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Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79711 Antitumor photosensitizer-4 98%
Antitumor photosensitizer-4
Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. This photo...
T79758 BQZ-485 1906915-49-8 98%
BQZ-485
BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction. This disruption impedes vesicular transport from the endopl...
T79783 NSC 48160 6640-90-0 98%
NSC 48160
NSC 48160, a chemical compound, exhibits inhibitory effects on pancreatic cancer cell proliferation, with half-maximal inhibitory concentrations (IC50s) of 84.3 ...
T79791 Immunosuppressant-1 1224571-03-2 98%
Immunosuppressant-1
Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, incl...
T79878 Hydroxy-PP-Me 833481-77-9 98%
Hydroxy-PP-Me
Hydroxy-PP-Me is a potent and specific CBR1 inhibitor, exhibiting an IC50 of 759 nM. It not only inhibits serum-withdrawal-induced apoptosis but also enhances As...
T79941 Antimycin A2c 98%
Antimycin A2c
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation...
T79971 Asparanin A 84633-33-0 98%
Asparanin A
Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways. It ...
T79982 2'-epi-2'-O-Acetylthevetin B 82145-55-9 98%
2'-epi-2'-O-Acetylthevetin B
2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L. seeds, diminishes cell viability, triggers apoptosis, and disrupt...
T79983 Flaccidoside II 140694-19-5 98%
Flaccidoside II
Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve Sh...
T79998 Celosin K 1950579-53-9 98%
Celosin K
Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury. It mitigates oxidative stress, prevents apoptosis...
T80221 TAT-BH4 (Bcl-xL) 98%
TAT-BH4 (Bcl-xL)
TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an N-terminal eosin-labeled cysteine and the pr...
T80222 TAT-BH4 (Bcl-xL) (TFA) 98%
TAT-BH4 (Bcl-xL) (TFA)
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-termina...
T80418 TAT-NEP1-40 98%
TAT-NEP1-40
TAT-NEP1-40, a blood-brain barrier (BBB) permeable peptide, confers protection to PC12 cells against oxygen and glucose deprivation (OGD) while promoting neurite...
T80419 TAT-NEP1-40 TFA 98%
TAT-NEP1-40 TFA
TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth. Addit...
T80420 TAT-NEP1-40 acetate 98%
TAT-NEP1-40 acetate
TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose deprivati...
T81102 ST1074 1402703-29-0 98%
ST1074
ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].
T82672 Cpm-1285 300349-97-7 98%
cpm-1285
CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists. It exhibits a high binding affinity fo...
T82793 Caerin 1.1 TFA 98%
Caerin 1.1 TFA
Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells an...
T78586L Ac-IETD-CHO TFA 98%
Ac-IETD-CHO TFA
Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-medi...
TN5280 (-)-Zeylenol 78804-17-8 98%
(-)-Zeylenol
(-)-Zeylenol (Zeylenol) is a natural product derived from the stems of the Uvaria grandiflora, showing anti-inflammatory, antifeedant and antitumor biological ac...
Antitumor photosensitizer-4
T79711
Antitumor Photosensitizer-4 (compound 10b), a conjugate of dasatinib and imatinib, serves as a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. This photo...
BQZ-485
T79758
BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction. This disruption impedes vesicular transport from the endopl...
NSC 48160
T79783
NSC 48160, a chemical compound, exhibits inhibitory effects on pancreatic cancer cell proliferation, with half-maximal inhibitory concentrations (IC50s) of 84.3 ...
Immunosuppressant-1
T79791
Immunosuppressant-1 (Compound 31) suppresses T-cell proliferation triggered by anti-CD3/anti-CD28 co-stimulation and demonstrates immunosuppressive effects, incl...
Hydroxy-PP-Me
T79878
Hydroxy-PP-Me is a potent and specific CBR1 inhibitor, exhibiting an IC50 of 759 nM. It not only inhibits serum-withdrawal-induced apoptosis but also enhances As...
Antimycin A2c
T79941
Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation...
Asparanin A
T79971
Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways. It ...
2'-epi-2'-O-Acetylthevetin B
T79982
2'-Epi-2'-O-Acetylthevetin B (GHSC-74), a cardiac glycoside extractable from Cerbera manghas L. seeds, diminishes cell viability, triggers apoptosis, and disrupt...
Flaccidoside II
T79983
Flaccidoside II, an active triterpenoid saponin from Anemone flaccida rhizome, both inhibits proliferation and induces apoptosis in Malignant Peripheral Nerve Sh...
Celosin K
T79998
Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury. It mitigates oxidative stress, prevents apoptosis...
TAT-BH4 (Bcl-xL)
T80221
TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an N-terminal eosin-labeled cysteine and the pr...
TAT-BH4 (Bcl-xL) (TFA)
T80222
"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-termina...
TAT-NEP1-40
T80418
TAT-NEP1-40, a blood-brain barrier (BBB) permeable peptide, confers protection to PC12 cells against oxygen and glucose deprivation (OGD) while promoting neurite...
TAT-NEP1-40 TFA
T80419
TAT-NEP1-40 TFA, a blood-brain barrier-permeable peptide, safeguards PC12 cells against oxygen and glucose deprivation (OGD) and fosters neurite outgrowth. Addit...
TAT-NEP1-40 acetate
T80420
TAT-NEP1-40 acetate, a potential therapeutic for axonal regeneration and functional recovery post-stroke, safeguards PC12 cells from oxygen and glucose deprivati...
ST1074
T81102
ST1074, a dual inhibitor of CerS2 and CerS4, promotes apoptosis and is applicable in cancer research [1].
cpm-1285
T82672
CPM-1285 induces apoptosis by effectively inhibiting the function of intracellular Bcl-2 and associated death antagonists. It exhibits a high binding affinity fo...
Caerin 1.1 TFA
T82793
Caerin 1.1 TFA, a host defense peptide derived from the Australian tree frog Litoria's glandular secretions, exhibits anti-proliferative effects on HeLa cells an...
Ac-IETD-CHO TFA
T78586L
Ac-IETD-CHO TFA is a granzyme B and caspase-8 inhibitor that inhibits caspase8 activity by blocking caspase3 precursor cleavage.Ac-IETD-CHO TFA inhibits Fas-medi...
(-)-Zeylenol
TN5280
(-)-Zeylenol (Zeylenol) is a natural product derived from the stems of the Uvaria grandiflora, showing anti-inflammatory, antifeedant and antitumor biological ac...
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