2360523-76-6 99.86%
Hu7691
Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces diffe...
T35528 TD52 1798328-24-1 99.5%
TD52
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
T36848 Combretastatin A-1 109971-63-3 97.49%
Combretastatin A-1
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated in...
TN1033 Sennidin A 641-12-3 100%
Sennidin A
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
TN1034 Sennidin B 517-44-2
Sennidin B
Sennidin B stimulates glucose incorporation in rat adipocytes.
TN2694 2,3-Dihydro-3-methoxywithaferin A 21902-96-5 98%
2,3-Dihydro-3-methoxywithaferin A
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
TN3404 Altholactone 65408-91-5 98%
Altholactone
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN4932 Sageone 142546-15-4 98%
Sageone
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
T20232 Kazinol B 99624-27-8 98%
Kazinol B
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
TN1269 3β-Methoxy-2,3-dihydrowithaferin A 73365-94-3 98%
3β-Methoxy-2,3-dihydrowithaferin A
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
T78913 AKT-IN-18 98%
AKT-IN-18
AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity. It promotes apoptosis and is suitable for u...
T79214 Tubulin/AKT1-IN-1 98%
Tubulin/AKT1-IN-1
Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and met...
T79364 Antiangiogenic agent 4 98%
Antiangiogenic agent 4
Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].
T79560 22-(4′-py)-JA 1178895-15-2 98%
22-(4′-py)-JA
22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting ...
T79701 PI3K-IN-48 98%
PI3K-IN-48
PI3K-IN-48, a PI3K inhibitor, exhibits an IC50 of 1.55 ± 0.18 μM in A549 cells, demonstrating its potency in this context. It induces G0/G1 phase arrest and cell...
T79722 2-Chlorophenoxazine 56821-03-5 98%
2-Chlorophenoxazine
2-Chlorophenoxazine is an Akt inhibitor that demonstrates an in vitro inhibitory concentration (IC50) of 2-5 μM and has the capacity to induce apoptosis. It is u...
T80653 Larixol 1438-66-0 98%
Larixol
Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for ...
T81041 TAS0612 2148902-58-1 98%
TAS0612
TAS0612, a novel oral inhibitor of RSK, AKT, and S6K, exhibits broad-spectrum antitumor activity by impeding cell growth [1].
T81784 MK-2206 free base 1032349-93-1 98%
MK-2206 free base
MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1, Ak...
T14925 Cenisertib 871357-89-0 98%
Cenisertib
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
Hu7691
T39899
Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces diffe...
TD52
T35528
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
Combretastatin A-1
T36848
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated in...
Sennidin A
TN1033
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
Sennidin B
TN1034
Sennidin B stimulates glucose incorporation in rat adipocytes.
2,3-Dihydro-3-methoxywithaferin A
TN2694
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Sageone
TN4932
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
Kazinol B
T20232
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
3β-Methoxy-2,3-dihydrowithaferin A
TN1269
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
AKT-IN-18
T78913
AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity. It promotes apoptosis and is suitable for u...
Tubulin/AKT1-IN-1
T79214
Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and met...
Antiangiogenic agent 4
T79364
Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].
22-(4′-py)-JA
T79560
22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting ...
PI3K-IN-48
T79701
PI3K-IN-48, a PI3K inhibitor, exhibits an IC50 of 1.55 ± 0.18 μM in A549 cells, demonstrating its potency in this context. It induces G0/G1 phase arrest and cell...
2-Chlorophenoxazine
T79722
2-Chlorophenoxazine is an Akt inhibitor that demonstrates an in vitro inhibitory concentration (IC50) of 2-5 μM and has the capacity to induce apoptosis. It is u...
Larixol
T80653
Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for ...
TAS0612
T81041
TAS0612, a novel oral inhibitor of RSK, AKT, and S6K, exhibits broad-spectrum antitumor activity by impeding cell growth [1].
MK-2206 free base
T81784
MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1, Ak...
Cenisertib
T14925
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
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TargetMol