T8484 |
JSH-150
|
2247481-21-4
|
99.96%
|
|
JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).
|
T3186 |
NU2058
|
161058-83-9
|
99.95%
|
|
NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
|
T3700 |
SCH900776 (S-isomer)
|
891494-64-7
|
99.95%
|
|
SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2...
|
T14914 |
Cdk1/2 Inhibitor III
|
443798-55-8
|
99.94%
|
|
Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.
|
T6167 |
SU9516
|
377090-84-1
|
99.94%
|
|
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
|
T6940 |
PHA-767491 hydrochloride
|
942425-68-5
|
99.92%
|
|
PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against...
|
T8819 |
SU-9516
|
666837-93-0
|
99.91%
|
|
SU9516 is a selectively potent ATP-competitive inhibitor of CDKs.
|
T1917 |
GSK 3 Inhibitor IX
|
667463-62-9
|
99.9%
|
|
GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity w...
|
T10096L |
Voruciclib
|
1000023-04-0
|
99.89%
|
|
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse larg...
|
T1778 |
AT7519 Hydrochloride
|
902135-91-5
|
99.88%
|
|
AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
|
T2118 |
SC-514
|
354812-17-2
|
99.88%
|
|
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
|
T2615 |
Flavopiridol hydrochloride
|
131740-09-5
|
99.88%
|
|
Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib ...
|
T2381 |
Abemaciclib
|
1231929-97-7
|
99.87%
|
|
Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat ad...
|
T2440 |
IC261
|
186611-52-9
|
99.86%
|
|
IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
|
T3971 |
CASIN
|
425399-05-9
|
99.86%
|
|
CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
|
T6612 |
NU6027
|
220036-08-8
|
99.85%
|
|
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
|
T6199 |
Ribociclib
|
1211441-98-3
|
99.85%
|
|
Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50:10/39 nM).
|
T6240 |
Palbociclib Isethionate
|
827022-33-3
|
99.85%
|
|
Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional...
|
T6837 |
Flavopiridol
|
146426-40-6
|
99.85%
|
|
Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective fo...
|
T79404 |
A09-003
|
2911646-14-3
|
99.84%
|
|
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the ...
|