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Neuroscience Beta Amyloid

Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Cat No. product name
T0883 Homotaurine Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties.
T2262 CHF5074 CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
T2625 MK0752 MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T2639 LY2811376 LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...
T3394 Timosaponin BII Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
T6274 RO4929097HOT RO4929097, a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
T6495 EUK 134 EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related a...
T4422 Edonerpic maleate Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
T5810 TABERSONINE HYDROCHLORIDE TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(142) aggregation and toxicity.
T7490 ARN2966 ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
T7527 Frentizole Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
TQ0026 MDR-1339 MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
T7562 β-Amyloid 31-35(TFA) β-Amyloid 31-35(TFA) is the shortest sequence of native Amyloid-β peptide.
T6202 DAPTHOT DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
T4077 PE859 PE859 is a potent inhibitor of both tau and Aβ aggregation.
T8012 Scyllo-Inositol Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's diseas...
T7905 PBD-150 PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
T7680 GSNKGAIIGLM(131602-53-4(free base)) GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
TN1091 Dehydronuciferine Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN1712 Gossypin Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits th...
TN1341 8-Deoxygartanin 8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it h...
TN1725 Hederacolchiside E Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by ...
TN1798 Isorosmanol Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions...
TN1919 Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in t...
TN1038 Galgravin Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
TN1116 Schisandrone Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under act...
TN2082 Pinostrobin Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibit...
TN2100 Pratensein Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
T14525 Begacestat Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's dise...
T14673 BMS 299897 BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor...
T10453 BACE1-IN-5 BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
T19011 Hoechst 34580 Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T19013 Hoechst 34580 tetrahydrochloride Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
TP1856 Colivelin Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
TMS1461 Otophylloside B Otophylloside B shows anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in...
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and m...
TN3410 Anatabine Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
TN3618 Cedrin Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative...
TN4571 Mirabijalone D Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
TN4635 Neoechinulin A Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
TN4865 Putraflavone Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
T19892 BSBM7 BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
Homotaurine
T0883CAS 3687-18-1
Piroxicam is a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties.
CHF5074
T2262CAS 749269-83-8
CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
MK0752
T2625CAS 471905-41-6
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
LY2811376
T2639CAS 1194044-20-6
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectiv...
Timosaponin BII
T3394CAS 136656-07-0
Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-...
RO4929097 HOT
T6274CAS 847925-91-1
RO4929097, a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).
EUK 134
T6495CAS 81065-76-1
EUK 134, a synthetic superoxide dismutase (SOD)/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related a...
Edonerpic maleate
T4422CAS 519187-97-4
Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
TABERSONINE HYDROCHLORIDE
T5810CAS 29479-00-3
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(142) aggregation and toxicity.
ARN2966
T7490CAS 102212-26-0
ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.
Frentizole
T7527CAS 26130-02-9
Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction
MDR-1339
TQ0026CAS 1018946-38-7
MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
β-Amyloid 31-35(TFA)
T7562CAS 149385-65-9
β-Amyloid 31-35(TFA) is the shortest sequence of native Amyloid-β peptide.
DAPT HOT
T6202CAS 208255-80-5
DAPT is a novel γ-secretase inhibitor which reduces the Aβ production (IC50: 20 nM in HEK 293 cells) and Aβ42 levels (IC50: 200 nM).
PE859
T4077CAS 1402727-29-0
PE859 is a potent inhibitor of both tau and Aβ aggregation.
Scyllo-Inositol
T8012CAS 488-59-5
Scyllo-Inositol is one of the inositol stereoisomers, rare in the nature, and expected as a promising disease-modifying therapeutic agent for Alzheimer's diseas...
PBD-150
T7905CAS 790663-33-1
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
GSNKGAIIGLM(131602-53-4(free base))
T7680CAS T7680
GSNKGAIIGLM is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide.
Dehydronuciferine
TN1091CAS 7630-74-2
Dehydronuciferine shows inhibitory of acetylcholinesterase with the IC50 of 25 ug/mL.
Fustin
TN1653CAS 20725-03-5
Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
Gossypin
TN1712CAS 652-78-8
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits th...
8-Deoxygartanin
TN1341CAS 33390-41-9
8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α²-amyloid (Aα²) aggregation, it h...
Hederacolchiside E
TN1725CAS 33783-82-3
Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by ...
Isorosmanol
TN1798CAS 93780-80-4
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions...
Medioresinol
TN1919CAS 40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in t...
Galgravin
TN1038CAS 528-63-2
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloi...
Schisandrone
TN1116CAS 98619-25-1
Schisandrone has strong activities of anti-oxidation, effectively scavenges hydroxyl radical and superoxide anion, and has protective effects on cells under act...
Pinostrobin
TN2082CAS 480-37-5
Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibit...
Pratensein
TN2100CAS 2284-31-3
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells.
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142CAS 566169-98-0
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
Begacestat
T14525CAS 769169-27-9
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's dise...
BMS 299897
T14673CAS 290315-45-6
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor...
BACE1-IN-5
T10453CAS
BACE1-IN-5 is a BACE1 inhibitor (IC50: 9.1 nM) and also inhibits cellular amyloid-β (Aβ; IC50: 0.82 nM). BACE1-IN-5 has medicinal chemistry that improves hERG...
Hoechst 34580
T19011CAS 23555-00-2
Hoechst 34580, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Hoechst 34580 tetrahydrochloride
T19013CAS NA
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Colivelin
TP1856CAS 867021-83-8
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
Otophylloside B
TMS1461CAS 106758-54-7
Otophylloside B shows anti-aging effects, it can extend lifespan, increase heat stress-resistance, delay body paralysis, and increase the chemotaxis response in...
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218CAS 100667-52-5
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and m...
Anatabine
TN3410CAS 581-49-7
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheim...
Cedrin
TN3618CAS 75513-81-4
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative...
Mirabijalone D
TN4571CAS 485811-84-5
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
Neoechinulin A
TN4635CAS 51551-29-2
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block t...
Putraflavone
TN4865CAS 23624-21-7
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
BSBM7
T19892CAS 6968/11/2
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.