Autophagy

Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or disfunctional components. It allows the orderly degradation and recycling of cellular components. Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome, which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled.

Cat. No.	Product name	CAS No.	Purity
T3215	JNJ-42165279	1346528-50-4	99.89%
T3215	JNJ-42165279 covalently inactivates the FAAH enzyme but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279...
T6947	Piperlongumine	20069-09-4	99.89%
T6947	Piperlongumine (Piplartine) is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (RO...
T1434	Clarithromycin	81103-11-9	99.89%
T1434	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A In...
T0078	Lapatinib	231277-92-2	99.89%
T0078	Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity. Lapatinib has antitumor activity and can be used to treat advanced ...
T0826	Meloxicam	71125-38-7	99.89%
T0826	Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification ...
T2726	Sinomenine	115-53-7	99.89%
T2726	Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.
T1848	Dynasore	304448-55-3	99.89%
T1848	Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-fre...
T5854	AM580	102121-60-8	99.89%
T5854	AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )
T2654	GSK2656157	1337532-29-2	99.89%
T2654	GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T6797	Telaglenastat	1439399-58-2	99.89%
T6797	Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.
T2577	Dienogest	65928-58-7	99.89%
T2577	Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory a...
T2125	Trametinib	871700-17-3	99.88%
T2125	Trametinib (GSK1120212) is a MEK inhibitor that inhibits MEK1 and MEK2 (IC50=0.7/0.9 nM) with ATP non-competitive and oral activity. Trametinib activates autopha...
T12352L	Oxidopamine hydrobromide	636-00-0	99.88%
T12352L	Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.
T2615	Flavopiridol hydrochloride	131740-09-5	99.88%
T2615	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib ...
T1093	Adapalene	106685-40-9	99.88%
T1093	Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.
T12998	SR10067	1380548-02-6	99.88%
T12998	SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbα/β(IC50 of 160 and 170 nM for Rev-Erbβ and Rev-Erbα, respectively),has anxiolytic activity....
T5312	CFTR corrector 2	1628416-28-3	99.88%
T5312	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients w...
T0943	Carbamazepine	298-46-4	99.88%
T0943	Carbamazepine (NSC-169864) is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazep...
T6377	Aloperine	56293-29-9	99.88%
T6377	Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
TN1140	Onjisaponin B	35906-36-6	99.88%
TN1140	Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy...