Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.

Cat. No.	Product name	CAS No.	Purity
T11043	Dihydroergocristine mesylate	24730-10-7	99.51%
T11043	Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomati...
T67751	1H-Indole-3-carboxylic acid, 5-[2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propoxy]-2-methyl-1-(4-methylphenyl)-, ethyl ester	539807-13-1	99.44%
T67751	Compound 5936-0108 may has modulationg effect on β-Amyloid.
T9713	δ-secretase inhibitor 11	842964-18-5	99.4%
T9713	δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
TN2082	Pinostrobin	480-37-5	99.35%
TN2082	Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα²(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting...
T12532	PQM130	2089415-51-8	99.31%
T12532	PQM130 is a neuroprotective compound ,and is a potential anti-AD drug.
T3259	FPS-ZM1	945714-67-0	99.3%
T3259	FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
T14690	BMS 433796	935525-13-6	99.17%
T14690	BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.
T6125	Semagacestat	425386-60-3	99.11%
T6125	Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).
T6S1918	Schisantherin B	58546-55-7	99.06%
T6S1918	1. Schisantherin B (Schizantherin-B) shows good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hep...
T4364	Aftin-4	866893-90-5	99.03%
T4364	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin...
T2639	LY2811376	1194044-20-6	99.01%
T2639	LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
T2777	Ginsenoside Rg1	22427-39-0	99%
T2777	Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spat...
T0883	Tramiprosate	3687-18-1	99%
T0883	Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble A...
T2625	MK-0752	471905-41-6	98.99%
T2625	MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T3402	20(S)-Ginsenoside Rg3	14197-60-5	98.99%
T3402	20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
T19011L	Hoechst 34580 xHCl(23555-00-2(free base)	T19011L	98.89%
T19011L	Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T2212	Geniposide	24512-63-8	98.78%
T2212	Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activit...
T5447	Anle138b	882697-00-9	98.76%
T5447	Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
TP2419	V-9-M Cholecystokinin nonapeptide	99291-20-0	98.75%
TP2419	V-9-M Cholecystokinin nonapeptide (Prepro CCK Fragment V-9-M) is a precursor compound of cholecystokinin (CCK). Cholecystokinin (CCK) is a brain-intestinal pepti...
TMS1461	Qingyangshengenin B	106758-54-7	98.56%
TMS1461	Qingyangshengenin B (Otophylloside B) is a C-21 steroidal glycoside isolated from Qingyangshen. Qingyangshengenin B protects against Aβ toxicity, which decreases...