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Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T3952 TPEN 16858-02-9 99.79%
TPEN
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.
T72039 CLK1-IN-3 2922550-28-3 99.79%
CLK1-IN-3
Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly e...
T2527 Ulipristal acetate 126784-99-4 99.79%
Ulipristal acetate
Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity....
T0097 MRT67307 1190378-57-4 99.79%
MRT67307
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-lik...
T19857 Glyphosate 1071-83-6 99.79%
Glyphosate
Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.
T7586 Trifarotene 895542-09-3 99.78%
trifarotene
Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC...
T0209 Loperamide hydrochloride 34552-83-5 99.78%
Loperamide hydrochloride
Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
T6858 Hydroxyprogesterone caproate 630-56-8 99.78%
Hydroxyprogesterone caproate
Hydroxyprogesterone caproate (Delalutin) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system...
T2338 JZL195 1210004-12-8 99.78%
JZL195
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
T6340 Enalaprilat Dihydrate 84680-54-6 99.78%
Enalaprilat Dihydrate
Enalaprilat Dihydrate (MK-422 Dihydrate) (IC50=1.94 nM) is a potent angiotensin-converting enzyme (ACE) inhibitor.
T15806 LY2562175 1103500-20-4 99.78%
LY2562175
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
T2500 Cediranib 288383-20-0 99.78%
Cediranib
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (I...
T2993 Cordycepin 73-03-0 99.78%
Cordycepin
Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic ac...
T1076 Dexamethasone 50-02-2 99.77%
Dexamethasone
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
T8055 TFEB activator 1 39777-61-2 99.77%
TFEB activator 1
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's dise...
T2143 Bergapten 484-20-8 99.77%
Bergapten
Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
T7530 PD146176 4079-26-9 99.77%
PD146176
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses...
T8526 Metformin 657-24-9 99.77%
Metformin
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensit...
T1662 5-Aminolevulinic acid hydrochloride 5451-09-2 99.77%
5-Aminolevulinic acid hydrochloride
5-Aminolevulinic acid hydrochloride (5-ALA) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
T2170 SKF-96365 hydrochloride 130495-35-1 99.76%
SKF-96365 hydrochloride
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells...
TPEN
T3952
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.
CLK1-IN-3
T72039
Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly e...
Ulipristal acetate
T2527
Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity....
MRT67307
T0097
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-lik...
Glyphosate
T19857
Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.
trifarotene
T7586
Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC...
Loperamide hydrochloride
T0209
Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
Hydroxyprogesterone caproate
T6858
Hydroxyprogesterone caproate (Delalutin) is a synthetic progestational agent. It binds to and activates nuclear progesterone receptors in the reproductive system...
JZL195
T2338
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
Enalaprilat Dihydrate
T6340
Enalaprilat Dihydrate (MK-422 Dihydrate) (IC50=1.94 nM) is a potent angiotensin-converting enzyme (ACE) inhibitor.
LY2562175
T15806
LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).
Cediranib
T2500
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (I...
Cordycepin
T2993
Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic ac...
Dexamethasone
T1076
Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activit...
TFEB activator 1
T8055
TFEB activator 1 (Curcumin analog compound C1) is an activator of transcription factor EB (TFEB) with promise for the prevention or treatment of Alzheimer's dise...
Bergapten
T2143
Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
PD146176
T7530
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses...
Metformin
T8526
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensit...
5-Aminolevulinic acid hydrochloride
T1662
5-Aminolevulinic acid hydrochloride (5-ALA) is an intermediate in heme biosynthesis in the body and the universal precursor of tetrapyrroles.
SKF-96365 hydrochloride
T2170
SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells...
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TargetMol