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Search Results for " aurora-kinase "

Targets

83

Compounds

3

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T5524 Aurora kinase inhibitor-3 Aurora Kinase Inhibitor III Aurora Kinase
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
T9040 Aurora kinase inhibitor-2 IUN-70219,Aurora Kinase Inhibitor II Aurora Kinase
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).
T1825 Reversine Aurora Kinase , Adenosine Receptor , Autophagy
Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).
T6767 TCS7010 Aurora A Inhibitor I Apoptosis , Aurora Kinase
TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B.
T6532 Hesperadin Influenza Virus , Parasite , Aurora Kinase , Autophagy
Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo.
T21981 Phthalazinone pyrazole Aurora Kinase
Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.
T10215 AAPK-25 Apoptosis , PLK , Aurora Kinase
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ...
T6785 BI-847325 Apoptosis , MEK , Aurora Kinase
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.
T6126 JNJ-7706621 JNJ 7706621 Apoptosis , CDK , Aurora Kinase
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.
T16359 NU6140 CDK , Aurora Kinase
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e...
T6315 MLN8054 Casein Kinase , PKA , Src , Aurora Kinase
MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.
T8866 GW779439X Apoptosis , Antibacterial , CDK , Aurora Kinase
GW779439X is an inhibitor of CDK.
T2611 CCT 137690 CCT137690 Apoptosis , Aurora Kinase
CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).
T63773 Aurora kinase inhibitor-8
Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.
T62789 Aurora kinase inhibitor-9
Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B bipolar kinase inhibitor, acting on Aurora A (IC50: 0.093 μM), Aurora B (IC50: 0.09 μM). broad-spectrum anti-proliferative activity.
T72522 Aurora kinase-IN-1
Aurora kinase-IN-1 is a potent inhibitor of aurora kinase . Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-...
T1886 TAK-632 Raf , FGFR , PDGFR , Aurora Kinase
TAK-632 is a potent pan-Raf inhibitor.
T2471 MK-8745 Apoptosis , Aurora Kinase
MK-8745 is a potent and selective Aurora A inhibitor.
T2709 TAK-901 TAK901 JAK , CDK , Src , Aurora Kinase
TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others.
T6077 ZM-447439 Apoptosis , MEK , Src , Aurora Kinase
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect aga...
T6338 PHA-680632 PHA 680632,PHA680632 FGFR , PLK , Aurora Kinase
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
T63853 Aurora kinase inhibitor-10
Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.
T6458 CYC-116 VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ...
T17267 XL228 IGF-1R , Bcr-Abl , Src , Aurora Kinase
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
T60783 Aurora/LIM kinase-IN-1
Aurora/LIM kinase-IN-1 (Compound F114) is a potent aurora and lim kinase dual inhibitor. Aurora/LIM kinase-IN-1 inhibits the proliferation and invasion of GBM that may be used in drug development efforts for GBM, further...
T4428 CCT241736 FLT , Aurora Kinase
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica...
T2094 Danusertib PHA-739358 FGFR , Trk receptor , c-RET , Bcr-Abl , Aurora Kinase , Autophagy
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in ...
T41256 SP-96 Aurora Kinase
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negati...
T64338 AKI603 AKI 603,AKI-603 Aurora Kinase
AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l...
T6129 GSK-1070916 GSK-1070916A,GSK1070916 Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase
GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.
T6380 AMG 900 AMG900,AMG-900 p38 MAPK , Tyrosine Kinases , Aurora Kinase
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
T2341 KW-2449 KW2449 Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T3068 AT9283 J-504568 Apoptosis , FLT , JAK , Bcr-Abl , Aurora Kinase , Autophagy
AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).
T14371 Barasertib AZD1152 Apoptosis , Aurora Kinase
AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
T6068 MK-5108 VX-689,MK5108 Aurora Kinase , Autophagy
MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.
T2509 Tozasertib MK-0457,VX 680 Aurora Kinase , Autophagy
Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases.
T35570 Chiauranib CS2164 c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...
T2358 ENMD-2076 Apoptosis , VEGFR , FGFR , FLT , c-RET , PDGFR , Src , Aurora Kinase
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
TQ0059 Ilorasertib ABT-348 VEGFR , FLT , c-RET , PDGFR , Aurora Kinase
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ...
T2617 SNS-314 Mesylate SNS-314 Aurora Kinase
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.
T6435 CCT129202 Aurora Kinase
CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively. It is less potent to FGFR3, GSK3β, PDGFRβ, etc.
T6028 PF 477736 PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T2241 Alisertib MLN 8237 Apoptosis , Aurora Kinase , Autophagy
Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.
T6936 PF-03814735 FAK , VEGFR , FLT , Trk receptor , Aurora Kinase
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
T12864 SCH-1473759 hydrochloride Aurora Kinase
SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).
T2602 Barasertib-HQPA 1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA|AZD2811 Apoptosis , Aurora Kinase
Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.
T8537 Tripolin A Aurora Kinase
Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)
T23426 TC-A 2317 hydrochloride Others , Aurora Kinase
TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.
T29170 XU1 Benzo[c][1,8]naphthyridin-6(5h)-One Aurora Kinase
XU1(Benzo[c][1,8]naphthyridin-6(5h)-One) is an Aurora protein kinase inhibitor used for the treatment of diseases suitable for inhibition, regulation or modulation of kinase signaling.
T50110 CD532 Aurora Kinase
CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational tran...

