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CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T13044 Mevociclib 1816989-16-8 98.02%
Mevociclib
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
T2653 SB1317 1204918-72-8 100%
SB1317
SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
T1947 BS-181 1092443-52-1
BS-181
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
TN1663 Ganoderic acid DM 173075-45-1 98%
Ganoderic acid DM
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
T17305 CDK8-IN-4 1613638-82-6 98%
CDK8-IN-4
CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
TN4394 Kobophenol A 124027-58-3 98%
Kobophenol A
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T12617 (R)-CR8 trihydrochloride 1786438-30-9 98%
(R)-CR8 trihydrochloride
(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
T5438 PROTAC CDK9 Degrader-1 2118356-96-8 98%
PROTAC CDK9 Degrader-1
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
T77923 BSJ-03-204 triTFA 98%
BSJ-03-204 triTFA
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degrada...
T78048 Rel-(2S,3R)-Voruciclib hydrochloride 1253647-46-9 98%
rel-(2S,3R)-Voruciclib hydrochloride
Rel-(2S,3R)-Voruciclib hydrochloride is an enantiomer of Voruciclib hydrochloride, an orally active cyclin-dependent kinase (CDK) inhibitor.
T78137 Avotaciclib hydrochloride 98%
Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including ...
T78813 CDK2/Bcl2-IN-1 98%
CDK2/Bcl2-IN-1
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibi...
T78837 CP-07 98%
CP-07
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formation by...
T79014 QR-6401 2845096-18-4 98%
QR-6401
QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/D...
T79037 CDK9-IN-23 2761572-96-5 98%
CDK9-IN-23
CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].
T79046 CDK4-IN-2 2380320-68-1 98%
CDK4-IN-2
CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].
T79112 CDK4/6-IN-17 2035069-96-4 98%
CDK4/6-IN-17
CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells. It has...
T79169 CDK7-IN-22 2173190-60-6 98%
CDK7-IN-22
CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].
T79354 CDK9-IN-24 98%
CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation. It impedes cell growth...
T79367 CDK9-IN-27 98%
CDK9-IN-27
CDK9-IN-27 (Compound 6a), a CDK9 inhibitor with an IC50 of 0.424 μM, induces apoptosis and S-phase cell cycle arrest. It exhibits cytotoxicity against HepG2, HCT...
Mevociclib
T13044
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.
SB1317
T2653
SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
BS-181
T1947
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
Ganoderic acid DM
TN1663
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 ...
CDK8-IN-4
T17305
CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
(R)-CR8 trihydrochloride
T12617
(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
PROTAC CDK9 Degrader-1
T5438
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
BSJ-03-204 triTFA
T77923
BSJ-03-204 triTFA is a potent and selective Cereblon- and CDK-targeted PROTAC (PROteolysis TArgeting Chimera) featuring Palbociclib-based ligands for the degrada...
rel-(2S,3R)-Voruciclib hydrochloride
T78048
Rel-(2S,3R)-Voruciclib hydrochloride is an enantiomer of Voruciclib hydrochloride, an orally active cyclin-dependent kinase (CDK) inhibitor.
Avotaciclib hydrochloride
T78137
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, including ...
CDK2/Bcl2-IN-1
T78813
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells. Additionally, it inhibi...
CP-07
T78837
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formation by...
QR-6401
T79014
QR-6401, a selective macrocyclic CDK2 inhibitor, is orally active with IC50 values of 0.37 nM for CDK2/E1, 10 nM for CDK9/T1, 22 nM for CDK1/A2, 34 nM for CDK6/D...
CDK9-IN-23
T79037
CDK9-IN-23 (Example 4) is a potent inhibitor of CDK9, exhibiting an IC50 value of less than 20 nM [1].
CDK4-IN-2
T79046
CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].
CDK4/6-IN-17
T79112
CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells. It has...
CDK7-IN-22
T79169
CDK7-IN-22 (compound 101) is a selective CDK7 inhibitor that exhibits antitumor activity, demonstrating specificity for CDK7 [1].
CDK9-IN-24
T79354
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation. It impedes cell growth...
CDK9-IN-27
T79367
CDK9-IN-27 (Compound 6a), a CDK9 inhibitor with an IC50 of 0.424 μM, induces apoptosis and S-phase cell cycle arrest. It exhibits cytotoxicity against HepG2, HCT...
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TargetMol