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Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T20158 Phenformin 114-86-3 98%
Phenformin
Phenformin (BRN 1977317) is a biguanide compound with anticancer and anti-glycemic activity, inhibits skin tumor growth and promotes keratinocyte differentiation...
T72789 Telomerase-IN-4 2892295-10-0 98%
Telomerase-IN-4
Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1].
T72790 Telomerase-IN-5 2892295-16-6 98%
Telomerase-IN-5
Telomerase-IN-5 is a potent inhibitor of telomerase with antiproliferative properties, and it induces apoptosis [1].
T72989 HGGPPS-IN-3 2763223-96-5 98%
hGGPPS-IN-3
Compound 13h (hGGPPS-IN-3) is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS), characterized as a C-2-substituted thienopyrimidine-bas...
T73299 APE1-IN-2 2923433-95-6 98%
APE1-IN-2
APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiti...
T74768 Antitumor agent-92 2922842-01-9 98%
Antitumor agent-92
Antitumor Agent-92, an Icaritin derivative, induces G0/G1 phase cell cycle arrest and promotes apoptosis. This compound shows promise for hepatocellular carcinom...
T74940 Anticancer agent 81 2820286-56-2 98%
Anticancer agent 81
Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the anti...
T75678 Tomentosin 33649-15-9 98%
Tomentosin
Tomentosin, a sesquiterpene lactone extracted from Caspian sea raspberry, has potential anti-inflammatory and anticancer activities, promoting apoptosis and inhi...
T8282 (S)-(−)-Perillyl alcohol 18457-55-1 98%
(S)-(−)-Perillyl alcohol
(S)-(−)-Perillyl alcohol (Perillyl alcohol) , a monoterpene found in lavender, inhibits the farnesylation of Ras, upregulates the mannose-6-phosphate receptor an...
TN3417 Angophorol 133442-54-3 98%
Angophorol
Angophorol is a flavonoid compound from the culm fern, Pterocarpus indicus, in the family Pterocarpaceae.Angophorol exerts potential anticancer activity through ...
T4S1499 Ginsenoside Rk1 494753-69-4 98%
Ginsenoside Rk1
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
TN5486 Pinobanksin 3-(2-methyl)butyrate 1221923-43-8 98%
Pinobanksin 3-(2-methyl)butyrate
Pinobanksin 3-(2-methyl)butyrate is a Pinobanksin derivative. pinobanksin is a apoptosis inducer that can induce apoptosis of F6 cells.
T35982 Capsorubin 470-38-2 98%
Capsorubin
Capsorubin is a carotenoid with a variety of biological activities. capsorubin inhibited lipid peroxidation induced by 2,2′-azino(2,4-dimethylvaleronitrile) (AMV...
T6346 WYE-132 1144068-46-1 98%
WYE-132
WYE-125132 (WYE-132 (WYE-125132)) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related...
T35617 Mitoguazone 459-86-9 98%
Mitoguazone
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis...
T19934 Dehydrocrenatidine 65236-62-6 98%
Dehydrocrenatidine
Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
T10177 (5Z,2E)-CU-3 1815598-71-0 98%
(5Z,2E)-CU-3
(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM....
T15378 Gemcitabine elaidate 210829-30-4 98%
Gemcitabine elaidate
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with ...
T6804 Chetomin 1403-36-7 98%
Chetomin
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrati...
TN1086 Dehydrotrametenolic acid 6879-05-6 98%
Dehydrotrametenolic acid
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
Phenformin
T20158
Phenformin (BRN 1977317) is a biguanide compound with anticancer and anti-glycemic activity, inhibits skin tumor growth and promotes keratinocyte differentiation...
Telomerase-IN-4
T72789
Telomerase-IN-4 is a potent inhibitor of telomerase with antiproliferative properties and induces apoptosis [1].
Telomerase-IN-5
T72790
Telomerase-IN-5 is a potent inhibitor of telomerase with antiproliferative properties, and it induces apoptosis [1].
hGGPPS-IN-3
T72989
Compound 13h (hGGPPS-IN-3) is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS), characterized as a C-2-substituted thienopyrimidine-bas...
APE1-IN-2
T73299
APE1-IN-2 (compound AP1), a Pt(IV) proagent, selectively targets the essential base excision repair protein apurinic/apyrimidinic endonuclease 1 (APE1). Exhibiti...
Antitumor agent-92
T74768
Antitumor Agent-92, an Icaritin derivative, induces G0/G1 phase cell cycle arrest and promotes apoptosis. This compound shows promise for hepatocellular carcinom...
Anticancer agent 81
T74940
Anticancer agent 81 (Compound 37b3) induces tumor cell cycle arrest and apoptosis and serves as a payload for conjugation with Trastuzumab, resulting in the anti...
Tomentosin
T75678
Tomentosin, a sesquiterpene lactone extracted from Caspian sea raspberry, has potential anti-inflammatory and anticancer activities, promoting apoptosis and inhi...
(S)-(−)-Perillyl alcohol
T8282
(S)-(−)-Perillyl alcohol (Perillyl alcohol) , a monoterpene found in lavender, inhibits the farnesylation of Ras, upregulates the mannose-6-phosphate receptor an...
Angophorol
TN3417
Angophorol is a flavonoid compound from the culm fern, Pterocarpus indicus, in the family Pterocarpaceae.Angophorol exerts potential anticancer activity through ...
Ginsenoside Rk1
T4S1499
Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures. Ginsenoside Rk1 has an anti-inflammatory effect, suppresses the acti...
Pinobanksin 3-(2-methyl)butyrate
TN5486
Pinobanksin 3-(2-methyl)butyrate is a Pinobanksin derivative. pinobanksin is a apoptosis inducer that can induce apoptosis of F6 cells.
Capsorubin
T35982
Capsorubin is a carotenoid with a variety of biological activities. capsorubin inhibited lipid peroxidation induced by 2,2′-azino(2,4-dimethylvaleronitrile) (AMV...
WYE-132
T6346
WYE-125132 (WYE-132 (WYE-125132)) is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related...
Mitoguazone
T35617
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis...
Dehydrocrenatidine
T19934
Dehydrocrenatidine (Kumujian G) is an inhibitor of JAK and induces cell apoptosis.
(5Z,2E)-CU-3
T10177
(5Z,2E)-CU-3 is a potent and selective inhibitor of DGKα isozyme with an IC50 value of 0.6 μM and inhibition of DGKα by competing ATP with a Km value of 0.48 mM....
Gemcitabine elaidate
T15378
Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with ...
Chetomin
T6804
Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrati...
Dehydrotrametenolic acid
TN1086
Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in ...
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TargetMol