CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T4205	AG-494	133550-35-3	98.9%
T4205	AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
T5S1467	Cucurbitacin E	18444-66-1	98.88%
T5S1467	Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cuc...
T2670	ML167	1285702-20-6	98.85%
T2670	ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
T21966	MeBIO	667463-95-8	98.84%
T21966	MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.
T36933	Cdk2 Inhibitor II	222035-13-4	98.84%
T36933	Cdk2 Inhibitor II is a selective and potent CDK2 inhibitor50 at 60 nM.
T70388L	(R)-Enitociclib	1610408-96-2	98.82%
T70388L	(R)-Enitociclib, an enantiomer of BAY-1251152, is a CDK9 inhibitor with anticancer activity.
T14778	BRD6989	642008-81-9	98.82%
T14778	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant C...
T24580	P18IN003	71727-40-7	98.77%
T24580	P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion of hematopoietic...
T10746	CDK9-IN-8	2105956-51-0	98.77%
T10746	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).
T77341	GSK-3 inhibitor 4	2227279-83-4	98.77%
T77341	GSK-3 inhibitor 4 is an orally active and brain-permeable triple inhibitor of GSK-3, CDK2 and CDK5 with inhibitory effects on GSK-3β, GSK-3α, CDK2 and CDK5, with...
TN1068	Tricin	520-32-1	98.76%
TN1068	Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregul...
T1901	(E/Z)-TG003	300801-52-9	98.73%
T1901	(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.
T23897	CLK1/2-IN-3	1005784-60-0	98.71%
T23897	CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, an...
TQ0053	Fadraciclib	1070790-89-4	98.71%
TQ0053	Fadraciclib (CYC065) is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM).
TN2080	Pinoresinol	487-36-5	98.67%
TN2080	Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, ...
T4482	CC-671	1618658-88-0	98.65%
T4482	CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.
T9712	PF07104091	2460249-19-6	98.61%
T9712	PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.
T23284	Ryuvidine	265312-55-8	98.6%
T23284	Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and ...
T36694	XY028-140	2229974-83-6	98.59%
T36694	XY028-140 is a selective CDK4/CDK6 degrade and inhibits both CDK4/6 expression and activity in cancer cells. XY028-140 is a PROTAC connected by ligands for Cereb...
T61448	AZA1	1071098-42-4	98.59%
T61448	AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration ...