Aryl Hydrocarbon Receptor

The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, or dioxin receptor) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a transcription factor that regulates gene expression. It was originally thought to function primarily as a sensor of xenobiotic chemicals and also as the regulator of enzymes such as cytochrome P450s that metabolize these chemicals. The most notable of these xenobiotic chemicals are aromatic (aryl) hydrocarbons from which the receptor derives its name. More recently, it has been discovered that AhR is activated (or deactivated) by a number of endogenous indole derivatives such as kynurenine. In addition to regulating metabolism enzymes, the AhR has roles in regulating immunity, stem cell maintenance, and cellular differentiation.

Cat. No.	Product name	CAS No.	Purity
T10269	AHR antagonist 2	2338747-54-7	98%
T10269	AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.
T39762	AHR antagonist 5 free base	2247950-42-9	98%
T39762	AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.
TQ0257	FICZ	172922-91-7	98%
TQ0257	FICZ is a potent aryl agonist for the hydrocarbon receptor (AhR, Kd: 70 pM).
T13276	VAF347	574759-62-9	98%
T13276	VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
T4607	CAY 10465	688348-33-6	100%
T4607	CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).
T4644	Tapinarof	79338-84-4	100%
T4644	Tapinarof is targeted as a topical cream treatment for psoriasis, a chronic autoimmune skin disease.
T0878	Diosmin	520-27-4	94.41%
T0878	Diosmin is a bioflavonoid that strengthens vascular walls.
T2947	Indole-3-carbinol	700-06-1	97.06%
T2947	Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
T7202	ITE	448906-42-1	98%
T7202	ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity.
T5622	BAY-218	2162982-11-6	98%
T5622	AHR antagonist 1 is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.
T6795	Carbidopa	28860-95-9	98.01%
T6795	Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.
T4928	L-Kynurenine	2922-83-0	98.44%
T4928	L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppress...
T21966	MeBIO	667463-95-8	98.84%
T21966	MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
T15410	GNF351	1227634-69-6	99.04%
T15410	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal to...
T2148	Carbidopa monohydrate	38821-49-7	99.29%
T2148	Carbidopa Hydrate is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
TN1451	Brevifolincarboxylic acid	18490-95-4	99.42%
TN1451	Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarb...
T4608	PDM2	688348-25-6	99.57%
T4608	PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
T2448	CH-223191	301326-22-7	99.58%
T2448	CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).
T2623	PD98059	167869-21-8	99.66%
T2623	PD98059 is a non-ATP competitive MEK inhibitor (IC50: 2/50 μM for MEK1/MEK2).
T5281	Skatole	83-34-1	99.74%
T5281	Skatole is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.