CCR

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

Cat. No.	Product name	CAS No.	Purity
T2386	Pirfenidone	53179-13-8	99.93%
T2386	Pirfenidone (AMR69) is an inhibitor for TGF-β production and TGF-β stimulated collagen production. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, ...
T4300	AZD2098	566203-88-1	99.92%
T4300	AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.
T16111	ML604086	850330-18-6	99.91%
T16111	ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 bi...
T3188	RE-640	140926-75-6	99.91%
T3188	NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.
T60145	CCR6 antagonist 1	588674-64-0	99.89%
T60145	CCR6 antagonist 1, a chemical compound acting as a CCR6 antagonist, effectively inhibits the CCL20/CCR6 axis. Its utility lies in research focused on autoimmune-...
T2375	BX471	217645-70-0	99.85%
T2375	BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.
T10156	CCR3 antagonist 1	879399-82-3	99.85%
T10156	CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.
T11481	GSK2239633A	1240516-71-5	99.78%
T11481	GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.
T3327	Artemotil	75887-54-6	99.76%
T3327	Artemotil (SM-227) is a new, fast-acting antimalarial drug.
T30258	AZD-4818	1003566-93-5	99.75%
T30258	AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease.
T15641	K777	233277-99-1	99.71%
T15641	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 a...
T12773	RS102895 hydrochloride	1173022-16-6	99.7%
T12773	RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).
T4584	BMS-813160	1286279-29-5	99.66%
T4584	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
T14900	CCR2-RA-[R]	512177-83-2	99.65%
T14900	CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).
TN1273	7,4'-Dihydroxyflavone	2196-14-7	99.6%
TN1273	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) can induce transcription of nodulation (nod) genes in Rhizobium meliloti. It has inhibitory activities against COX-...
T7499	TAK-779	229005-80-5	99.58%
T7499	TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
TQ0283	RS102895	300815-41-2	99.54%
TQ0283	RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1.
T3430	PF-4136309	1341224-83-6	99.52%
T3430	PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.
T17225	Vercirnon	698394-73-9	99.15%
T17225	Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.
T23321	SB 328437	247580-43-4	99.11%
T23321	SB 328437 ((S)-methyl 2-(1-naphthamido)-3-(4-nitrophenyl)propanoate) is an effective and selective antagonist of CCR3 (IC50 = 4.5 nM).