T10546 |
Bio-THZ1
|
1604811-14-4
|
98%
|
|
bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).
|
T13153 |
THZ1-R
|
1621523-07-6
|
98%
|
|
THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).
|
T12355 |
Palbociclib-d8
|
1628752-83-9
|
98%
|
|
Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively)....
|
T10382 |
AS2863619 free base
|
2241300-50-3
|
98%
|
|
AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 ...
|
T13202L |
Trilaciclib
|
1374743-00-6
|
98%
|
|
Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
|
TL0017 |
Aristolactam AIIIa
|
97399-91-2
|
98%
|
|
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
|
T10464 |
Atuveciclib
|
2923012-24-0
|
98%
|
|
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].
|
TN1728 |
Hellebrigenin
|
465-90-7
|
98%
|
|
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. H...
|
T15731 |
Ribociclib succinate hydrate
|
1374639-79-8
|
98%
|
|
Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyc...
|
TN3673 |
Clausine Z
|
866111-14-0
|
98%
|
|
Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
|
T11655 |
Indomethacin-D4
|
87377-08-0
|
98%
|
|
Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for huma...
|
T10465 |
Atuveciclib S-Enantiomer
|
2250279-81-1
|
98%
|
|
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, whic...
|
T10836 |
CLK1-IN-1
|
2123491-32-5
|
98%
|
|
CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
|
T14915 |
CDK12-IN-E9
|
2020052-55-3
|
98%
|
|
CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak bind...
|
T10096 |
(2S,3R)-Voruciclib
|
1253731-24-6
|
98%
|
|
(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.
|
T13696 |
FN-1501-propionic acid
|
2408642-48-6
|
98%
|
|
FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
|
T22440 |
TP-353
|
1253799-29-9
|
99.98%
|
|
TP-353 (EOS-61973) is a CDK7 inhibitor.
|
T11960 |
MBM-55
|
2083622-09-5
|
99.98%
|
|
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
|
T6162 |
BS-181 hydrochloride
|
1397219-81-6
|
99.97%
|
|
BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9...
|
T3186 |
NU2058
|
161058-83-9
|
99.95%
|
|
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
|