CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T3352	XL413	1169558-38-6	99.38%
T3352	XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the a...
TQ0068	NVP-LCQ195	902156-99-4	99.36%
TQ0068	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
T6924	Riviciclib hydrochloride	920113-03-7	99.36%
T6924	Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.
T2028	NG 52	212779-48-1	99.36%
T2028	NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.
T8463	PF-06873600	2185857-97-8	99.36%
T8463	PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respectiv...
T1837	BX-912	702674-56-4	99.34%
T1837	BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
T36038	SY-5609	2417302-07-7	99.34%
T36038	SY-5609 is a selective and noncovalent inhibitor of CDK7(KD = 0.065 nM) with antitumor activity and inhibits apoptosis.
TQ0266	MSC2530818	1883423-59-3	99.33%
TQ0266	MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM).
T9446	KB-0742 dihydrochloride	2416874-75-2	99.32%
T9446	KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.
T27423	GNE-375	1926989-06-1	99.32%
T27423	GNE-375 is a selective and potent BRD9 inhibitor (IC50: 5 nM).GNE-375 inhibits BRD4, TAF1, and CECR2, and can be used to study epigenetic resistance.
T6057	URMC-099	1229582-33-5	99.32%
T6057	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T6866	AUZ 454	853299-07-7	99.3%
T6866	AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respec...
T10738	Abemaciclib metabolite M20	2138499-06-4	99.29%
T10738	Abemaciclib metabolite M20 (CDK4/6-IN-4) is an active metabolite of Abemaciclib. Abemaciclib metabolite M20 is a selective CDK4/6 inhibitor and can be used for r...
T16324	Nimbolide	25990-37-8	99.28%
T16324	Nimbolide suppresses CDK4/CDK6 kinase activity. Nimbolide inhibits the NF-κB, Wnt, PI3K-Akt, MAPK, and JAK-STAT signaling pathways. Nimbolide causes apoptosis th...
T21314	Amsilarotene	125973-56-0	99.27%
T21314	Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors ...
T10735	CDK4/6/1 Inhibitor	2099128-41-1	99.26%
T10735	CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some type...
T10729	Cdc7-IN-7	1402059-17-9	99.25%
T10729	Cdc7-IN-7 is a potent inhibitor of Cdc7 kinase.
T8866	GW779439X	551919-98-3	99.23%
T8866	GW779439X is an inhibitor of CDK.
T2506	AZD-5438	602306-29-6	99.23%
T2506	AZD-5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM), CDK2(IC50=6 nM), CDK9(IC50=20 nM).
T6139	A-674563	552325-73-2	99.21%
T6139	A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.