Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T1660	Silibinin	22888-70-6	99.76%
T1660	Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consis...
T3861	Isobavachalcone	20784-50-3	99.76%
T3861	Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in ...
T0680	Lamotrigine	84057-84-1	99.76%
T0680	Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer. The physiologic effect of lamotrigine is by means of Decreased Central Nervous System Disorg...
T6283	Wortmannin	19545-26-7	99.76%
T6283	Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that bl...
T6130	Skepinone-L	1221485-83-1	99.76%
T6130	Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.
T3695	Pepstatin	26305-03-3	99.76%
T3695	Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin...
T63343	ULK1-IN-2	2497409-01-3	99.76%
T63343	ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against canc...
T5S1097	Neferine	2292-16-2	99.75%
T5S1097	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Nefer...
T1927	CCT007093	176957-55-4	99.75%
T1927	CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).
T1825	Reversine	656820-32-5	99.75%
T1825	Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).
T7679	UBCS039	358721-70-7	99.75%
T7679	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T2210	Genipin	6902-77-8	99.74%
T2210	Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.
T5858	Sertindole	106516-24-9	99.74%
T5858	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kd...
T6699	Tempol	2226-96-2	99.74%
T6699	Tempol (Tanol) is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
T0131	Cepharanthine	481-49-2	99.74%
T0131	Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and ...
T1102	Mifepristone	84371-65-3	99.74%
T1102	Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
T5281	Skatole	83-34-1	99.74%
T5281	Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon r...
T2372	Ponatinib	943319-70-8	99.74%
T2372	Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively)...
T6081	Milciclib	802539-81-7	99.73%
T6081	Milciclib (PHA-848125) (PHA-848125) is a potent, ATP-competitive CDK inhibitor for CDK2 with IC50 of 45 nM. It is >3-fold more selective for CDK2 than CDK1, 2, 4...
T1621	Imatinib Mesylate	220127-57-1	99.73%
T1621	Imatinib Mesylate (STI-571) is a tyrosine kinase receptor inhibitor with antineoplastic activity (IC50s: 0.6 μM, 0.1 μM and 0.1 μM for v-Abl, c-Kit and PDGFR, re...