T17018 |
TCPOBOP
|
76150-91-9
|
98.08%
|
|
TCPOBOP is a constitutive androstane receptor agonist that induces robust hepatocyte proliferation and hepatomegaly. TCPOBOP decreases Fas-induced murine liver i...
|
T16028 |
IMB-XH1
|
292057-76-2
|
98%
|
|
IMB-XH1 (Mcl1-IN-2) is a myeloid cell factor 1 (Mcl-1) inhibitor.
|
T5668 |
Triacetylresveratrol
|
42206-94-0
|
98%
|
|
Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulate...
|
T6281 |
TW-37
|
877877-35-5
|
98%
|
|
TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).
|
T6748 |
A-1155463
|
1235034-55-5
|
98%
|
|
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related protein...
|
T1980 |
HA14-1
|
65673-63-4
|
98%
|
|
HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM).
|
T5679 |
(E)-Ferulic acid
|
537-98-4
|
98%
|
|
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of ...
|
T77571 |
Bcl-B inhibitor 1
|
79220-88-5
|
97.77%
|
|
Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.
|
T11944 |
Maritoclax
|
1227962-62-0
|
97.70%
|
|
Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value o...
|
T14071 |
A-385358
|
406228-55-5
|
97.40%
|
|
A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.
|
TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
T10487 |
BCL6-IN-3
|
2253878-44-1
|
97.25%
|
|
BCL6-IN-3 is a potent BCL6 inhibitor with GI50 of 70 nM in SU-DHL4 cells. BCL6-in-3 regulates cell activation, differentiation, DNA damage and apoptosis, and has...
|
T10483 |
Lisaftoclax
|
2180923-05-9
|
97.14%
|
|
Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lis...
|
T6396 |
(R)-(-)-Gossypol acetic acid
|
866541-93-7
|
96.73%
|
|
(R)-(-)-Gossypol acetic acid (AT101 acetate) , the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0...
|
TP1724L |
PUMA BH3 acetate
|
|
96.64%
|
|
PUMA BH3 acetate (PUMA BH3 Free base) is a p53 positive regulator of apoptosis (PUMA) BH3 domain polypeptide that acts as a direct activator of Bak with a Kd of ...
|
T0448 |
(S)-(+)-Ibuprofen
|
51146-56-6
|
100%
|
|
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
|
T2632 |
A-1210477
|
1668553-26-1
|
|
|
A-1210477 is an effective and specific MCL-1 and Bcl-2 inhibitor (Ki/IC50: 0.454/26.2 nM).
|
TN3967 |
Epieriocalyxin A
|
191545-24-1
|
|
|
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
|
T0186 |
Docetaxel trihydrate
|
148408-66-6
|
|
|
Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currentl...
|
T60008 |
BCL6-IN-6
|
2408882-54-0
|
98%
|
|
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressor...
|