Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T1829	Ruxolitinib	941678-49-5	99.93%
T1829	Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and ...
T6010	Idarubicin hydrochloride	57852-57-0	99.93%
T6010	Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).
T0968	Paclitaxel	33069-62-4	99.92%
T0968	Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest...
T8840	PF-543 hydrochloride	1706522-79-3	99.92%
T8840	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isofo...
T0486L	Irinotecan Hydrochloride	100286-90-6	99.92%
T0486L	Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a...
T1272	Cytarabine	147-94-4	99.92%
T1272	Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophag...
TN1965	N-Benzyllinolenamide	883715-18-2	99.92%
TN1965	N-Benzyllinolenamide is a natural product. It is an inhibitor of fatty acid amide hydrolase (FAAH, IC50 of 41.8 μM).
T6228	Irinotecan	97682-44-5	99.92%
T6228	Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand re...
T6S1688	(1E,6E)-Bis(demethoxy)curcumin	33171-05-0	99.92%
T6S1688	(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.
T0499	Oxybenzone	131-57-7	99.92%
T0499	Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.
T0676	Hydroxyurea	127-07-1	99.92%
T0676	Hydroxyurea (Hydroxycarbamide), an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
T2363	STF-31	724741-75-7	99.92%
T2363	STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.
T0189L	Pemetrexed disodium	150399-23-8	99.92%
T0189L	Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer an...
T6468	D-glutamine	5959-95-5	99.92%
T6468	D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.
T14853	Cabergoline	81409-90-7	99.92%
T14853	Cabergoline (FCE-21336) is an ergot derived-dopamine D2-like receptor agonist. It has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respe...
T7149	S29434	874484-20-5	99.92%
T7149	S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).
T4398	LX2343	333745-53-2	99.92%
T4398	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
T2843	Aloe emodin	481-72-1	99.91%
T2843	Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.
T2926	Schizandrin A	61281-38-7	99.91%
T2926	Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM ...
T2248	AS-605240	648450-29-7	99.91%
T2248	AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).