Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T4519	Alisol A	19885-10-0	99.81%
T4519	Alisol A (Alisol-A) may be an autophagic inducer, it has anti-cancer activity, it presents inhibitory effects on cancer cell lines tested(HepG2, MDA-MB-231, and ...
T0026	Sulfalene	152-47-6	99.81%
T0026	Sulfalene (SMP2), a long-acting sulfonamide antibiotic, is used for the therapy of chronic bronchitis, urinary tract infections, and malaria.
T1549	Raloxifene hydrochloride	82640-04-8	99.81%
T1549	Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopau...
TN2225	Soyasapogenol B	595-15-3	99.81%
TN2225	Soyasapogenol B has anti-cancer, hypocholesterolemic, anticomplementary, hepatoprotective effects, it inhibits proliferation of cultured Hep-G2.
T1426	Pyrazinamide	98-96-4	99.81%
T1426	Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide deri...
T6202	DAPT	208255-80-5	99.81%
T6202	DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces ...
T6976	SB 239063	193551-21-2	99.81%
T6976	SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
T2240	GSK2578215A	1285515-21-0	99.81%
T2240	GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
T0740	Metformin hydrochloride	1115-70-4	99.81%
T0740	Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the...
T8808L	LYN-1604 dihydrochloride	2310109-38-5	99.80%
T8808L	LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
T2685	KU-55933	587871-26-9	99.80%
T2685	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T2449	D4476	301836-43-1	99.8%
T2449	D4476 (Casein Kinase I Inhibitor) is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T2933	Wogonin	632-85-9	99.8%
T2933	Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
T3685	SR9009	1379686-30-2	99.8%
T3685	SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-E...
T0461	Berberine chloride	633-65-8	99.8%
T0461	Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to ...
T1802	ZLN005	49671-76-3	99.8%
T1802	ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α.
T2494	Cilengitide	188968-51-6	99.8%
T2494	Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
T1676	Rosuvastatin	287714-41-4	99.8%
T1676	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the...
T1637	Deferoxamine Mesylate	138-14-7	99.8%
T1637	Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulat...
T0147	Clemastine fumarate	14976-57-9	99.8%
T0147	Clemastine fumarate (Meclastine (fumarate)) is a synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties.