Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T4085	Paris saponin VII	68124-04-9	99.63%
T4085	Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
T4371	CD437	125316-60-1	99.63%
T4371	CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.
T1339	5-Azacytidine	320-67-2	99.62%
T1339	5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing ...
TQ0165	Arglabin	84692-91-1	99.62%
TQ0165	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
T27064	CP-312	895470-67-4	99.61%
T27064	CP-312 (Cardioprotectant 312) is an antioxidant defense response activator that protects hiPSC-CM viability by acting through induction of heme oxygenase-1 and t...
T6883	Samotolisib	1386874-06-1	99.61%
T6883	Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials stud...
T3015	Olaparib	763113-22-0	99.61%
T3015	Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is sel...
T3678	Entrectinib	1108743-60-7	99.61%
T3678	Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1....
T3077	SB 216763	280744-09-4	99.61%
T3077	SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).
T1611	Isotretinoin	4759-48-2	99.61%
T1611	Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cel...
T0093L	Sorafenib	284461-73-0	99.61%
T0093L	Sorafenib (Bay 43-9006) is a multikinase inhibitor that inhibits Raf-1, B-Raf, VEGFR2, VEGFR3, VEGFR4, PDGFRβ, FLT3, c-Kit, and others (IC50=6/22/90/15/20/20/57/...
T1795	Carfilzomib	868540-17-4	99.6%
T1795	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be u...
T3874	Diosgenin glucoside	14144-06-0	99.6%
T3874	Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis....
T0791	Reserpine	50-55-5	99.6%
T0791	Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage ves...
T3688	SR9011	1379686-29-9	99.6%
T3688	SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).
T0467	Sildenafil citrate	171599-83-0	99.59%
T0467	Sildenafil citrate (UK-92480 citrate) , a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erect...
T2933	Wogonin	632-85-9	99.59%
T2933	Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
T1207	Lovastatin	75330-75-5	99.59%
T1207	Lovastatin (MK-803) is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.
T4859	1-Monomyristin	589-68-4	99.58%
T4859	1-Monomyristin (2,3-Dihydroxypropyl tetradecanoate) , a 1-monoglyceride of myristic acid, has antibacterial activity against several Gram-positive bacterial stra...
T3109	SP600125	129-56-6	99.58%
T3109	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive proper...