Compounds

Aurora kinase inhibitor-3
T5524
Synonym: Aurora Kinase Inhibitor III
Target: Aurora Kinase
Aurora kinase inhibitor-2
T9040
Synonym: IUN-70219,Aurora Kinase Inhibitor II
Target: Aurora Kinase
Reversine
T1825
Synonym:
Target: Aurora Kinase, Adenosine Receptor, Autophagy
TCS7010
T6767
Synonym: Aurora A Inhibitor I
Target: Apoptosis, Aurora Kinase
Hesperadin
T6532
Synonym:
Target: Influenza Virus, Parasite, Aurora Kinase, Autophagy
Phthalazinone pyrazole
T21981
Synonym:
Target: Aurora Kinase
AAPK-25
T10215
Synonym:
Target: Apoptosis, PLK, Aurora Kinase
BI-847325
T6785
Synonym:
Target: Apoptosis, MEK, Aurora Kinase
JNJ-7706621
T6126
Synonym: JNJ 7706621
Target: Apoptosis, CDK, Aurora Kinase
NU6140
T16359
Synonym:
Target: CDK, Aurora Kinase
MLN8054
T6315
Synonym:
Target: Casein Kinase, PKA, Src, Aurora Kinase
GW779439X
T8866
Synonym:
Target: Apoptosis, Antibacterial, CDK, Aurora Kinase
CCT 137690
T2611
Synonym: CCT137690
Target: Apoptosis, Aurora Kinase
Aurora kinase inhibitor-8
T63773
Synonym:
Target:
Aurora kinase inhibitor-9
T62789
Synonym:
Target:
Aurora kinase-IN-1
T72522
Synonym:
Target:
TAK-632
T1886
Synonym:
Target: Raf, FGFR, PDGFR, Aurora Kinase
MK-8745
T2471
Synonym:
Target: Apoptosis, Aurora Kinase
TAK-901
T2709
Synonym: TAK901
Target: JAK, CDK, Src, Aurora Kinase
ZM-447439
T6077
Synonym:
Target: Apoptosis, MEK, Src, Aurora Kinase
PHA-680632
T6338
Synonym: PHA 680632,PHA680632
Target: FGFR, PLK, Aurora Kinase
Aurora kinase inhibitor-10
T63853
Synonym:
Target:
CYC-116
T6458
Synonym:
Target: VEGFR, FLT, CDK, S6 Kinase, Aurora Kinase
XL228
T17267
Synonym:
Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase
Aurora/LIM kinase-IN-1
T60783
Synonym:
Target:
CCT241736
T4428
Synonym:
Target: FLT, Aurora Kinase
Danusertib
T2094
Synonym: PHA-739358
Target: FGFR, Trk receptor, c-RET, Bcr-Abl, Aurora Kinase, Autophagy
SP-96
T41256
Synonym:
Target: Aurora Kinase
AKI603
T64338
Synonym: AKI 603,AKI-603
Target: Aurora Kinase
GSK-1070916
T6129
Synonym: GSK-1070916A,GSK1070916
Target: Apoptosis, Tie-2, FLT, AMPK, Aurora Kinase
AMG 900
T6380
Synonym: AMG900,AMG-900
Target: p38 MAPK, Tyrosine Kinases, Aurora Kinase
KW-2449
T2341
Synonym: KW2449
Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase
AT9283
T3068
Synonym: J-504568
Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy
Barasertib
T14371
Synonym: AZD1152
Target: Apoptosis, Aurora Kinase
MK-5108
T6068
Synonym: VX-689,MK5108
Target: Aurora Kinase, Autophagy
Tozasertib
T2509
Synonym: MK-0457,VX 680
Target: Aurora Kinase, Autophagy
Chiauranib
T35570
Synonym: CS2164
Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase
ENMD-2076
T2358
Synonym:
Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase
Ilorasertib
TQ0059
Synonym: ABT-348
Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase
SNS-314 Mesylate
T2617
Synonym: SNS-314
Target: Aurora Kinase
CCT129202
T6435
Synonym:
Target: Aurora Kinase
PF 477736
T6028
Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736
Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase
Alisertib
T2241
Synonym: MLN 8237
Target: Apoptosis, Aurora Kinase, Autophagy
PF-03814735
T6936
Synonym:
Target: FAK, VEGFR, FLT, Trk receptor, Aurora Kinase
SCH-1473759 hydrochloride
T12864
Synonym:
Target: Aurora Kinase
Barasertib-HQPA
T2602
Synonym: 1H-Pyrazole-3-acetamide,Barasertib,AZD1152-HQPA,AZD2811,AZD1152-HQPA|AZD2811
Target: Apoptosis, Aurora Kinase
Tripolin A
T8537
Synonym:
Target: Aurora Kinase
TC-A 2317 hydrochloride
T23426
Synonym:
Target: Others, Aurora Kinase
XU1
T29170
Synonym: Benzo[c][1,8]naphthyridin-6(5h)-One
Target: Aurora Kinase
CD532
T50110
Synonym:
Target: Aurora Kinase
1 2
Cat No. Product Name Synonyms Targets
T2718 Palmatine chloride Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T5S0802 Palmatine Berbericinine,Burasaine Indoleamine 2,3-Dioxygenase (IDO) , AChR , AChE , Aurora Kinase
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery,...
TN3834 Derrone Antifection
Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. It is also a novel Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 t...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04467 NME1 Protein, Human, Recombinant (His) Human E. coli
NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the inter...
TargetMol