CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T10172	5-Iodo-indirubin-3'-monoxime	331467-03-9	98%
T10172	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s:...
T13309	Voruciclib hydrochloride	1000023-05-1	98%
T13309	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
TMA1743	Ergosterol peroxide	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T72507	Palbociclib orotate	2757498-64-7	98%
T72507	Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively. This compound demons...
T74852	PROTAC CDK9 degrader-6	2935587-91-8	98%
T74852	PROTAC CDK9 degrader-6 is a specific PROTAC targeting CDK9 that mediates its degradation through the proteasome pathway. This compound effectively degrades CDK9 ...
T2082	CDK4-IN-1	1256963-02-6	98%
T2082	CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=...
T13627	CP-10	2366268-80-4	98%
T13627	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
T10724	Cdc7-IN-1	1402055-25-7	98%
T10724	Cdc7-IN-1 is a highly selective and ATP competitive inhibitor of Cdc7 kinase (IC50: 0.6 nM at 1 mM ATP). It potently inhibits Cdc7 activity in cancer cells and e...
T67780	AM5992	1169694-98-7	98%
T67780	AM5992 (example 195) is a potent CDK4 and CDK6 inhibitor (CDK4, IC50= 0.013 μM). AM5992 can be used for the research of CDK4-mediated disorders.
TN4411	Lappaol F	69394-17-8	98%
TN4411	1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. 2. Lap...
TN3719	Cristacarpin	74515-47-2	98%
TN3719	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
T11345	Lerociclib	1628256-23-4	98%
T11345	Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
T11632	IIIM-290	2213468-64-3	98%
T11632	IIIM-290 is an oral CDK inhibitor (IC50s: 90 and 94 nM for CDK2/A and CDK9/T1).
T10747	CDK9-IN-9	2246956-84-1	98%
T10747	CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM).
T12552	PROTAC CDK2/9 Degrader-1	2408641-24-5	98%
T12552	PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM).
T10741	CDK9-IN-1	1415559-43-1	98%
T10741	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
T14136	AG-024322	837364-57-5	98%
T14136	AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
T10743	CDK9-IN-11	2748368-15-0	98%
T10743	CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
TN3247	7-O-Prenylscopoletin	13544-37-1	98%
TN3247	7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
T14990	CDK12-IN-3	2220184-50-7	98%
T14990	CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay).