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Membrane transporter/Ion channel CGRP Receptor

CGRP Receptor

CGRP receptor is found in myelinated A-fibers axon which is required for ligand specificity and function of the receptor. The CGRP receptor has three subunits: receptor activity-modifying protein 1 (RAMP1), calcitonin-like receptor (CLR) and receptor component protein (RCP).[17] The complex central receptor is the G protein-coupled receptor calcitonin receptor-like receptor (CALCRL) which is necessary for CGRP and adrenomedullin (AM receptors). For function CGRP, CALCRL must coincide with RAMP1 where the ligand-binding domain of CGRP is located.
Cat No. product name
T4610 BMS-927711 BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
T13480 (S)-(-)-5-Fluorowillardiine (S)-(-)-5-Fluorowillardiine is a potent and specific agonist of AMPAR.
T16107 ML230 ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respective...
TP1040 Calcitonin salmon Calcitonin salmon, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.
BMS-927711
T4610CAS 1289023-67-1
BMS-927711 is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
(S)-(-)-5-Fluorowillardiine
T13480CAS 140187-23-1
(S)-(-)-5-Fluorowillardiine is a potent and specific agonist of AMPAR.
ML230
T16107CAS 1776055-05-0
ML230 is a selective ATP-binding cassette (ABC) transporter ABCG2 inhibitor. It 36-fold selective for ABCG2 over ABCB1 (EC50s: 0.13 μM and 4.65 μM, respective...
Calcitonin salmon
TP1040CAS 47931-85-1
Calcitonin salmon, a calcium regulating hormone, is used to treat osteoporosis in women who are at least 5 years past menopause.