Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
TMA1012	Ganoderiol F	114567-47-4	98%
TMA1012	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency viru...
T21332	U0126	109511-58-2	98%
T21332	U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively. U0126 inhi...
TN2646	16-Hydroxycleroda-3,13-dien-15,16-olide	141979-19-3	98%
TN2646	16-Hydroxycleroda-3,13-dien-15,16-olide, and prodigiosin are presented as candidates for autophagy inducers that can trigger cell death in a supplement or altern...
TN2118	Lup-20(29)-en-28-oic acid	848784-85-0	98%
TN2118	Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
TN3806	Dehydroglyasperin C	199331-35-6	98%
TN3806	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
T0956	Avermectin B1	71751-41-2	mixture
T0956	Avermectin B1 is served as anthelmintic and insecticide.
T6531	Heparin sodium salt	9041-08-1	BR
T6531	Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse pr...
T6927	Pamapimod	449811-01-2	99.99%
T6927	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with ...
T2154	MG-132	133407-82-6	99.99%
T2154	MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induc...
T2590	Vismodegib	879085-55-9	99.99%
T2590	Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
T3492	PD-166866	192705-79-6	99.98%
T3492	PD-166866 is a selective FGFR tyrosine kinase inhibitor.
T0101	Doxazosin mesylate	77883-43-3	99.98%
T0101	Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.
T2731	Usnic Acid	125-46-2	99.98%
T2731	Usnic Acid (Usniacin) is an antimicrobial, antitumor and enzyme inhibiting agent shown to uncouple oxidative phosphorylation in mouse-liver mitochondria. Usnic a...
T0335	Sodium salicylate	54-21-7	99.98%
T0335	Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T4S1102	Liensinine diperchlorate	5088-90-4	99.98%
T4S1102	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome...
T8200	Ginkgolide K	153355-70-5	99.98%
T8200	Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.
T0750	Sulfisoxazole	127-69-5	99.98%
T0750	Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfiso...
T8689	Chloroquine	54-05-7	99.98%
T8689	Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the tre...
T0828	Bromhexine hydrochloride	611-75-6	99.98%
T0828	Bromhexine hydrochloride (Bisolvon) is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
T6300	Degrasyn	856243-80-6	99.98%
T6300	Degrasyn (WP1130) (WP1130), a specific deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor, also inhibits Bcr/Abl, which is a JAK2 transducer (...