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Endocrinology/Hormones Androgen Receptor

Androgen Receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
Cat No. Product Name
T0135 Estradiol valerate β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.
T0272 Nilutamide Nilutamide, an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for ...
T0380 Bicalutamide Bicalutamide, a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor bin...
T0476 Abbolactone Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
T0489 Flutamide Flutamide is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
T0856 Dehydroepiandrosterone acetate Dehydroepiandrosterone acetate is a primary C19 steroid generated by the adrenal cortex.
T0856L Dehydroepiandrosterone Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although th...
T1167 Cyproterone acetate Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosteron...
T1480 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary o...
T1541 Drospirenone Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
T1596 Chlormadinone acetate Chlormadinone acetate is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
T2108 Andarine Andarine (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).
T2195 Epiandrosterone Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
T2207 Adrenosterone Adrenosterone is a steroid hormone isolated from the adrenal cortex.
T2236 RU58841 RU 58841 is a specific androgen receptor antagonist or anti-androgen; RU 58841 has a significant effect on hair regrowth.
T2339 Apalutamide Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
T2408 Ostarine Ostarine is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promo...
T2991 3,3'-Diindolylmethane DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
T3017 Trenbolone acetate Trenbolone acetate is a synthetic androgen steroid with anabolic properties.
T3137 Parenabol Boldenone undecylenate is a synthetic steroid.
T3357 17 alpha-propionate 17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
T3618 GSK-2881078 GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting t...
T6002 EnzalutamideHOT Enzalutamide (MDV 3100) is a non-steroidal androgen receptor (AR) antagonist (IC50: 36 nM in LNCaP prostate cells).
T6400 AZD3514 AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
T6509 Galeterone Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhib...
T6889 MI-136 MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
T6915 Darolutamide ODM-201 is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
T4358 Testolone RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
T7040 Angiotensin II human Angiotensin II is mediated by AT1 and AT2 receptors. AT1 and AT2 receptors have seven transmembrane glycoproteins with 30% sequence similarity.Angiotensin I con...
T4357 LGD-3303 LGD-3303 is an androgen receptor modulator, with good oral bioavailability.
T7358 YK11 YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when us...
T7440 4,4'-DDE 4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T7690 2-hydroxy Flutamide 2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
TQ0209 Ailanthone Ailanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 30...
TQ0214 Dimethylcurcumin Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and in...
T8217 Enzalutamide carboxylic acid Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
TN1061 Ganoderol B Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in pros...
TN1370 Allura Red AC Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
TN2245 Sunset yellow Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care mus...
TN1067 6'-O-Galloyl paeoniflorin 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
TN1150 Procyanidin B3 Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
TN1663 Ganoderic acid DM Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
TN2252 Syrosingopine Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase i...
T19449 N-desmethyl Enzalutamide D6 N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.
T19450 N-desmethyl Enzalutamide N-desmethyl Enzalutamide is the active Enzalutamide metabolite.
T10946 D4-abiraterone D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abi...
T14675 BMS-564929 BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
T14843 Bifluranol Bifluranol is an anti-androgen.
T15749 LGD-2226 LGD-2226 displays tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 is a selective and orally active androgen r...
T15816 LY341495 LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).
Estradiol valerate
T0135CAS 979-32-8
β-estradiol 17-valerate (EV) is a synthetic estrogen. In hormone replacement therapy drugs, it is widely used in combination with other steroid hormones.
Nilutamide
T0272CAS 63612-50-0
Nilutamide, an antineoplastic hormonal agent, is mainly used in the treatment of prostate Y. Nilutamide is a pure, nonsteroidal anti-androgen with affinity for ...
Bicalutamide
T0380CAS 90357-06-5
Bicalutamide, a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor bin...
Abbolactone
T0476CAS 52-01-7
Spironolactone is an Aldosterone Antagonist. The mechanism of action of spironolactone is as an Aldosterone Antagonist.
Flutamide
T0489CAS 13311-84-7
Flutamide is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
Dehydroepiandrosterone acetate
T0856CAS 853-23-6
Dehydroepiandrosterone acetate is a primary C19 steroid generated by the adrenal cortex.
Dehydroepiandrosterone
T0856LCAS 53-43-0
Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although th...
Cyproterone acetate
T1167CAS 427-51-0
Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosteron...
Danazol
T1480CAS 17230-88-5
Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary o...
Drospirenone
T1541CAS 67392-87-4
Drospirenone is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.
Chlormadinone acetate
T1596CAS 302-22-7
Chlormadinone acetate is an orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
Andarine
T2108CAS 401900-40-1
Andarine (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).
Epiandrosterone
T2195CAS 481-29-8
Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property.
Adrenosterone
T2207CAS 382-45-6
Adrenosterone is a steroid hormone isolated from the adrenal cortex.
RU58841
T2236CAS 154992-24-2
RU 58841 is a specific androgen receptor antagonist or anti-androgen; RU 58841 has a significant effect on hair regrowth.
Apalutamide
T2339CAS 956104-40-8
Apalutamide is a small molecule and androgen receptor (AR) antagonist with potential antineoplastic activity.
Ostarine
T2408CAS 841205-47-8
Ostarine is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promo...
3,3'-Diindolylmethane
T2991CAS 1968-05-4
DIM (3,3'-diindolylmethane), a small molecule compound, is a proposed Y preventive agent.
Trenbolone acetate
T3017CAS 10161-34-9
Trenbolone acetate is a synthetic androgen steroid with anabolic properties.
Parenabol
T3137CAS 13103-34-9
Boldenone undecylenate is a synthetic steroid.
17 alpha-propionate
T3357CAS 19608-29-8
17 alpha-propionate is a new topical and peripherally selective androgen antagonist.
GSK-2881078
T3618CAS 1539314-06-1
GSK2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting t...
Enzalutamide HOT
T6002CAS 915087-33-1
Enzalutamide (MDV 3100) is a non-steroidal androgen receptor (AR) antagonist (IC50: 36 nM in LNCaP prostate cells).
AZD3514
T6400CAS 1240299-33-5
AZD3514 is a potent and oral androgen receptor downregulator with Ki of 2.2 μM and has ability of reducing AR protein expression.Phase 1.
Galeterone
T6509CAS 851983-85-2
Galeterone is an orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhib...
MI-136
T6889CAS 1628316-74-4
MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.
Darolutamide
T6915CAS 1297538-32-9
ODM-201 is an androgen receptor (AR) antagonist that blocks AR nuclear translocation (Ki: 11 nM).
Testolone
T4358CAS 1182367-47-0
RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
Angiotensin II human
T7040CAS 4474-91-3
Angiotensin II is mediated by AT1 and AT2 receptors. AT1 and AT2 receptors have seven transmembrane glycoproteins with 30% sequence similarity.Angiotensin I con...
LGD-3303
T4357CAS 917891-35-1
LGD-3303 is an androgen receptor modulator, with good oral bioavailability.
YK11
T7358CAS 1370003-76-1
YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when us...
4,4'-DDE
T7440CAS 72-55-9
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
2-hydroxy Flutamide
T7690CAS 52806-53-8
2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer
Ailanthone
TQ0209CAS 981-15-7
Ailanthone is an effective inhibitor of both full-length androgen receptor (AR) (IC50: 69 nM) and constitutively active truncated AR splice variants (IC50: 30...
Dimethylcurcumin
TQ0214CAS 52328-98-0
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and in...
Enzalutamide carboxylic acid
T8217CAS 1242137-15-0
Enzalutamide carboxylic acid is an antagonist of androgen receptor (AR) .
Ganoderol B
TN1061CAS 104700-96-1
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in pros...
Allura Red AC
TN1370CAS 25956-17-6
Allura Red AC and amaranth are very important food azo dyes used in food, drug, paper, cosmetic and textile industries.
Sunset yellow
TN2245CAS 2783-94-0
Sunset yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products, they can have cytotoxic and genotoxic potential, it care mus...
6'-O-Galloyl paeoniflorin
TN1067CAS 122965-41-7
6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
Procyanidin B3
TN1150CAS 23567-23-9
Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.
Ganoderic acid DM
TN1663CAS 173075-45-1
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
Syrosingopine
TN2252CAS 84-36-6
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase i...
N-desmethyl Enzalutamide D6
T19449CAS
N-desmethyl Enzalutamide D6 is a deuterium labeled N-desmethyl Enzalutamide.
N-desmethyl Enzalutamide
T19450CAS 1242137-16-1
N-desmethyl Enzalutamide is the active Enzalutamide metabolite.
D4-abiraterone
T10946CAS 154229-21-7
D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abi...
BMS-564929
T14675CAS 627530-84-1
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
Bifluranol
T14843CAS 34633-34-6
Bifluranol is an anti-androgen.
LGD-2226
T15749CAS 328947-93-9
LGD-2226 displays tissue selectivity in animal models, with reduced effects on prostate compared to muscle. LGD-2226 is a selective and orally active androgen r...
LY341495
T15816CAS 201943-63-7
LY341495 is an antagonist of metabotropic glutamate receptor (IC50s: 2.9 nM, 10 nM, 170 nM for mGluR-2, mGluR-3, mGluR-8, respectively).