T60619 |
CDK9-IN-15
|
852678-17-2
|
97.24%
|
|
CDK9-IN-15 is a potent small molecule CDK9 inhibitor, which can block the phosphorylation of positive transcription elongation factor b (P-TEFb) on the C-termina...
|
T10727 |
Cdc7-IN-5
|
1402057-86-6
|
97.15%
|
|
Cdc7-IN-5 is a potent inhibitor of Cdc7 kinase. Cdc7, a serine-threonine protein kinase enzyme, is essential for the initiation of DNA replication in the cell cy...
|
T10740 |
CDK8-IN-1
|
1629633-48-2
|
97.09%
|
|
CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).
|
T6458 |
CYC-116
|
693228-63-6
|
96.6%
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
|
T15335 |
FN-1501
|
1429515-59-2
|
96.35%
|
|
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1...
|
T37207L |
Cdk5 Substrate acetate
|
|
96.21%
|
|
Cyclin-dependent kinase 5 (Cdk5) is a serine/threonine kinase that is predominantly active in neuronal tissues. With p25 or p35, Cdk5 phosphorylates a range of p...
|
TQ0060 |
LY2857785
|
1619903-54-6
|
96.00%
|
|
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM).
|
T39957 |
CDK4/6-IN-6
|
2380321-51-5
|
95.63%
|
|
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
|
T69188 |
Aloisine B
|
496864-14-3
|
95.15%
|
|
Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiv...
|
T3664 |
THZ1
|
1604810-83-4
|
95.09%
|
|
THZ1 (CDK7 inhibitor) is a novel selective and potent covalent CDK7 inhibitor.
|
T19913 |
CKI-7
|
1177141-67-1
|
100.00%
|
|
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
|
T3352 |
XL413
|
1169558-38-6
|
100%
|
|
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the a...
|
T7810 |
LY3177833
|
1627696-51-8
|
100%
|
|
LY3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)
|
T10773 |
CF53
|
1808160-52-2
|
100%
|
|
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to b...
|
T2095 |
Seliciclib
|
186692-46-6
|
100%
|
|
Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.6...
|
T8378 |
AS2863619
|
2241300-51-4
|
100%
|
|
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
|
T39608 |
Cirtuvivint
|
2143917-62-6
|
100%
|
|
Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.
|
T2113 |
PHA-793887
|
718630-59-2
|
100%
|
|
PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.
|
T60152 |
AZ5576
|
2751721-40-9
|
100%
|
|
AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].
|
T8230 |
PNU112455A hydrochloride
|
21886-12-4
|
100%
|
|
PNU112455A hydrochloride is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively.
|