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COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0890 Mefenamic acid 61-68-7 99.85%
Mefenamic acid
Mefenamic acid (CN-35355) is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cycloox...
T3S0509 Gaultherin 490-67-5 99.85%
Gaultherin
Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, no...
T9284 Dexketoprofen trometamol 156604-79-4 99.85%
Dexketoprofen trometamol
Dexketoprofen trometamol is a modified non-selective COX inhibitor with a rapid onset of action that is available as both oral and parenteral formulations.
T5727 CAFESTOL 469-83-0 99.84%
CAFESTOL
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
T7882 Indomethacin farnesil 85801-02-1 99.84%
Indomethacin farnesil
Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (...
T1002 Etodolac 41340-25-4 99.84%
Etodolac
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pai...
T2553 Etofenamate 30544-47-9 99.83%
Etofenamate
Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
T6465 Dexamethasone Sodium Phosphate 55203-24-2 99.83%
Dexamethasone Sodium Phosphate
Dexamethasone Sodium Phosphate (Dexadreson) , an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent gluc...
T1301 Guaiacol 90-05-1 99.83%
Guaiacol
Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic...
T1427 2-(Phosphonooxy)benzoic acid 6064-83-1 99.83%
2-(Phosphonooxy)benzoic acid
2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.
T3S0645 N-trans-Feruloyltyramine 66648-43-9 99.81%
N-trans-Feruloyltyramine
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NT...
T3877 Esculentoside A 65497-07-6 99.81%
Esculentoside A
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
T7030 Anemarsaponin B 139051-27-7 99.81%
anemarsaponin B
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
T0432 Diclofenac diethylamine 78213-16-8 99.81%
Diclofenac diethylamine
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
T23333 SC-58125 162054-19-5 99.81%
SC-58125
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can i...
T5010 Propyphenazone 479-92-5 99.81%
Propyphenazone
Propyphenazone (4-Isopropylantipyrine), a pyrazolone derivative, exhibits anti-inflammatory, analgesic, and antipyretic properties and acts as a precursor for pr...
T0693 Niflumic acid 4394-00-7 99.79%
Niflumic acid
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
T3747 Syringaldehyde 134-96-3 99.79%
syringaldehyde
syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia offici...
TN2232 Soyasaponin Ab 118194-13-1 99.79%
Soyasaponin Ab
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
T9472 Rebamipide mofetil 1527495-76-6 99.78%
Rebamipide mofetil
Rebamipide mofetil is an orally active prodrug of Rebamipide which is a mucoprotective agent.
Mefenamic acid
T0890
Mefenamic acid (CN-35355) is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cycloox...
Gaultherin
T3S0509
Gaultherin has analgesic, and anti-inflammatory activities.Gaultherin lacks gastric ulcerogenic effect, because of it released salicylate in intestine slowly, no...
Dexketoprofen trometamol
T9284
Dexketoprofen trometamol is a modified non-selective COX inhibitor with a rapid onset of action that is available as both oral and parenteral formulations.
CAFESTOL
T5727
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
Indomethacin farnesil
T7882
Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug (...
Etodolac
T1002
Etodolac (AY-24236) inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin which is involved in the induction of pai...
Etofenamate
T2553
Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.
Dexamethasone Sodium Phosphate
T6465
Dexamethasone Sodium Phosphate (Dexadreson) , an interleukin receptor modulator, has anti-inflammatory and immunosuppressant effects. It belongs to a potent gluc...
Guaiacol
T1301
Guaiacol (2-Methoxyphenol) is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic...
2-(Phosphonooxy)benzoic acid
T1427
2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.
N-trans-Feruloyltyramine
T3S0645
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NT...
Esculentoside A
T3877
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. E...
anemarsaponin B
T7030
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
Diclofenac diethylamine
T0432
Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).
SC-58125
T23333
SC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor, with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo, and it also can i...
Propyphenazone
T5010
Propyphenazone (4-Isopropylantipyrine), a pyrazolone derivative, exhibits anti-inflammatory, analgesic, and antipyretic properties and acts as a precursor for pr...
Niflumic acid
T0693
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
syringaldehyde
T3747
syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia offici...
Soyasaponin Ab
TN2232
Soyasaponin Ab may represent a viable candidate for effective vaccine adjuvant, TLR4 receptor dependent pathway may be involved in immune stimulatory effects of ...
Rebamipide mofetil
T9472
Rebamipide mofetil is an orally active prodrug of Rebamipide which is a mucoprotective agent.
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TargetMol