BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.

Cat. No.	Product name	CAS No.	Purity
TN2217	Sophoflavescenol	216450-65-6	99.65%
TN2217	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
TN3410	Anatabine	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4865	Putraflavone	23624-21-7	98%
TN4865	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN2131	Questin	3774-64-9	98%
TN2131	Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
TN1332	7-O-Methylaloeresin A	329361-25-3	98%
TN1332	7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
T10292	AM-6494	1874232-80-0	98%
T10292	AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T10450	BACE1-IN-1	1310347-50-2	98%
T10450	BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
TN1434	Bavachromene	41743-38-8	98%
TN1434	Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T8306	Epiberberine chloride	889665-86-5	98%
T8306	Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
T10452	BACE1-IN-4	2361157-92-6	98%
T10452	BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T12429	PF-06751979	1818339-66-0	98%
T12429	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TQ0238	Lanabecestat	1383982-64-6	98%
TQ0238	Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T14338	Atabecestat	1200493-78-2	98%
T14338	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
TN4399	Kushenol C	99119-73-0	98%
TN4399	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T10453	BACE1-IN-5	2581114-83-0	98%
T10453	BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM...
T10451	BACE1-IN-2	1352416-78-4	98%
T10451	BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T6058	LY2886721	1262036-50-9	99.94%
T6058	LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T6772	AZD3839 free base	1227163-84-9	99.93%
T6772	AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T4398	LX2343	333745-53-2	99.92%
T4398	LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
TN1343	8-Geranyloxypsoralen	7437-55-0	99.87%
TN1343	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arter...