BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product name	CAS No.	Purity
T3697	3',6-Disinapoylsucrose	139891-98-8	99.02%
T3697	3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.
T12824L	S55746	1448584-12-0	98.99%
T12824L	S55746 (BLC201) is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
T4088	Thymoquinone	490-91-5	98.98%
T4088	Thymoquinone (NSC 2228) is a compound be found in herbs and spices with anti-inflammatory and anti-oxidant effects.
T14846	Bz 423	216691-95-1	98.89%
T14846	Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c rele...
T2101	Navitoclax	923564-51-6	98.88%
T2101	Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activ...
T6034	UMI-77	518303-20-3	98.88%
T6034	UMI-77, a specific Mcl-1 inhibitor (Ki: 490 nM), has selectivity over other members of Bcl-2 family.
T6S0052	Chelerythrine	34316-15-9	98.86%
T6S0052	1. Chelerythrine (Broussonpapyrine) may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine is a well-known protein kinase...
T3419	Chelerythrine chloride	3895-92-9	98.78%
T3419	Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the phosphate acceptor and non-competitive with respect to ...
T1901	(E/Z)-TG003	300801-52-9	98.73%
T1901	(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.
T4S0181	Hinokiflavone	19202-36-9	98.67%
T4S0181	Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the ...
T2730	Gossypol (acetic acid)	12542-36-8	98.57%
T2730	Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.
T5346	S63845	1799633-27-4	98.56%
T5346	S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)
T6650	Sabutoclax	1228108-65-3	98.5%
T6650	Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively...
T6185	Gambogic Acid	2752-65-0	98.38%
T6185	Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC5...
T5S2358	Dehydrocorydaline	30045-16-0	98.36%
T5S2358	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
T3864	Erianin	95041-90-0	98.22%
T3864	Erianin is a nature product extracted from Dendrobium chrysotoxum, has notable antitumour activity , can cause extensive tumour necrosis, growth delay. Erianin h...
T1493	BH3I-1	300817-68-9	98.2%
T1493	BH3I-1 (BHI1) is a Bcl-2 antagonist.
T4089	FX1	1426138-42-2	98.15%
T4089	FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM).
T6749	A-1331852	1430844-80-6	98.15%
T6749	A-1331852 is a potent and selectiveBCL-XL inhibitor and may be useful in the treatment of cancer, immune and autoimmune diseases.
T9083	TC11	100823-03-8	98.1%
T9083	TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis vi...