T39899 |
Hu7691
|
2360523-76-6
|
99.86%
|
|
Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces diffe...
|
T35528 |
TD52
|
1798328-24-1
|
99.5%
|
|
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 bindin...
|
T36848 |
Combretastatin A-1
|
109971-63-3
|
97.49%
|
|
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated in...
|
TN1033 |
Sennidin A
|
641-12-3
|
100%
|
|
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
|
TN1034 |
Sennidin B
|
517-44-2
|
|
|
Sennidin B stimulates glucose incorporation in rat adipocytes.
|
TN2694 |
2,3-Dihydro-3-methoxywithaferin A
|
21902-96-5
|
98%
|
|
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
|
TN3404 |
Altholactone
|
65408-91-5
|
98%
|
|
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
|
TN4932 |
Sageone
|
142546-15-4
|
98%
|
|
Sageone represents a promising anticancer agent against gastric cancer that warrants further study, it synergizes with cisplatin cytotoxicity in SNU-1 human gast...
|
T20232 |
Kazinol B
|
99624-27-8
|
98%
|
|
Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity by activati...
|
TN1269 |
3β-Methoxy-2,3-dihydrowithaferin A
|
73365-94-3
|
98%
|
|
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
|
T78913 |
AKT-IN-18
|
|
98%
|
|
AKT-IN-18, an Akt inhibitor, demonstrates an IC50 value of 69.45 μM in A549 cells, effectively impeding Akt activity. It promotes apoptosis and is suitable for u...
|
T79214 |
Tubulin/AKT1-IN-1
|
|
98%
|
|
Tubulin/AKT1-IN-1 (Compound D1-1) serves as an inhibitor of both tubulin polymerization and AKT pathway activation, effectively suppressing proliferation and met...
|
T79364 |
Antiangiogenic agent 4
|
|
98%
|
|
Compound 3b, an antiangiogenic agent, inhibits Akt phosphorylation in both HFF and HUVEC cells and is utilized in cancer research [1].
|
T79560 |
22-(4′-py)-JA
|
1178895-15-2
|
98%
|
|
22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting ...
|
T79701 |
PI3K-IN-48
|
|
98%
|
|
PI3K-IN-48, a PI3K inhibitor, exhibits an IC50 of 1.55 ± 0.18 μM in A549 cells, demonstrating its potency in this context. It induces G0/G1 phase arrest and cell...
|
T79722 |
2-Chlorophenoxazine
|
56821-03-5
|
98%
|
|
2-Chlorophenoxazine is an Akt inhibitor that demonstrates an in vitro inhibitory concentration (IC50) of 2-5 μM and has the capacity to induce apoptosis. It is u...
|
T80653 |
Larixol
|
1438-66-0
|
98%
|
|
Larixol acts as both an fMLP inhibitor and a modulator of various signaling pathways by inhibiting Src kinase, ERK1/2, p38, and AKT phosphorylation critical for ...
|
T81041 |
TAS0612
|
2148902-58-1
|
98%
|
|
TAS0612, a novel oral inhibitor of RSK, AKT, and S6K, exhibits broad-spectrum antitumor activity by impeding cell growth [1].
|
T81784 |
MK-2206 free base
|
1032349-93-1
|
98%
|
|
MK-2206 free base is an allosteric Akt inhibitor that is both potent and selective, administered orally, exhibiting IC50 values of 8, 12, and 65 nM for Akt1, Ak...
|
T14925 |
Cenisertib
|
871357-89-0
|
98%
|
|
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
|