BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product name	CAS No.	Purity
T5108	ML311	315698-17-0	99.75%
T5108	ML311 is a selective inhibitor of the Mcl-1/Bim interaction.
T3344	Ciwujianoside B	114902-16-8	99.73%
T3344	Ciwujianoside B (acanthopanax senticosides B) is the main component of Acanthopanax, can relieve fatigue, enhance memory, and improve human cognition.
T5S0993	Kurarinone	34981-26-5	99.72%
T5S0993	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong ...
T14376	AZD4320	1357576-48-7	99.71%
T14376	AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectively...
T9113	Myristicin	607-91-0	99.63%
T9113	Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effe...
T3867	Alpinetin	36052-37-6	99.61%
T3867	Alpinetin ((-)-alpinetin) has antibacterial activity.Alpinetin has anti-inflammatory activity.Alpinetin can enhance the sensitivity of HepG2 hepatoma cells to th...
T5210	BAI1	335165-68-9	99.58%
T5210	BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
T7727	Se-Methylselenocysteine	26046-90-2	99.49%
T7727	Se-Methylselenocysteine (Se-MSC) is a potent chemopreventive agent in many test systems and has been shown to inhibit tumor promotion and induce apoptosis.
T17247	VU0661013	2131184-57-9	99.46%
T17247	VU0661013 is an effective and selective inhibitor of MCL-1.
T6275	Obatoclax Mesylate	803712-79-0	99.38%
T6275	Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and activatio...
T7979	2-Hydroxychalcone	644-78-0	99.38%
T7979	2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breas...
TN1918	Medicarpin	32383-76-9	99.32%
TN1918	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
T2099	ABT-737	852808-04-9	99.3%
T2099	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).
T12629L	MIK665	1799631-75-6	99.28%
T12629L	MIK665 (S-64315) (S-64315) has an inhibitory effect on myeloid leukemia.
T38622	Bcl-xL antagonist 2	1235032-75-3	99.26%
T38622	Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer c...
T2453	BAM7	331244-89-4	99.23%
T2453	BAM 7 is a direct and specific activator of proapoptotic Bax (EC50: 3.3 μM).
T2101	Navitoclax	923564-51-6	99.22%
T2101	Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activ...
TN1891	Lupiwighteone	104691-86-3	99.20%
TN1891	Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.
T5104	BTSA1	314761-14-3	99.15%
T5104	BTSA1 is a BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX...
T1119	Rasagiline	136236-51-6	99.14%
T1119	Rasagiline (AGN1135) is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons di...