BTK

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.

Cat. No.	Product name	CAS No.	Purity
T8636	Ibrutinib deacryloylpiperidine	330786-24-8	99.8%
T8636	Ibrutinib deacryloylpiperidine (IBT4A) is a highly selective Bruton’s tyrosine kinase (BTK) irreversible inhibitor with an IC50 of 0.5 nM.
T4337	PCI 29732	330786-25-9	99.79%
T4337	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
T1835	Ibrutinib	936563-96-1	99.76%
T1835	Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
TQ0236	Tirabrutinib	1351636-18-4	99.75%
TQ0236	Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM....
T17098	Tilfrinib	1600515-49-8	99.73%
T17098	Tilfrinib is an effective and selective inhibitor of breast tumor kinase(Brk, IC50 = 3.15 nM) which displays anti-proliferative and anti-tumor activities.
T14323	ARQ 531	2095393-15-8	99.59%
T14323	ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectiv...
T10629	Btk inhibitor 2	1558036-85-3	99.49%
T10629	Btk inhibitor 2 (BGB-3111 analog) is a BTK inhibitor.
T63272	Edralbrutinib	1858206-58-2	99.47%
T63272	Edralbrutinib (TG-1701) is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood and lymphat...
T12317	Orelabrutinib	1655504-04-3	99.44%
T12317	Orelabrutinib (ICP-022) is an orally active and irreversible inhibitor of Bruton's tyrosine kinase (BTK).
T3626	Acalabrutinib	1420477-60-6	99.43%
T3626	Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon a...
T1976	RN486	1242156-23-5	99.38%
T1976	RN486 is an effective and specific BTK inhibitor (IC50: 4 nM).
T16730	Remibrutinib	1787294-07-8	99.34%
T16730	Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib is an effective and orally active Bruton tyrosine kinase inhibitor (IC50...
T9706	BTK inhibitor 17	1858206-76-4	99.29%
T9706	BTK inhibitor 17 is a potent irreversible BTK inhibitor (IC50 = 2.1 nM). BTK inhibitor 17 can be used in rheumatoid arthritis studies.
T6921	ONO-4059 analog	1351635-67-0	99.25%
T6921	ONO-4059 analog (ONO-WG-307)ue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1.
T7584	Zanubrutinib	1691249-45-2	99.24%
T7584	Zanubrutinib (BGB-3111) is an inhibitor of Bruton tyrosine kinase (BTK).
T9125	Tolebrutinib	1971920-73-6	99.2%
T9125	Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells ...
T5138	BMS-986142	1643368-58-4	99.13%
T5138	BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).
T2302	CNX-774	1202759-32-7	99.1%
T2302	CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
T35330	BTK inhibitor 1	2230724-66-8	99.06%
T35330	BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.
TQ0230	BTK IN-1	1270014-40-8	98.98%
TQ0230	BTK IN-1 (SNS062 analog) (SNS062 analog) is an effective BTK inhibitor (IC50: <100 nM).