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Cat No. | Product Name | Synonyms | Targets |
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T7202 | ITE | AhR , Aryl Hydrocarbon Receptor | |
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity. | |||
T21966 | MeBIO | GSK-3 , Aryl Hydrocarbon Receptor , CDK | |
MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β. | |||
T1960 | YL-109 | AhR , Aryl Hydrocarbon Receptor | |
YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo. | |||
T20625 | Prochloraz | Sporgon,Prelude | Estrogen Receptor/ERR , AhR , Androgen Receptor , Antifungal |
Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and and... | |||
T4608 | PDM2 | AhR , Aryl Hydrocarbon Receptor | |
PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. | |||
T15410 | GNF351 | Aryl Hydrocarbon Receptor | |
GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes wit... | |||
T2448 | CH-223191 | CH 223191 | AhR , Aryl Hydrocarbon Receptor |
CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR). | |||
T5622 | BAY-218 | AHR antagonist 1 | AhR , Aryl Hydrocarbon Receptor |
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line. | |||
T4607 | CAY 10465 | CAY10465,CAY10465 Exclusive | AhR , Aryl Hydrocarbon Receptor |
CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM). | |||
T10270 | BAY 2416964 | Aryl Hydrocarbon Receptor | |
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 192, IC50: 341 nM). It has the potential for cancer treatment. | |||
T10007 | 1,4-Chrysenequinone | Chrysene-1,4-dione | AhR |
1,4-Chrysenequinone (Chrysene-1,4-dione) is an activator of aryl hydrocarbon receptor (AhR). | |||
TQ0257 | FICZ | 6-Formylindolo[3,2-b]carbazole | Aryl Hydrocarbon Receptor |
FICZ (6-Formylindolo[3,2-b]carbazole) is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM). | |||
T1831 | StemRegenin 1 | SR1 | AhR , Aryl Hydrocarbon Receptor |
StemRegenin 1 (SR1) is an aryl hydrocarbon receptor (AhR) inhibitor. | |||
T21704 | 5-fluoro 203 | 5F-203,NSC-703786 | Others |
5-fluoro 203 (NSC-703786) is a cytotoxic molecule leading to cell death by forming DNA adducts. 5-fluoro 203 induces aryl hydrocarbon receptor signaling, and elevates expression of CYP1A1. 5-fluoro 203 treatment of cells... | |||
T13276 | VAF347 | Aryl Hydrocarbon Receptor | |
VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects. | |||
T2623 | PD98059 | PD 98059 | ERK , Aryl Hydrocarbon Receptor , MEK , Autophagy |
PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive. PD98059 is also antagonistic as a ligand for AHR. PD98059 inhibits autophagy. | |||
T2148 | Carbidopa monohydrate | Carbidopa Hydrate,S(-)-Carbidopa | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine. | |||
T4644 | Tapinarof | GSK2894512,Benvitimod,WBI 1001 | AhR , Aryl Hydrocarbon Receptor |
Tapinarof (Benvitimod) is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease. | |||
T0640 | Benzyl butyl phthalate | BBP,1,2-benzenedicarboxylic acid,butyl phenylmethyl ester,Butyl benzyl phthalate | Others , Aryl Hydrocarbon Receptor |
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC. | |||
T2707 | Pifithrin-α hydrobromide | Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide | Ferroptosis , Aryl Hydrocarbon Receptor , p53 |
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) is a p53 inhibitor, inhibiting p53-dependent transactivation of p53-responsive genes. | |||
T8980 | SGA360 | Aryl Hydrocarbon Receptor | |
SGA360 is a selective aryl hydrocarbon (Ah) receptor modulator. It exhibits anti-inflammatory properties. | |||
T10269 | AHR antagonist 2 | Aryl Hydrocarbon Receptor | |
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively. | |||
T5541 | PDM11 | 1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth,PDM 11 | AhR |
PDM11 (1-[2-(4-Chloro-phenyl)-vinyl]-3,5-diMeth) is an antagonist of aryl hydrocarbon receptor (AhR) | |||
T10325 | ANI-7 | Chk | |
ANI-7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI-7 inhibits the growth of multiple cancer cells and potently and selectively inhibits the growth of MCF-7 breast cancer cells (GI50: 0.56 μM). | |||
T10526 | β-NF-JQ1 | Others | |
β-NF-JQ1 is a PROTAC that recruits aryl hydrocarbon receptor E3 (AhR E3) ligase to target proteins. β-NF-JQ1 uses β-NF as an AhR ligand to target bromodomain (BRD)-containing proteins and induce AhR and BRD protein inter... | |||
T3637 | Pifithrin-β hydrobromide | Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide) | Ferroptosis , p53 |
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorder... | |||
T24960 | 10-Cl-BBQ | 10ClBBQ | |
10-Cl-BBQ is a ligand of aryl hydrocarbon receptor (AhR). | |||
T25235 | CHD-5 | CHD5 | |
CHD-5 is a selective antagonist of the aryl hydrocarbon receptor (AhR). | |||
T16082 | Mivotilate | YH439 | Others |
Mivotilate, a potent, non-toxic aryl hydrocarbon receptor (AhR) activator, functions as a hepatoprotective agent. | |||
T23686 | AHR-activator-1023 | Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023 | |
AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator. | |||
T10271 | AHR antagonist 4 | Others | |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T20307 | Benzyl 2-naphthyl ether | AI3 00945,AI300945,AI3-00945 | |
Benzyl 2-naphthyl ether causes the activation of the aryl hydrocarbon receptor. | |||
T22528 | 6,2',4'-Trimethoxyflavone | Others | |
The compound is an Aryl hydrocarbon receptor antagonist (EC50 = 0.9 μM). It also has no short term agonist activity and no species or promoter dependence. | |||
T22725 | DiMNF | Others | |
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment. | |||
