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Androgen Receptor

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor that is activated by binding any of the androgenic hormones, including testosterone and dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T39044 Rezvilutamide 1572045-62-5 99.97%
Rezvilutamide
Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.Rezvilutamide (SHR3680...
TN1663 Ganoderic acid DM 173075-45-1 98%
Ganoderic acid DM
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
T78810 BWA-522 98%
BWA-522
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) an...
T78811 PROTAC AR-NTD degrader 1 98%
PROTAC AR-NTD degrader 1
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain...
T78945 WCA-814 98%
WCA-814
WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in prost...
T79024 Androgen receptor-IN-5 1391944-16-3 98%
Androgen receptor-IN-5
Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties. It additionally suppresses the synthesis of IL-17A, IL-17F, and...
T79156 (R)-SKBG-1 98%
(R)-SKBG-1
(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA, ...
T79465 Anticancer agent 135 98%
Anticancer agent 135
Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 het...
T79519 YXG-158 2952994-34-0 98%
YXG-158
YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1....
T79725 ARD-1676 2632305-36-1 98%
ARD-1676
ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activit...
T79891 Androgen receptor degrader-3 2753650-84-7 98%
Androgen receptor degrader-3
Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential applica...
T80633 Androgen receptor degrader-1 2616553-35-4 98%
Androgen receptor degrader-1
Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].
T80647 Androgen receptor degrader-2 2616553-33-2 98%
Androgen receptor degrader-2
Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].
T81662 N-Nitrosodicyclohexylamine 947-92-2 98%
N-Nitrosodicyclohexylamine
N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition ...
T83119 Androgen receptor antagonist 9 915086-32-7 98%
Androgen receptor antagonist 9
Androgen receptor antagonist 9 (compound 28) is an antagonist of the androgen receptor [1].
TN1061 Ganoderol B 104700-96-1 98%
Ganoderol B
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate ...
T15749 LGD-2226 328947-93-9 98%
LGD-2226
LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle...
T10946 D4-abiraterone 154229-21-7 98%
D4-abiraterone
D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abira...
TN4774 Physalin A 23027-91-0 98%
Physalin A
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T14675 BMS-564929 627530-84-1 98%
BMS-564929
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
Rezvilutamide
T39044
Rezvilutamide (SHR3680) is an orally available androgen receptor inhibitor that crosses the blood-brain barrier and has antitumor activity.Rezvilutamide (SHR3680...
Ganoderic acid DM
TN1663
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
BWA-522
T78810
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) an...
PROTAC AR-NTD degrader 1
T78811
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain...
WCA-814
T78945
WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in prost...
Androgen receptor-IN-5
T79024
Androgen receptor-IN-5 is a potent inhibitor of the androgen receptor with anticancer properties. It additionally suppresses the synthesis of IL-17A, IL-17F, and...
(R)-SKBG-1
T79156
(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA, ...
Anticancer agent 135
T79465
Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 het...
YXG-158
T79519
YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1....
ARD-1676
T79725
ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activit...
Androgen receptor degrader-3
T79891
Androgen Receptor Degrader-3 (ARD-3) is a compound that inhibits androgen receptor signaling and promotes the degradation of the receptor, with potential applica...
Androgen receptor degrader-1
T80633
Androgen Receptor Degrader-1 (Compound 18) is a potent agent for androgen receptor degradation, applicable in cancer research [1].
Androgen receptor degrader-2
T80647
Androgen Receptor Degrader-2 (Compound 9) is a potent degrader of androgen receptors, with potential application in cancer research [1].
N-Nitrosodicyclohexylamine
T81662
N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition ...
Androgen receptor antagonist 9
T83119
Androgen receptor antagonist 9 (compound 28) is an antagonist of the androgen receptor [1].
Ganoderol B
TN1061
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate ...
LGD-2226
T15749
LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle...
D4-abiraterone
T10946
D4-Abiraterone is an inhibitor of CYP17A1, 3b-hydroxysteroid dehydrogenase (3βHSD) and steroid 5a-reductase (SRD5A), the main metabolite of abiraterone. D4-Abira...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
BMS-564929
T14675
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
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TargetMol