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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7656 | Apelin-13 | ||
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 ... | |||
T10843 | CMF019 | Apelin receptor | |
CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse). | |||
T14390L | (2R,3S)-Azelaprag | Apelin receptor | |
(2R,3S)-N-(4-(2,6-dimethoxyphenyl)-5-(5-methylpyridin-3-yl)-4H-1,2,4-triazol-3-yl)-3-(5-methylpyrimidin-2-yl)butane-2-sulfonamide is an Apelin receptor agonist with an EC50 for Apelin receptors of 0.012 µM.(2R,3S)-N-(4-(... | |||
T7847 | Apelin-13 triTFA(217082-58-1(free base)) | Others | |
Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM. | |||
TP1260 | [Pyr1]-Apelin-13 | [pGlu1]-Apelin-13 | Apelin receptor |
[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist. | |||
T39823L | Apelin-12 acetate | Apelin-12 acetate (229961-08-4 Free base) | Apelin receptor , p38 MAPK , JNK |
Apelin-12 acetate possesses a high affinity to orphan receptor APJ receptor. Apelin-12 acetate inhibits the JNK and p38 MAPK signaling pathway of the apoptosis-related MAPKs family, thus offering protection to neurons. | |||
TP2092L | Apelin-17 (human, bovine) acetate | Apelin-17 (human, bovine) acetate(217082-57-0 free base) | HIV Protease |
Apelin-17 (human, bovine) acetate is an endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94). | |||
T14390 | Azelaprag | AMG 986 | Apelin receptor |
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases. | |||
TP1922L1 | ELA-11 (human) acetate(1784687-32-6 free base) | Apelin receptor , Arrestin | |
ELA-11 (human) acetate high affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. | |||
T10346 | Apelin agonist 1 | Others | |
Apelin agonist 1 is an oral selective apelin agonist AM-2995, an agonist of the APJ (APLNR, angiotensin receptor like-1) receptor. It may be used in the treatment of cardiovascular conditions. | |||
T63669 | APJ receptor agonist 6 | ||
APJ receptor agonist 6 is a potent agonist of the APJ (apelin receptor) (Ki: 0.059 μM). (EC50: 6.22 μM). | |||
T75785 | Apelin-17(human, bovine) TFA | ||
Apelin-17(human, bovine) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-17(human, bovine) TFA binds to human APJ receptors expressed in HEK 293 cells ( pIC 50 =9.02). Apelin-17(human, bovine) ... | |||
T61330 | ML233 | ||
ML233 is a potent non-peptide apelin receptor agonist (EC50 = 3.7 μM) that exhibits more than 21-fold selectivity over the closely related angiotensin 1 receptor (AT1) (>79 μM) [1]. | |||
TP2001 | MM 54 | ||
Potent apelin receptor antagonist (Ki = 82 nM; IC50 = 93 nM). Antagonizes the inhibitory affect of [Pyr1]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. Recuces tumor expansion and lengthens surviv... | |||
T75783 | Apelin-36(human) TFA | ||
Apelin-36(human) TFA is an endogenous orphan G protein-coupled receptor APJ agonist, with an EC 50 of 20 nM. Apelin-36(human) TFA shows high affinity to human APJ receptors expressed in HEK 293 cells (pIC5 50 =8.61). Ape... | |||
TP2092 | Apelin-17(human, bovine) | Apelin-17 (human, bovine) | |
Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94). | |||
T39823 | Apelin-12 | ||
Apelin-12 is a highly potent C-terminal fragment of a polypeptide that exhibits a strong affinity towards the orphan receptor APJ. It plays a role in maintaining body fluid balance and regulating feeding control in the c... | |||
T75784 | Apelin-36(rat, mouse) TFA | ||
Apelin-36(rat, mouse) TFA is an endogenous orphan G protein-coupled receptor APJ agonist. Apelin-36(rat, mouse) TFA binds to APJ receptors with an IC 50 of 5.4 nM, and potently inhibits cAMP production with an EC 50 of 0... | |||
T64305 | APJ receptor agonist 7 | ||
APJ receptor agonist 7 (compound 37) is an orally active APJ (apelin receptor) agonist (Ki: 0.059 μM). arrestin (EC50: 0.063 μM). | |||
TP2096 | ELA-21 (human) | ||
High affinity apelin receptor agonist. Binds apelin receptors in left ventricle from normal and pulmonary arterial hypertensive (PAH) hearts (pKi values are 9.31 and 9.46, respectively). Bioactive fragment of ELA-32. Inh... | |||
TP1424 | Apelin-13 TFA (217082-58-1 free base) | Apelin-13 TFA | |
Apelin-13 is an endogenous ligand of APJ receptor, and the EC 50 value of activated G protein coupled receptor is 0.37 nM. | |||
T63153 | APJ receptor agonist 5 | ||
APJ receptor agonist 5 (compound 3) is a potent and orally active apelin receptor (APJ) agonist (EC 50:0.4 nM). APJ receptor agonist 5 has excellent pharmacokinetic profiles in rodent models of heart failure (HF) and an ... | |||
TP1922 | ELA-11(human) | ELA-11 (human) | |
High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32. Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro. | |||
TP1923 | Elabela(19-32) | ELA-14 (human) | |
Potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32. Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo. | |||
T39813 | APJ receptor agonist 1 | ||
APJ receptor agonist 1, a potent biphenyl acid derivative, acts as an agonist (EC50 of 0.093 nM and 0.12 nM for human and rat APJ receptors, respectively) for the APJ receptor (APJ-R). It exhibits significant in vitro po... | |||
T39587 | APJ receptor agonist 4 | ||
APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor ( APJ ) with EC 50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rod... | |||
T76044 | Elabela(19-32) TFA | ||
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ) . Elabela(19-32) TFA activates the G αi1 and β-arrestin-2 signaling pathways with EC 50 s of 8.6 nM and 166 nM. Elabela(19-32)... | |||
T76053 | ELA-11(human) TFA | ||
ELA-11(human) TFA is a high affinity apelin receptor agonist (K i =14 nM). ELA-11(human) TFA is a bioactive fragment of ELA-32. ELA-11(human) TFA inhibits forskolin-induced cAMP production and stimulates β-arrestin recru... | |||
TP2097 | ELA-32(human) | ELA-32 (human) | |
Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein ... | |||
T76052 | ELA-32(human) TFA | ||
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist (IC 50 =0.27 nM; K d =0.51 nM). ELA-32(human) TFA exhibits no binding GPR15 and GPR25. ELA-32(human) TFA activates the PI3K/AKT pathway and promotes se... |