T23400 | StemRegenin 1 (hydrochloride) | StemRegenin 1 (hydrochloride) (1227633-49-9 free base) | Others |
StemRegenin 1 is an aryl hydrocarbon receptor signaling antagonist (IC50: 127 nM in CD34+ cells). | |||
T10272 | AHR antagonist 5 | Others | |
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. | |||
T10258 | AFP464 free base | NSC710464 free base | HIF |
AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator. | |||
T71938 | MNF | ||
MNF, also known as 3,4-MNF, is an antagonist of the aryl hydrocarbon receptor (AhR). MNF reduces UVR-mediated immunosuppression and induces Tregs in murine contact hypersensitivity (CHS). | |||
T70257 | Avitriptan HCl | ||
Avitriptan, also known as BMS-180048, is a selective 5-HT1-like receptor agonist. Avitriptan is an effective compound for the treatment of migraine headaches with a prolonged duration of response. Avitriptan Is a Ligan... | |||
T10273 | AhR modulator-1 | Others | |
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrog... | |||
T72430 | L-Kynurenine sulfate | ||
L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist, activates AHR-driven polarization of naive T cells towards the anti-inflammatory Treg phenotype. | |||
T61244 | AhR agonist 2 | ||
AhR agonist 2 (Compound 12a) is a highly potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 0.03 nM. This compound rapidly induces nuclear enrichment of AhR and initiates transcription of ... | |||
T60539 | KG-548 | ||
KG-548 is an ARNT/TACC3 disruptor as well as a HIF-1α inhibitor. KG-548 directly interferes with the formation of the ARNT/TACC3 complex by competitively binding the ARNT PAS-B domain with TACC3. ARNT is the aryl hydroca... | |||
T63389 | AHR antagonist 5 hemimaleate | ||
AHR antagonist 5 hemimaleate is a potent antagonist (IC50 < 0.5 μM) of the orally active aryl hydrocarbon receptor (AHR). aHR antagonist 5 hemimaleate in combination with the detection site inhibitor anti-PD-1 exhibited ... | |||
T79436 | AHR agonist 4 | Aryl Hydrocarbon Receptor | |
AHR agonist 4 (compound 24e), as an Aryl hydrocarbon receptor (AHR) agonist, modulates the immune equilibrium between Th17/22 and Treg cells. It is a lead compound under investigation for anti-psoriasis drugs and demonst... | |||
T79283 | HCYP1B1-IN-1 | ||
hCYP1B1-IN-1 (compound B18) is an inhibitor of hCYP1B1 with an IC50 value of 3.6 nM and also acts as an antagonist of the Aryl Hydrocarbon Receptor. This compound demonstrates favorable metabolic stability and good cell ... | |||
T78716 | MKA031 | ||
MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impe... | |||
T72056 | KYN-101 | ||
KYN-101 is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-medi... | |||
T83826 | 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin | 1,2,3,6,7,8-HxCDD,PCDD 67 | |
1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin, a polychlorinated dibenzodioxin (PCDD), acts as an agonist for the aryl hydrocarbon receptor (AhR; EC50s = 5.4 and 9.3 nM at 4 and 8 h, respectively, in a reporter assay). It has b... | |||
T70313 | Indoxyl Sulfate-d5 potassium salt | ||
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of in... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1451 | Brevifolincarboxylic acid | AhR , Aryl Hydrocarbon Receptor , Glucosidase | |
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 3... | |||
T6795 | Carbidopa | (S)-(-)-Carbidopa,Lodosyn | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. | |||
T4928 | L-Kynurenine | (S)-Kynurenine | AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite |
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ... | |||
T0878 | Diosmin | Venosmine,Diosmil,Barosmin | Aryl Hydrocarbon Receptor , Norepinephrine |
Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls. | |||
TN2883 | 3',4'-Dimethoxyflavone | Others , PARP | |
3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities. | |||
T4939 | Indole-3-pyruvic acid | 3-(3-Indolyl)-2-oxopropanoic acid | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta... | |||
T5281 | Skatole | Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole | AhR , p38 MAPK , Aryl Hydrocarbon Receptor , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal |
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. | |||
T2947 | Indole-3-carbinol | I3C,3-Indolemethanol,Indole-3-Methanol | E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53 |
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation. | |||
T4938 | Potassium 1H-indol-3-yl sulfate | Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate | AhR , Endogenous Metabolite |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm... | |||
TN6366 | Lupinalbin A | ||
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine... | |||
T75433 | Norisoboldine hydrochloride | ||
Norisoboldine hydrochloride, an orally active aryl hydrocarbon receptor (AhR) agonist and a prominent isoquinoline alkaloid found in Radix Linderae, is utilized for research purposes in the study of Rheumatoid Arthritis ... | |||
T73402 | Flavipin | ||
Flavipin, an aryl hydrocarbon receptor (Ahr) agonist, activates Ahr downstream gene expression in mouse CD4+ T cells and CD11b+ macrophages. This compound disrupts the stabilizing effect of Arid5a on the newly identified... |
Cat No. | Product Name | Species | Expression System |
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TMPY-01709 | HIF-1 alpha Protein, Human, Recombinant (His) | Human | E. coli |
HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. It is one of the two subunits of Hypoxia-inducible factor-1 (... |