Apoptosis

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay.

Cat. No.	Product name	CAS No.	Purity
T4327	Prexasertib dihydrochloride	1234015-54-3	97.5%
T4327	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2...
T35329L	EAD1 TFA(1644388-26-0 Free base)	2320427-95-8	97.49%
T35329L	EAD1 HCL is a potent autophagy inhibitor with antiproliferative activity in lung and pancreatic cancer cells. EAD1 HCL also induces apoptosis
T10761	Ceranib-2	1402830-75-4	97.49%
T10761	Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decr...
T8956	BC-1258	1507370-40-2	97.48%
T8956	BC-1258 is a unique small molecule F-box/LRR-repeat protein 2 (FBXL2) activator.
T2160	Suramin Sodium Salt	129-46-4	97.47%
T2160	Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
T9102	WM-3835	2229025-70-9	97.47%
T9102	WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
T2649	Menin-MLL inhibitor MI-2	1271738-62-5	97.46%
T2649	Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
T3375	Verbascoside	61276-17-3	97.46%
T3375	Verbascoside (Kusaginin) is a protein kinase C inhibitor with antimicrobial, anti-inflammatory activities.
T12085	MN58b	203192-01-2	97.46%
T12085	MN58b is a selective inhibitor of choline kinase α (CHKα).
TN1839	Kumatakenin	3301-49-3	97.44%
TN1839	Kumatakenin can suppress >80% of the SOS-inducing activity of Trp-P-1 at <0.06 micromol/mL.
T16791	Rottlerin	82-08-6	97.41%
T16791	Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKC...
T8380	Bendamustine	16506-27-7	97.38%
T8380	Bendamustine (SDX105) for the treatment of Non-Hodgkin Lymphomas and Chronic Lymphocytic Leukemia
T2392	Nafamostat mesylate	82956-11-4	97.36%
T2392	Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and...
T16750	Rigosertib	592542-59-1	97.33%
T16750	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer a...
T6525	GW 5074	220904-83-6	97.3%
T6525	GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, ...
T6787	BIO-acetoxime	667463-85-6	97.28%
T6787	BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
T12932L	SM-164	957135-43-2	97.25%
T12932L	SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP.
T2300	AZD1208	1204144-28-4	97.24%
T2300	AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.
T3572	NSC 15364	4550-72-5	97.22%
T3572	NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.
T3S1416	Decursin	5928-25-6	97.22%
T3S1416	1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepat...