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Search Results for " csf-1r "

Targets

37

Compounds

16

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T10894 CSF1R-IN-1 c-Fms
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.
T13194 CSF1R-IN-2 c-Fms , c-Met/HGFR , Src
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
T5586 CFMS Receptor Inhibitor II c-Fms
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor
T14380 AZD7507 CSF-1R , HER , Sodium Channel
AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.
T6119 Sotuletinib BLZ945 c-Fms , CSF-1R
Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs.
TQ0015 PRN1371 c-Fms , FGFR , CSF-1R
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T10652 Vimseltinib DCC-3014 c-Fms , CSF-1R , c-Kit
Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).
T7100 PLX5622 PLX-5622 c-Fms , CSF-1R
PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
T2115 Pexidartinib PLX-3397 Apoptosis , c-Fms , FLT , CSF-1R , c-Kit
Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
T2659 GW2580 GW 2580,SC-203877 c-Fms
GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.
T2624 OSI-930 OSI 930 Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit
OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors.
T15199 Edicotinib JNJ-527,JNJ-40346527 c-Fms , FLT , CSF-1R , c-Kit
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the pote...
T35570 Chiauranib CS2164 c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...
T4315 Ki20227 c-Fms , VEGFR , CSF-1R , PDGFR , c-Kit
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451/217 nM), respectively.
T6930 Pazopanib Hydrochloride GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala c-Fms , VEGFR , FGFR , PDGFR , c-Kit , Autophagy
Pazopanib Hydrochloride (Votrient HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, resp...
T2514 Linifanib ABT-869,RG3635,AL-39324 Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T6289 Dovitinib TKI258,CHIR-258 VEGFR , FGFR , FLT , PDGFR , c-Kit
Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E...
T6028 PF 477736 PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T1925 PLX647 c-Fms , c-Kit
PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).
T35333 ARRY-382 CSF-1R
ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.
T76776 Emactuzumab RO 5509554,RG 7155 c-Fms , TAM Receptor
Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa...
T1667 Tandutinib MLN518,CT53518,NSC726292 Apoptosis , FLT , CSF-1R , PDGFR , Src , c-Kit
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu...
T64066 CSF1R-IN-3 c-Fms , CSF-1R
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef...
T2500 Cediranib AZD2171,NSC-732208 VEGFR , FLT , PDGFR , c-Kit , Autophagy
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...
T62313 CSF1R-IN-10
CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).
T62390 CSF1R-IN-8
CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).
T62318 CSF1R-IN-9
CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).
T11390 GENZ-882706 RA03546849 CSF-1R
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
T10647 C-Fms-IN-8 CSF-1R
c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.
T10644 C-Fms-IN-10 Others
c-Fms-IN-10 is the derivative of thieno [3,2-d] pyrimidine, a kinase inhibitor of FMS (Colony-stimulating factor-1 receptor, CSF-1R; IC50: 2 nM) with anti-tumor activity.
T76868 Lacnotuzumab
Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis [...
T62190 CSF1R-IN-7
CSF1R-IN-7 (Formula I) is a CSF-1R inhibitor that can be used to study Alzheimer's disease.
T62342 CSF1R-IN-4
CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40.
T62187 CSF1R-IN-6
CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF1R-IN-6 is a potent inhibitor of CSF1R, which is expressed in macrophages and is dependent on the CSF-1/CSF-1R signalling pathway for survival and differentiation of macropha...
T76915 Axatilimab
Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R . Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases [1] [2] .
T11729 JTE-952 Histamine Receptor
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , resp...
T62364 CSF1R-IN-5
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases.

Compounds

CSF1R-IN-1
T10894
Synonym:
Target: c-Fms
CSF1R-IN-2
T13194
Synonym:
Target: c-Fms, c-Met/HGFR, Src
cFMS Receptor Inhibitor II
T5586
Synonym:
Target: c-Fms
AZD7507
T14380
Synonym:
Target: CSF-1R, HER, Sodium Channel
Sotuletinib
T6119
Synonym: BLZ945
Target: c-Fms, CSF-1R
PRN1371
TQ0015
Synonym:
Target: c-Fms, FGFR, CSF-1R
Vimseltinib
T10652
Synonym: DCC-3014
Target: c-Fms, CSF-1R, c-Kit
PLX5622
T7100
Synonym: PLX-5622
Target: c-Fms, CSF-1R
Pexidartinib
T2115
Synonym: PLX-3397
Target: Apoptosis, c-Fms, FLT, CSF-1R, c-Kit
GW2580
T2659
Synonym: GW 2580,SC-203877
Target: c-Fms
OSI-930
T2624
Synonym: OSI 930
Target: Apoptosis, c-Fms, Raf, VEGFR, FLT, CSF-1R, Src, c-Kit
Edicotinib
T15199
Synonym: JNJ-527,JNJ-40346527
Target: c-Fms, FLT, CSF-1R, c-Kit
Chiauranib
T35570
Synonym: CS2164
Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase
Ki20227
T4315
Synonym:
Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit
Pazopanib Hydrochloride
T6930
Synonym: GW786034,Pazopanib HCl,GW786034 HCl,Votrient HCl,Armala
Target: c-Fms, VEGFR, FGFR, PDGFR, c-Kit, Autophagy
Linifanib
T2514
Synonym: ABT-869,RG3635,AL-39324
Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy
Dovitinib
T6289
Synonym: TKI258,CHIR-258
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
PF 477736
T6028
Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736
Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase
PLX647
T1925
Synonym:
Target: c-Fms, c-Kit
ARRY-382
T35333
Synonym:
Target: CSF-1R
Emactuzumab
T76776
Synonym: RO 5509554,RG 7155
Target: c-Fms, TAM Receptor
Tandutinib
T1667
Synonym: MLN518,CT53518,NSC726292
Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit
CSF1R-IN-3
T64066
Synonym:
Target: c-Fms, CSF-1R
Cediranib
T2500
Synonym: AZD2171,NSC-732208
Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy
CSF1R-IN-10
T62313
Synonym:
Target:
CSF1R-IN-8
T62390
Synonym:
Target:
CSF1R-IN-9
T62318
Synonym:
Target:
GENZ-882706
T11390
Synonym: RA03546849
Target: CSF-1R
c-Fms-IN-8
T10647
Synonym:
Target: CSF-1R
c-Fms-IN-10
T10644
Synonym:
Target: Others
Lacnotuzumab
T76868
Synonym:
Target:
CSF1R-IN-7
T62190
Synonym:
Target:
CSF1R-IN-4
T62342
Synonym:
Target:
CSF1R-IN-6
T62187
Synonym:
Target:
Axatilimab
T76915
Synonym:
Target:
JTE-952
T11729
Synonym:
Target: Histamine Receptor
CSF1R-IN-5
T62364
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-01037 CSF1R Protein (Met1-Glu512), Human, Recombinant (His) Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPJ-01419 CSF1R Protein, Cynomolgus, Recombinant (His) Cynomolgus Human Cells
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPJ-01418 CSF1R Protein, Cynomolgus, Recombinant (hFc) Cynomolgus Human Cells
Macrophage colony-stimulating factor 1 receptor (CSF1R) is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-l...
TMPY-04938 CSF1R Protein, Mouse, Recombinant (His), Biotinylated Mouse HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-05436 CSF1R Protein, Mouse, Recombinant (hFc) Mouse HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-01833 CSF1R Protein, Mouse, Recombinant (His) Mouse HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-00881 CSF1R Protein, Human, Recombinant Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-05429 CSF1R Protein, Human, Recombinant (hFc) Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-05045 CSF1R Protein, Human, Recombinant (Domain I&II&III, His) Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-06389 CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-05264 CSF1R Protein, Human, Recombinant (mFc) Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-06384 CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-04358 CSF1R Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-05513 CSF1R Protein (Ala299-Glu512), Human, Recombinant (His) Human HEK293
M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein...
TMPY-05296 IL-34 Protein, Human, Recombinant (His) Human CHO
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt...
TMPY-00986 IL-34 Protein, Mouse, Recombinant (His) Mouse HEK293
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt...
CSF1R Protein (Met1-Glu512), Human, Recombinant (His)
TMPY-01037
Species: Human
Expression System: HEK293
CSF1R Protein, Cynomolgus, Recombinant (His)
TMPJ-01419
Species: Cynomolgus
Expression System: Human Cells
CSF1R Protein, Cynomolgus, Recombinant (hFc)
TMPJ-01418
Species: Cynomolgus
Expression System: Human Cells
CSF1R Protein, Mouse, Recombinant (His), Biotinylated
TMPY-04938
Species: Mouse
Expression System: HEK293
CSF1R Protein, Mouse, Recombinant (hFc)
TMPY-05436
Species: Mouse
Expression System: HEK293
CSF1R Protein, Mouse, Recombinant (His)
TMPY-01833
Species: Mouse
Expression System: HEK293
CSF1R Protein, Human, Recombinant
TMPY-00881
Species: Human
Expression System: HEK293
CSF1R Protein, Human, Recombinant (hFc)
TMPY-05429
Species: Human
Expression System: HEK293
CSF1R Protein, Human, Recombinant (Domain I&II&III, His)
TMPY-05045
Species: Human
Expression System: HEK293
CSF1R Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPY-06389
Species: Human
Expression System: HEK293
CSF1R Protein, Human, Recombinant (mFc)
TMPY-05264
Species: Human
Expression System: HEK293
CSF1R Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06384
Species: Human
Expression System: HEK293
CSF1R Protein, Human, Recombinant (His & GST)
TMPY-04358
Species: Human
Expression System: Baculovirus-Insect Cells
CSF1R Protein (Ala299-Glu512), Human, Recombinant (His)
TMPY-05513
Species: Human
Expression System: HEK293
IL-34 Protein, Human, Recombinant (His)
TMPY-05296
Species: Human
Expression System: CHO
IL-34 Protein, Mouse, Recombinant (His)
TMPY-00986
Species: Mouse
Expression System: HEK293
TargetMol