Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T3685	SR9009	1379686-30-2	99.8%
T3685	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-E...
T0461	Berberine chloride	633-65-8	99.8%
T0461	Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to ...
T1802	ZLN005	49671-76-3	99.8%
T1802	ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.
T2494	Cilengitide	188968-51-6	99.8%
T2494	Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
T4S1102	Liensinine diperchlorate	5088-90-4	99.8%
T4S1102	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome...
T1637	Deferoxamine Mesylate	138-14-7	99.8%
T1637	Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
T0147	Clemastine fumarate	14976-57-9	99.8%
T0147	Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.
T11741	KAN0438757	1451255-59-6	99.8%
T11741	KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.
T11844	LG-100064	153559-46-7	99.79%
T11844	LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)
T6646	Rosiglitazone hydrochloride	302543-62-0	99.79%
T6646	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.
T2S2362	Dehydrocorydaline nitrate	13005-09-9	99.79%
T2S2362	1. Dehydrocorydaline(DHC) not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions, and the inhibitory effect ...
T3354	BIA 10-2474	1233855-46-3	99.79%
T3354	BIA 10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central ne...
T2921	Sinomenine hydrochloride	6080-33-7	99.79%
T2921	Sinomenine hydrochloride (Kukoline hydrochloride) is extracted from Sinomenium Acutum Rehderett Wilson.
T7886	Nidufexor	1773489-72-7	99.79%
T7886	Nidufexor is an agonist for the farnesoid X receptor (FXR).
T3952	TPEN	16858-02-9	99.79%
T3952	TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.
T72039	CLK1-IN-3	2922550-28-3	99.79%
T72039	Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly e...
T2527	Ulipristal acetate	126784-99-4	99.79%
T2527	Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity....
T0097	MRT67307	1190378-57-4	99.79%
T0097	Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-lik...
T19857	Glyphosate	1071-83-6	99.79%
T19857	Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.
T7586	Trifarotene	895542-09-3	99.78%
T7586	Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC...